Vitamin D Status Is Associated With Development of Hospital-Acquired Pressure Injuries in Critically Ill Surgical Patients

2018 ◽  
Vol 34 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Tiffany M. N. Otero ◽  
Cecilia Canales ◽  
D. Dante Yeh ◽  
Ali Elsayes ◽  
Donna M. Belcher ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critically Ill ◽  
Surgical Patients ◽  
Vitamin D Status ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

scholarly journals Prospective Study of Vitamin D Status at Initiation of Care in Critically Ill Surgical Patients and Risk of 90-Day Mortality*

2014 ◽  
Vol 42 (6) ◽  
pp. 1365-1371 ◽  
Author(s):  
Sadeq A. Quraishi ◽  
Edward A. Bittner ◽  
Livnat Blum ◽  
Caitlin M. McCarthy ◽  
Ishir Bhan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Prospective Study ◽  
Critically Ill ◽  
Surgical Patients ◽  
Vitamin D Status ◽  
Critically Ill Surgical Patients

Vitamin D deficiency and mortality among critically ill surgical patients in an urban Korean hospital

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Ji-hyun Lee ◽  
Seo-rin Doo ◽  
Dongha Kim ◽  
Yoo-kyoung Park ◽  
Eun-jeong Park ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Surgical Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Deficiency Group ◽  
Critically Ill Surgical Patients

Abstract. Critically ill patients in intensive care units (ICUs) are exposed to various risk factors for vitamin D deficiency. Vitamin D deficiency in extended-stay patients may result in decreased muscle mass and increased fat tissue, which may impair rehabilitation and recovery. Our study aimed to evaluate the degree of serum vitamin D deficiency in critically ill surgical patients and its association with clinical outcomes. Clinical data from 186 adult male (n = 121; 65.1%) and female (n = 65; 34.9%) patients hospitalized in surgical ICUs at Ajou University Hospital from April 2015 to September 2016 were retrospectively analyzed. All adult surgical patients between the age of 18 and 88 years were enrolled. The mean serum 25-hydroxyvitamin D (25[OH]D) level of all patients was 17.8 ng/mL. A total of 120 patients (64.5%) with serum 25(OH)D levels < 20 ng/mL were classified as the deficiency group. A prolonged hospital stay was observed among the deficiency group but was not statistically significant ( p = 0.824). Serum 25(OH)D levels were significantly correlated with age but inversely correlated with Sequential Organ Failure Assessment (SOFA) score, selenium, triglyceride, and C-reactive protein levels. There was no significant difference in mortality rates between the group with a vitamin D injection and the group without a vitamin D injection (14.6% vs. 16.9%, p = 0.074). Vitamin D deficiency was common in surgical ICU patients; however, vitamin D levels were higher in older patients. In conclusion, vitamin D deficiency was inversely associated with the SOFA severity score (Correlation Coefficient –0.165, p = 0.024) but was not associated with the length of hospital or ICU stay and mortality.

Systemic pharmacokinetics and safety of high doses of nebulized colistimethate sodium in critically ill patients with hospital-acquired and ventilator-associated pneumonia

2019 ◽  
Vol 74 (11) ◽  
pp. 3268-3273 ◽  
Author(s):  
Adela Benítez-Cano ◽  
Marta de Antonio-Cuscó ◽  
Sonia Luque ◽  
Luisa Sorlí ◽  
Jesús Carazo ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Case Series ◽  
Surgical Patients ◽  
Ventilator Associated Pneumonia ◽  
Colistimethate Sodium ◽  
High Doses ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

Abstract Objectives To assess the pharmacokinetics of formed colistin in plasma and the safety of two different high doses of colistimethate sodium administered via nebulization in critically ill surgical patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP). Patients and methods Formed colistin plasma concentrations were measured in critically ill surgical patients with pneumonia treated with two different doses of nebulized colistimethate sodium (3 MIU/8 h versus 5 MIU/8 h). Adverse events possibly related to nebulized colistimethate sodium were recorded. Results Twenty-seven patients (15 in the 3 MIU/8 h group and 12 in the 5 MIU/8 h group) were included. Colistin plasma concentrations were unquantifiable (<0.1 mg/L) in eight (53.3%) patients in the 3 MIU/8 h group and in seven patients (58.3%) in the 5 MIU/8 h group. Median (IQR) quantifiable colistin plasma concentrations before nebulization and at 1, 4 and 8 h were 0.17 (0.12–0.33), 0.20 (0.11–0.24), 0.17 (0.12–0.23) and 0.17 (0.11–0.32) mg/L, respectively, in the 3 MIU/8 h group and 0.20 (0.11–0.35), 0.24 (0.12–0.44), 0.24 (0.10–0.49) and 0.23 (0.11–0.44) mg/L, respectively, in the 5 MIU/8 h group, with no differences between the two groups at any time. Renal impairment during nebulized treatment was observed in three patients in each group, but was unlikely to be related to colistimethate sodium treatment. Nebulized colistimethate sodium therapy was well tolerated and no bronchospasms or neurotoxicity events were observed. Conclusions In this limited observational case series of critically ill patients with HAP or VAP treated with high doses of nebulized colistimethate sodium, systemic exposure was minimal and the treatment was well tolerated.

scholarly journals Impact of Hospital‐Acquired Infection on Vitamin D Status in Critically Ill Patients

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
B Peterson ◽  
J Alvarez ◽  
J Jones ◽  
G Hebbar ◽  
D Griffith ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Vitamin D Status ◽  
Hospital Acquired Infection ◽  
Hospital Acquired

Differential Impact of Infection Control Strategies on Rates of Resistant Hospital-Acquired Pathogens in Critically Ill Surgical Patients

2014 ◽  
Vol 15 (6) ◽  
pp. 726-732 ◽  
Author(s):  
Sudha P. Jayaraman ◽  
Reza Askari ◽  
Molli Bascom ◽  
Xiaoxia Liu ◽  
Selwyn O. Rogers ◽  
...  
Keyword(s):  
Infection Control ◽  
Critically Ill ◽  
Control Strategies ◽  
Surgical Patients ◽  
Differential Impact ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients

Effects of vitamin D deficiency in critically ill surgical patients

2012 ◽  
Vol 203 (3) ◽  
pp. 379-382 ◽  
Author(s):  
Lisa Flynn ◽  
Lisa Hall Zimmerman ◽  
Kelly McNorton ◽  
Mortimer Dolman ◽  
James Tyburski ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Surgical Patients ◽  
Critically Ill Surgical Patients

scholarly journals Vitamin D Status and the Risk for Hospital-Acquired Infections in Critically Ill Adults: A Prospective Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122136 ◽  
Author(s):  
Jordan A. Kempker ◽  
Kathryn G. West ◽  
Russell R. Kempker ◽  
Oranan Siwamogsatham ◽  
Jessica A. Alvarez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Critically Ill ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vitamin D Status ◽  
Hospital Acquired Infections ◽  
Critically Ill Adults ◽  
Hospital Acquired ◽  
Ill Adults
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