Differential Impact of Infection Control Strategies on Rates of Resistant Hospital-Acquired Pathogens in Critically Ill Surgical Patients

2014 ◽  
Vol 15 (6) ◽  
pp. 726-732 ◽  
Author(s):  
Sudha P. Jayaraman ◽  
Reza Askari ◽  
Molli Bascom ◽  
Xiaoxia Liu ◽  
Selwyn O. Rogers ◽  
...  
Keyword(s):  
Infection Control ◽  
Critically Ill ◽  
Control Strategies ◽  
Surgical Patients ◽  
Differential Impact ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

Vitamin D Status Is Associated With Development of Hospital-Acquired Pressure Injuries in Critically Ill Surgical Patients

2018 ◽  
Vol 34 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Tiffany M. N. Otero ◽  
Cecilia Canales ◽  
D. Dante Yeh ◽  
Ali Elsayes ◽  
Donna M. Belcher ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critically Ill ◽  
Surgical Patients ◽  
Vitamin D Status ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

Systemic pharmacokinetics and safety of high doses of nebulized colistimethate sodium in critically ill patients with hospital-acquired and ventilator-associated pneumonia

2019 ◽  
Vol 74 (11) ◽  
pp. 3268-3273 ◽  
Author(s):  
Adela Benítez-Cano ◽  
Marta de Antonio-Cuscó ◽  
Sonia Luque ◽  
Luisa Sorlí ◽  
Jesús Carazo ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Case Series ◽  
Surgical Patients ◽  
Ventilator Associated Pneumonia ◽  
Colistimethate Sodium ◽  
High Doses ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

Abstract Objectives To assess the pharmacokinetics of formed colistin in plasma and the safety of two different high doses of colistimethate sodium administered via nebulization in critically ill surgical patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP). Patients and methods Formed colistin plasma concentrations were measured in critically ill surgical patients with pneumonia treated with two different doses of nebulized colistimethate sodium (3 MIU/8 h versus 5 MIU/8 h). Adverse events possibly related to nebulized colistimethate sodium were recorded. Results Twenty-seven patients (15 in the 3 MIU/8 h group and 12 in the 5 MIU/8 h group) were included. Colistin plasma concentrations were unquantifiable (<0.1 mg/L) in eight (53.3%) patients in the 3 MIU/8 h group and in seven patients (58.3%) in the 5 MIU/8 h group. Median (IQR) quantifiable colistin plasma concentrations before nebulization and at 1, 4 and 8 h were 0.17 (0.12–0.33), 0.20 (0.11–0.24), 0.17 (0.12–0.23) and 0.17 (0.11–0.32) mg/L, respectively, in the 3 MIU/8 h group and 0.20 (0.11–0.35), 0.24 (0.12–0.44), 0.24 (0.10–0.49) and 0.23 (0.11–0.44) mg/L, respectively, in the 5 MIU/8 h group, with no differences between the two groups at any time. Renal impairment during nebulized treatment was observed in three patients in each group, but was unlikely to be related to colistimethate sodium treatment. Nebulized colistimethate sodium therapy was well tolerated and no bronchospasms or neurotoxicity events were observed. Conclusions In this limited observational case series of critically ill patients with HAP or VAP treated with high doses of nebulized colistimethate sodium, systemic exposure was minimal and the treatment was well tolerated.

Group II phospholipase A2 in serum in critically ill surgical patients

1994 ◽  
Vol 22 (6) ◽  
pp. 956-959 ◽  
Author(s):  
JUHA M. GröNROOS ◽  
KARI KUTTILA ◽  
TIMO J. NEVALAJNEN
Keyword(s):  
Phospholipase A2 ◽  
Critically Ill ◽  
Surgical Patients ◽  
Group Ii ◽  
Critically Ill Surgical Patients

Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*

2007 ◽  
Vol 35 (11) ◽  
pp. 2538-2546 ◽  
Author(s):  
Baoli Cheng ◽  
Guohao Xie ◽  
ShangLong Yao ◽  
Xinmin Wu ◽  
Qulian Guo ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Surgical Patients ◽  
University Hospitals ◽  
Critically Ill Surgical Patients
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