scholarly journals Combined Strategy for Post-Operative Patients with Central Nervous System Infections Caused by Extensively Drug-Resistant/Pan-Drug–Resistant Acinetobacter baumannii: A Retrospective Study

2020 ◽  
Vol 21 (10) ◽  
pp. 853-858
Author(s):  
Jian-bo Chang ◽  
Yihao Chen ◽  
He Wang ◽  
Xiaojun Ma ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Central Nervous System Infections ◽  
Extensively Drug Resistant ◽  
Combined Strategy

scholarly journals Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug-ResistantAcinetobacter baumanniiin Austria

2013 ◽  
Vol 24 (3) ◽  
pp. e88-e90 ◽  
Author(s):  
M Hoenigl ◽  
M Drescher ◽  
G Feierl ◽  
T Valentin ◽  
G Zarfel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nosocomial Infections ◽  
Antimicrobial Agents ◽  
Northern Italy ◽  
Drug Resistant ◽  
Central Nervous System Infections ◽  
Successful Management ◽  
Gram Negative ◽  
Extensively Drug Resistant

Nosocomial infections caused by the Gram-negative coccobacillusAcinetobacter baumanniihave substantially increased over recent years. BecauseAcinetobacteris a genus with a tendency to quickly develop resistance to multiple antimicrobial agents, therapy is often complicated, requiring the return to previously used drugs. The authors report a case of meningitis due to extensively drug-resistantA baumanniiin an Austrian patient who had undergone neurosurgery in northern Italy. The case illustrates the limits of therapeutic options in central nervous system infections caused by extensively drug-resistant pathogens.

scholarly journals A combined strategy for postoperative patients with central nervous system infections caused by XDR/PDR Acinetobacter baumannii: a retrospective study

2019 ◽  
Author(s):  
Jianbo Chang ◽  
Yihao Chen ◽  
He Wang ◽  
Xiaojun Ma ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Antimicrobial Agents ◽  
Combined Therapy ◽  
Positive Culture ◽  
Central Nervous System Infections ◽  
Intractable Problems ◽  
The Individual ◽  
Combined Strategy

Abstract Background Postoperative central nervous system infections (PCNSIs) caused by extensively drug-resistant (XDR) or pandrug-resistant (PDR) Acinetobacter baumannii are rare but intractable problems. To investigate a potential combined strategy to treat AB organisms that are resistant to not only meropenem but also colistin. Methods We retrospectively reviewed cerebrospinal fluid positive culture isolates of AB in patients who underwent neurosurgery. Medical records were collected by standard forms and analyzed. Results 16 patients met the criteria and most patients were middle-aged men who had undergone craniotomy or endonasal transsphenoidal surgery. 68.8% AB isolates were XDR bacteria, and 18.8% isolates were PDR bacteria. 12 patients were treated by meropenem-based regimen strategy. Another 4 patients were administered tetracycline-based regimens. 93.8% patients were treated with therapeutic drainage, and strict hygiene rules were followed. Finally, 12 patients survived their infections, and the average Glasgow Outcome Scale score was 2.9±1.4 at discharge. And the mortality rates of carbapenem-resistant AB (CRAB) were 8.3%. Conclusions PCNSIs caused by XDR/PDR AB are a rare and serious complication. Combined therapy based on the individual situation, including appropriate antimicrobial agents, surgical management and strict hygiene management, might be an effective therapeutic strategy.

scholarly journals Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant Acinetobacter baumannii

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052092040 ◽  
Author(s):  
Liang-Ming Li ◽  
Wen-Jian Zheng ◽  
Shang-Wen Shi
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Adverse Reactions ◽  
Central Nervous System Infection ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Spinal Arachnoiditis ◽  
Safe Dose

In prior research, intrathecal tigecycline was successfully used to treat central nervous system infection by extensively drug-resistant Acinetobacter baumannii. However, little is known about its safe dose and adverse reactions. This study reports the case of a 28-year-old male patient who was diagnosed with central nervous system infection by extensively drug-resistant A. baumannii after the removal of a ventriculoperitoneal shunt. Intravenous and intrathecal tigecycline were administrated simultaneously. Spinal arachnoiditis was discovered after nine doses of intrathecal tigecycline. Spinal arachnoiditis was resolved after discontinuation of the antibiotic. This is the first report of an adverse reaction to intrathecal tigecycline. The case was complicated by spinal arachnoiditis, which obstructed the assessment of cerebrospinal fluid. The appropriate dose and administration schedule of intrathecal tigecycline remain to be determined.

Prevalence of human parechoviruses in central nervous system infections in children: A retrospective study in Shanghai, China

2012 ◽  
Vol 85 (2) ◽  
pp. 320-326 ◽  
Author(s):  
Huaqing Zhong ◽  
Yong Lin ◽  
Liyun Su ◽  
Lingfeng Cao ◽  
Menghua Xu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Central Nervous System Infections

Neurological Complications of Lymphomas and Leukemias

PEDIATRICS ◽  
1960 ◽  
Vol 25 (2) ◽  
pp. 303-303
Author(s):  
HENRY G. CRAMBLETT
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Multiple Myeloma ◽  
Nervous System ◽  
Retrospective Study ◽  
Cranial Nerves ◽  
Neurological Complications ◽  
Cord Compression ◽  
Central Nervous System Infections ◽  
Hospital Records

In a retrospective study, the authors have reviewed the hospital records of 5,778 patients with Hodgkin's disease, lymphosarcoma, multiple myeloma, and leukemia. A total of 795 neurobogic complications occurring in 745 patients were discovered which represented a patient incidence of approximately 13%. The complications which were encountered included spinal cord compression, infiltration of intracranial structures, compression and infiltration of peripheral and cranial nerves, intracranial hemorrhage, infiltration or invasion of the pituitary by tumor cells, and central nervous system infections occurring in association with the various malignancies.

scholarly journals Suboptimal management of central nervous system infections in children: a multi-centre retrospective study

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Christine Kelly ◽  
◽  
Aman Sohal ◽  
Benedict D Michael ◽  
Andrew Riordan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Central Nervous System Infections
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