Tailoring the Foreign Body Response for In Situ Vascular Tissue Engineering

2015 ◽  
Vol 21 (5) ◽  
pp. 436-446 ◽  
Author(s):  
Tonia C. Rothuizen ◽  
Febriyani F.R. Damanik ◽  
James M. Anderson ◽  
Tom Lavrijsen ◽  
Martijn A.J. Cox ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Foreign Body ◽  
Vascular Tissue ◽  
Foreign Body Response ◽  
Vascular Tissue Engineering ◽  
Body Response

scholarly journals Immunobiology and Application of Aloe vera-Based Scaffolds in Tissue Engineering

2021 ◽  
Vol 22 (4) ◽  
pp. 1708
Author(s):  
Saeedeh Darzi ◽  
Kallyanashis Paul ◽  
Shanilka Leitan ◽  
Jerome A. Werkmeister ◽  
Shayanti Mukherjee
Keyword(s):  
Tissue Engineering ◽  
Foreign Body ◽  
Scientific Evidence ◽  
Aloe Vera ◽  
Material Design ◽  
Foreign Body Response ◽  
The Body ◽  
Design Strategies ◽  
Immunomodulatory Effects ◽  
Body Response

Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.

scholarly journals Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering

2017 ◽  
Vol 9 (3) ◽  
pp. 035007 ◽  
Author(s):  
Jeffrey J D Henry ◽  
Jian Yu ◽  
Aijun Wang ◽  
Randall Lee ◽  
Jun Fang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Biological Properties ◽  
Vascular Tissue Engineering

Preparation of Electrospun Poly(ε-caprolactone)/Poly(trimethylene carbonate) Blend Scaffold for In Situ Vascular Tissue Engineering

2012 ◽  
Vol 629 ◽  
pp. 60-63
Author(s):  
Tao Jiang ◽  
Guo Quan Zhang ◽  
Hui Li ◽  
Ji Na Xun
Keyword(s):  
Tissue Engineering ◽  
Vascular Graft ◽  
Vascular Tissue ◽  
Electrospinning Process ◽  
Vascular Tissue Engineering ◽  
Trimethylene Carbonate ◽  
Scaffold Materials ◽  
Degradation Time

In the active field of vascular graft research, in situ vascular tissue engineering is a novel concept. This approach aims to use biodegradable synthetic materials. After implantation, the synthetic material progressively degrades and should be replaced by autologous cells. Poly (ε-caprolactone) (PCL) is often used for vascular graft because of its good mechanical strength and its biocompatibility. It is easily processed into micro and nano-fibers by electrospinning to form a porous, cell-friendly scaffold. However, the degradation time of polycaprolactone is too long to match the tissue regeneration time. In this study, poly (ε-caprolactone) /poly (trimethylene carbonate) (PTMC) blend scaffold materials have been prepared for biodegradable vascular graft using an electrospinning process. Because the degradation time of PTMC is shorter than PCL in vivo. The morphological characters of PCL/PTMC blend scaffold materials were investigated by scanning electron microscope (SEM). The molecular components and some physical characteristics of the blend scaffold materials were tested by FT-IR and DSC analysis.

Hydrogel Complex Electrospun Scaffolds and Their Multiple Functions in In Situ Vascular Tissue Engineering

2021 ◽  
Vol 4 (3) ◽  
pp. 2373-2384
Author(s):  
Xue Geng ◽  
Ze-Qin Xu ◽  
Cheng-Zhao Tu ◽  
Jia Peng ◽  
Xin Jin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Multiple Functions ◽  
Electrospun Scaffolds

Foreign Body Response Investigated With an Implanted Biosensor by In Situ Electrical Impedance Spectroscopy

2008 ◽  
Vol 8 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Floyd B. Karp ◽  
Neil A. Bernotski ◽  
Thelma I. Valdes ◽  
Karl F. Bohringer ◽  
Buddy D. Ratner
Keyword(s):  
Foreign Body ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Foreign Body Response ◽  
Electrical Impedance Spectroscopy ◽  
Body Response

Polymer-based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

2012 ◽  
Vol 12 (5) ◽  
pp. 577-590 ◽  
Author(s):  
Emanuela S. Fioretta ◽  
Joost O. Fledderus ◽  
Ewelina A. Burakowska-Meise ◽  
Frank P. T. Baaijens ◽  
Marianne C. Verhaar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Endothelial Colony Forming Cells

scholarly journals Hemodynamic loads distinctively impact the secretory profile of biomaterial-activated macrophages – implications for in situ vascular tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 132-147 ◽  
Author(s):  
Tamar B. Wissing ◽  
Eline E. van Haaften ◽  
Suzanne E. Koch ◽  
Bastiaan D. Ippel ◽  
Nicholas A. Kurniawan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Activated Macrophages ◽  
Scaffold Degradation

Macrophages play a governing role in material-driven tissue regeneration. Here we show that the paracrine signals of macrophages to direct tissue regeneration and scaffold degradation are dependent on hemodynamic loads.

Vascular tissue engineering: Biomechanical studies on autologeous small-calibred vessels

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
K Kallenbach ◽  
J Heine ◽  
E Lefik ◽  
S Cebotari ◽  
A Lichtenberg ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering
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