Polymer-based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

2012 ◽  
Vol 12 (5) ◽  
pp. 577-590 ◽  
Author(s):  
Emanuela S. Fioretta ◽  
Joost O. Fledderus ◽  
Ewelina A. Burakowska-Meise ◽  
Frank P. T. Baaijens ◽  
Marianne C. Verhaar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Endothelial Colony Forming Cells

scholarly journals Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering

2017 ◽  
Vol 9 (3) ◽  
pp. 035007 ◽  
Author(s):  
Jeffrey J D Henry ◽  
Jian Yu ◽  
Aijun Wang ◽  
Randall Lee ◽  
Jun Fang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Biological Properties ◽  
Vascular Tissue Engineering

Preparation of Electrospun Poly(ε-caprolactone)/Poly(trimethylene carbonate) Blend Scaffold for In Situ Vascular Tissue Engineering

2012 ◽  
Vol 629 ◽  
pp. 60-63
Author(s):  
Tao Jiang ◽  
Guo Quan Zhang ◽  
Hui Li ◽  
Ji Na Xun
Keyword(s):  
Tissue Engineering ◽  
Vascular Graft ◽  
Vascular Tissue ◽  
Electrospinning Process ◽  
Vascular Tissue Engineering ◽  
Trimethylene Carbonate ◽  
Scaffold Materials ◽  
Degradation Time

In the active field of vascular graft research, in situ vascular tissue engineering is a novel concept. This approach aims to use biodegradable synthetic materials. After implantation, the synthetic material progressively degrades and should be replaced by autologous cells. Poly (ε-caprolactone) (PCL) is often used for vascular graft because of its good mechanical strength and its biocompatibility. It is easily processed into micro and nano-fibers by electrospinning to form a porous, cell-friendly scaffold. However, the degradation time of polycaprolactone is too long to match the tissue regeneration time. In this study, poly (ε-caprolactone) /poly (trimethylene carbonate) (PTMC) blend scaffold materials have been prepared for biodegradable vascular graft using an electrospinning process. Because the degradation time of PTMC is shorter than PCL in vivo. The morphological characters of PCL/PTMC blend scaffold materials were investigated by scanning electron microscope (SEM). The molecular components and some physical characteristics of the blend scaffold materials were tested by FT-IR and DSC analysis.

Hydrogel Complex Electrospun Scaffolds and Their Multiple Functions in In Situ Vascular Tissue Engineering

2021 ◽  
Vol 4 (3) ◽  
pp. 2373-2384
Author(s):  
Xue Geng ◽  
Ze-Qin Xu ◽  
Cheng-Zhao Tu ◽  
Jia Peng ◽  
Xin Jin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Multiple Functions ◽  
Electrospun Scaffolds

Tailoring the Foreign Body Response for In Situ Vascular Tissue Engineering

2015 ◽  
Vol 21 (5) ◽  
pp. 436-446 ◽  
Author(s):  
Tonia C. Rothuizen ◽  
Febriyani F.R. Damanik ◽  
James M. Anderson ◽  
Tom Lavrijsen ◽  
Martijn A.J. Cox ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Foreign Body ◽  
Vascular Tissue ◽  
Foreign Body Response ◽  
Vascular Tissue Engineering ◽  
Body Response

scholarly journals Hemodynamic loads distinctively impact the secretory profile of biomaterial-activated macrophages – implications for in situ vascular tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 132-147 ◽  
Author(s):  
Tamar B. Wissing ◽  
Eline E. van Haaften ◽  
Suzanne E. Koch ◽  
Bastiaan D. Ippel ◽  
Nicholas A. Kurniawan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Activated Macrophages ◽  
Scaffold Degradation

Macrophages play a governing role in material-driven tissue regeneration. Here we show that the paracrine signals of macrophages to direct tissue regeneration and scaffold degradation are dependent on hemodynamic loads.

Vascular tissue engineering: Biomechanical studies on autologeous small-calibred vessels

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
K Kallenbach ◽  
J Heine ◽  
E Lefik ◽  
S Cebotari ◽  
A Lichtenberg ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering

Surface Modification by Nanobiomaterials for Vascular Tissue Engineering Applications

2020 ◽  
Vol 27 (10) ◽  
pp. 1634-1646 ◽  
Author(s):  
Huey-Shan Hung ◽  
Shan-hui Hsu
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Great Success ◽  
Natural Polymers ◽  
Vascular Biomaterials

Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.

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