Antibacterial Effect of Copper Sulfide Nanoparticles on Infected Wound Healing

2021 ◽  
Author(s):  
Yuan Liang ◽  
Jiale Zhang ◽  
Huahong Quan ◽  
Pei Zhang ◽  
Keteng Xu ◽  
...  
2022 ◽  
pp. 131690
Author(s):  
Xueyun Gong ◽  
Mi Chen ◽  
Bo Lei ◽  
Weidong Xia ◽  
Xingxing Zhang
Keyword(s):  

2022 ◽  
Author(s):  
Yan Li ◽  
Miao-miao Han ◽  
Yue Cai ◽  
Bing Jiang ◽  
Yuanxin Zhang ◽  
...  

The process of wound healing is often accompanied by bacterial infection, which is a serious threat to human health. The abuse of antibiotics in traditional therapy aggravates the resistance of...


Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1215
Author(s):  
Mykola Pernakov ◽  
Maria Laura Ermini ◽  
Oksana Sulaieva ◽  
Domenico Cassano ◽  
Marco Santucci ◽  
...  

Surgical site infection (SSI) substantially contributes each year to patients’ morbidity and mortality, accounting for about 15% of all nosocomial infections. SSI drastically increases the rehab stint and expenses while jeopardizing health outcomes. Besides prevention, the treatment regime relies on an adequate antibiotic therapy. On the other hand, resistant bacterial strains have currently reached up to 34.3% of the total infections, and this percentage grows annually, reducing the efficacy of the common treatment schemes. Thus, new antibacterial strategies are urgently demanded. Here, we demonstrated in rats the effectiveness of non-persistent silver nano-architectures (AgNAs) in infected wound healing together with their synergistic action in combination with chlorhexidine. Besides the in vivo efficacy evaluation, we performed analysis of the bacteriological profile of purulent wound, histological evaluations, and macrophages polarization quantifications to further validate our findings and elucidate the possible mechanisms of AgNAs action on wound healing. These findings open the way for the composition of robust multifunctional nanoplatforms for the translation of safe and efficient topical treatments of SSI.


2013 ◽  
Vol 1537 ◽  
Author(s):  
Priscilla V. Quintana-Ramírez ◽  
M. C. Arenas

ABSTRACTPoly(3-hexylthiophene)/Titania (P3HT/TiO2) heterojunction has been widely studied in the field of hybrid solar cells. Usually, organic dyes shift the neat TiO2 absorption edge toward the visible range improving the conversion efficiency or/and the TiO2 surface is modified with ligands in order to increase the electron transport. On the other hand, copper sulfide, non-toxic semiconductor, has been included in bulk organic P3HT based solar cell, increasing the photocurrent density of devices. Therefore, we propose the use of copper sulfide in the hybrid TiO2/P3HT heterojunction to determine its effect in the performance of TiO2/P3HT solar cell. Copper sulfide nanocrystals (CuxS) were synthesized at 230 °C, 240 °C and 260 °C and, they were mixed with P3HT in order to form P3HT:CuxS bulk heterojunctions. Scattered grains and irregular morphology in the final topography of the reference device (P3HT/TiO2 heterojunction) were observed by AFM, while a granular morphology and a few pores like craters were observed in the devices containing P3HT:CuxS bulk heterojunctions. Chalcocite phase (Cu2S) was obtained at 230 and 240°C and, digenite (Cu1.8S) phase at 260°C, both copper sulfide phases are very promising for solar cells. Despite this, poor rectifications in the devices were found in the current-voltage curves of the devices containing copper sulfide nanocrystals in contrast to the P3HT/TiO2 cell (device without nanocrystals), it could be due to the current leakage or recombination process in the copper sulfide/TiO2 interface. It suggests future work in order to improve the devices.


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