scholarly journals Enhanced Mandibular Bone Repair by Combined Treatment of Bone Morphogenetic Protein 2 and Small-Molecule Phenamil

2017 ◽  
Vol 23 (5-6) ◽  
pp. 195-207 ◽  
Author(s):  
Jiabing Fan ◽  
Mian Guo ◽  
Choong Sung Im ◽  
Joan Pi-Anfruns ◽  
Zhong-Kai Cui ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Bone Repair ◽  
Combined Treatment ◽  
Bone Morphogenetic Protein 2 ◽  
Mandibular Bone ◽  
Morphogenetic Protein

scholarly journals Acceleration of bone union by in situ-formed hydrogel containing bone morphogenetic protein-2 in a mouse refractory fracture model

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Shintaro Shoji ◽  
Kentaro Uchida ◽  
Wataru Satio ◽  
Hiroyuki Sekiguchi ◽  
Gen Inoue ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Repair ◽  
Fracture Site ◽  
Bone Union ◽  
Fracture Model ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
And Control ◽  
Gene Expression Levels

Abstract Background An enzymatic crosslinking strategy using hydrogen peroxide and horseradish peroxidase is receiving increasing attention for application with in situ-formed hydrogels (IFHs). Several studies have reported the application of IFHs in cell delivery and tissue engineering. IFHs may also be ideal carrier materials for bone repair, although their potential as a carrier for bone morphogenetic protein (BMP)-2 has yet to be examined. Here, we examined the effect of an IFH made of hyaluronic acid (IFH-HA) containing BMP-2 in promoting osteogenesis in a mouse refractory fracture model. Methods Immediately following a fracture procedure, animals either received no treatment (control) or an injection of IFH-HA/PBS or IFH-HA containing 2 μg BMP-2 (IFH-HA/BMP-2) into the fracture site (n = 16, each treatment). Results Fracture sites injected with IFH-HA/BMP-2 showed significantly greater bone volume, bone mineral content, and bone union compared with sites receiving no treatment or treated with IFH-HA/PBS alone (each n = 10). Gene expression levels of osteogenic markers, Alpl, Bglap, and Osx, were significantly raised in the IFH-HA/BMP-2 group compared to the IFH-HA/PBS and control groups (each n = 6). Conclusion IFH-HA/BMP-2 may contribute to the treatment of refractory fractures.

scholarly journals A Comparative Genomic and Transcriptional Survey Providing Novel Insights into Bone Morphogenetic Protein 2 (bmp2) in Fishes

2019 ◽  
Vol 20 (24) ◽  
pp. 6137 ◽  
Author(s):  
Guang Yang ◽  
Zhendong Qin ◽  
Hongyan Kou ◽  
Rishen Liang ◽  
Lijuan Zhao ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Repair ◽  
Fish Bone ◽  
Transcriptomic Analysis ◽  
Bone Morphogenetic Protein 2 ◽  
Comparative Genomic ◽  
Sequence Alignments ◽  
Cell Proliferation And Differentiation ◽  
Morphogenetic Protein

Intermuscular bones (IBs) are only found in the muscles of fish. Bone morphogenetic protein 2 (bmp2) is considered to be the most active single osteogenesis factor. It promotes cell proliferation and differentiation during bone repair, as well as inducing the formation of bones and cartilages in vivo. However, detailed investigations of this family in fish are incredibly limited. Here, we have used a variety of published and unpublished bmp2 sequences for teleosts and cartilage fish in order to explore and expand our understanding of bmp2 genes in fish. Our results confirmed that teleost genomes contain two or more bmp2 genes, and the diversity of bmp2 genes in vertebrates appears to be as a result of a combination of whole genome duplication (WGD) and gene loss. Differences were also observed in tissue distribution and relative transcription abundance of the bmp2s through a transcriptomic analysis. Our data also indicated that bmp2b may play an important role in the formation of IBs in teleosts. In addition, protein sequence alignments and 3D structural predictions of bmp2a and bmp2b supported their similar roles in fishes. To summarize, our existing work provided novel insights into the bmp2 family genes in fishes through a mixture of comparative genomic and transcriptomic analysis.

Effects of the combination of low-level laser irradiation and recombinant human bone morphogenetic protein-2 in bone repair

2011 ◽  
Vol 27 (5) ◽  
pp. 971-977 ◽  
Author(s):  
Anderson Paim Rosa ◽  
Luiz Gustavo de Sousa ◽  
Simone Cecilio Hallak Regalo ◽  
João Paulo Mardegan Issa ◽  
Ana Paula Amorim Barbosa ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Laser Irradiation ◽  
Bone Repair ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Level Laser ◽  
Human Bone Morphogenetic Protein ◽  
Low Level Laser Irradiation ◽  
Recombinant Human Bone

scholarly journals Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jiabing Fan ◽  
Joan Pi-Anfruns ◽  
Mian Guo ◽  
Dan C. S. Im ◽  
Zhong-Kai Cui ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein
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