Rapid Source-Control Laparotomy: Is There a Mortality Benefit in Septic Shock?

2018 ◽  
Vol 19 (2) ◽  
pp. 225-229 ◽  
Author(s):  
James Vogler ◽  
Leslie Hart ◽  
Sharon Holmes ◽  
Jason D. Sciarretta ◽  
John Mihran Davis
Keyword(s):  
Septic Shock ◽  
Source Control ◽  
Mortality Benefit

RAPIDITY OF SOURCE CONTROL IMPLEMENTATION FOLLOWING ONSET OF HYPOTENSION IS A MAJOR DETERMINANT OF SURVIVAL IN HUMAN SEPTIC SHOCK

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A158 ◽  
Author(s):  
Anand Kumar ◽  
Murtaza Kazmi ◽  
John Ronald ◽  
Mustafa Seleman ◽  
Dan Roberts ◽  
...  
Keyword(s):  
Septic Shock ◽  
Major Determinant ◽  
Source Control ◽  
Human Septic Shock ◽  
Control Implementation

scholarly journals Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing Enterobacterales Infections: A Multicenter Nationwide Clinical Experience (CEFTABUSE II Study)

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Matteo Bassetti ◽  
Antonio Vena ◽  
Daniele Roberto Giacobbe ◽  
Marco Falcone ◽  
Giusy Tiseo ◽  
...  
Keyword(s):  
Septic Shock ◽  
Clinical Outcome ◽  
Standard Dose ◽  
Clinical Signs ◽  
Empiric Therapy ◽  
Source Control ◽  
Clinical Failure ◽  
Common Diagnosis ◽  
Definitive Therapy ◽  
Tract Infections

Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46, 30%), followed by 34 cases of complicated urinary tract infections (22.2%). Septic shock was observed in 42 (27.5%) patients. C/T was used as empiric therapy in 46 (30%) patients and as monotherapy in 127 (83%) patients. Favorable clinical outcome was observed in 128 (83.7%) patients; 25 patients were considered to have failed C/T therapy. Overall, 30-day mortality was reported for 15 (9.8%) patients. At multivariate analysis, Charlson comorbidity index >4 (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9–3.5; P = .02), septic shock (OR, 6.2; 95% CI, 3.8–7.9; P < .001), and continuous renal replacement therapy (OR, 3.1; 95% CI, 1.9–5.3; P = .001) were independently associated with clinical failure, whereas empiric therapy displaying in vitro activity (OR, 0.12; 95% CI, 0.01–0.34; P < .001) and adequate source control of infection (OR, 0.42; 95% CI, 0.14–0.55; P < .001) were associated with clinical success. Conclusions Data show that C/T could be a valid option in empiric and/or targeted therapy in patients with severe infections caused by ESBL-producing Enterobacterales. Clinicians should be aware of the risk of clinical failure with standard-dose C/T therapy in septic patients receiving CRRT.

Source control in the management of severe sepsis and septic shock: An evidence-based review

2004 ◽  
Vol 32 (Supplement) ◽  
pp. S513-S526 ◽  
Author(s):  
John C. Marshall ◽  
Ronald V. Maier ◽  
Maria Jimenez ◽  
E Patchen Dellinger
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Source Control ◽  
Evidence Based ◽  
Sepsis And Septic Shock

1271: A Meta-Analysis of Early Administration of Vasopressor in Septic Shock: Is There Mortality Benefit?

2020 ◽  
Vol 49 (1) ◽  
pp. 641-641
Author(s):  
David Gordon ◽  
Caleb Chan ◽  
Quincy Tran ◽  
Vera Bzhilyanskaya ◽  
Alexander Bracey ◽  
...  
Keyword(s):  
Septic Shock ◽  
Meta Analysis ◽  
Mortality Benefit ◽  
Early Administration

scholarly journals Recurring septic shock in a patient with blunt abdominal and pelvic trauma: how mandatory is source control surgery?: a case report

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Antonella Frattari ◽  
Giustino Parruti ◽  
Rocco Erasmo ◽  
Luigi Guerra ◽  
Ennio Polilli ◽  
...  
Keyword(s):  
Septic Shock ◽  
Case Report ◽  
Pelvic Trauma ◽  
Source Control

scholarly journals The impact of delayed source control and antimicrobial therapy in 196 patients with cholecystitis-associated septic shock: a cohort analysis

2019 ◽  
Vol 62 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Constantine J. Karvellas ◽  
Victor Dong ◽  
Juan G. Abraldes ◽  
Erica L.W. Lester ◽  
Anand Kumar
Keyword(s):  
Septic Shock ◽  
Antimicrobial Therapy ◽  
Cohort Analysis ◽  
Source Control ◽  
The Impact
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