Clinical Presentations and Outcomes of Post-Operative Central Nervous System Infection Caused by Multi-Drug–Resistant/Extensively Drug-Resistant Acinetobacter baumannii: A Retrospective Study

2019 ◽  
Vol 20 (6) ◽  
pp. 460-464
Author(s):  
Wen Liang ◽  
Zhu Yuan-Run ◽  
Yan Min
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Acinetobacter Baumannii ◽  
Central Nervous System Infection ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Clinical Presentations

scholarly journals Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant Acinetobacter baumannii

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052092040 ◽  
Author(s):  
Liang-Ming Li ◽  
Wen-Jian Zheng ◽  
Shang-Wen Shi
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Adverse Reactions ◽  
Central Nervous System Infection ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Spinal Arachnoiditis ◽  
Safe Dose

In prior research, intrathecal tigecycline was successfully used to treat central nervous system infection by extensively drug-resistant Acinetobacter baumannii. However, little is known about its safe dose and adverse reactions. This study reports the case of a 28-year-old male patient who was diagnosed with central nervous system infection by extensively drug-resistant A. baumannii after the removal of a ventriculoperitoneal shunt. Intravenous and intrathecal tigecycline were administrated simultaneously. Spinal arachnoiditis was discovered after nine doses of intrathecal tigecycline. Spinal arachnoiditis was resolved after discontinuation of the antibiotic. This is the first report of an adverse reaction to intrathecal tigecycline. The case was complicated by spinal arachnoiditis, which obstructed the assessment of cerebrospinal fluid. The appropriate dose and administration schedule of intrathecal tigecycline remain to be determined.

Cryptococcal infections in children: retrospective study and review from Australia

2019 ◽  
Vol 14 (18) ◽  
pp. 1531-1544
Author(s):  
Alice Grimshaw ◽  
Pamela Palasanthiran ◽  
Julie Huynh ◽  
Ben Marais ◽  
Sharon Chen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Acute Lymphoblastic Leukemia ◽  
Literature Review ◽  
Lymphoblastic Leukemia ◽  
Central Nervous System Infection ◽  
Significant Morbidity ◽  
Neurological Sequelae ◽  
Substantial Morbidity

Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identified via literature review: median age was 13.5 years (IQR 7.8–16 years), 18/22 (82%) had meningitis or central nervous system infection. Where outcome was reported, 11/18 (61%) died. Of six audit cases identified from 2008 to 2017, 5 (83%) had C. gattii disease and survived. One child with acute lymphoblastic leukemia and C. neoformans infection died. For survivors, persisting respiratory or neurological sequelae were reported in 4/6 cases (67%). Conclusion: Cryptococcosis is uncommon in Australian children, but is associated with substantial morbidity.

scholarly journals Successful Management of Nosocomial Ventriculitis and Meningitis Caused by Extensively Drug-ResistantAcinetobacter baumanniiin Austria

2013 ◽  
Vol 24 (3) ◽  
pp. e88-e90 ◽  
Author(s):  
M Hoenigl ◽  
M Drescher ◽  
G Feierl ◽  
T Valentin ◽  
G Zarfel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nosocomial Infections ◽  
Antimicrobial Agents ◽  
Northern Italy ◽  
Drug Resistant ◽  
Central Nervous System Infections ◽  
Successful Management ◽  
Gram Negative ◽  
Extensively Drug Resistant

Nosocomial infections caused by the Gram-negative coccobacillusAcinetobacter baumanniihave substantially increased over recent years. BecauseAcinetobacteris a genus with a tendency to quickly develop resistance to multiple antimicrobial agents, therapy is often complicated, requiring the return to previously used drugs. The authors report a case of meningitis due to extensively drug-resistantA baumanniiin an Austrian patient who had undergone neurosurgery in northern Italy. The case illustrates the limits of therapeutic options in central nervous system infections caused by extensively drug-resistant pathogens.

scholarly journals Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110409
Author(s):  
Griselda Berberian ◽  
Rosa Bologna ◽  
María Guadalupe Pérez ◽  
Andrea Mangano ◽  
Marina Costa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Infectious Diseases ◽  
Developmental Delay ◽  
Medical Records ◽  
Genetic Diseases ◽  
Pediatric Hospital ◽  
Clinical Presentations ◽  
Epidemiological Characteristics

There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%).

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