The Conundrum of the Gram-Positive Rod: Are We Missing Important Pathogens in Complicated Skin and Soft-Tissue Infections? A Case Report and Review of the Literature

2010 ◽  
Vol 11 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Tatyan M. Clarke ◽  
Diane M. Citron ◽  
Shirin Towfigh
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Infections ◽  
Review Of The Literature ◽  
Gram Positive ◽  
Complicated Skin

scholarly journals Telavancin Versus Standard Therapy for Treatment of Complicated Skin and Soft-Tissue Infections Due to Gram-Positive Bacteria

2005 ◽  
Vol 40 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
M. E. Stryjewski ◽  
W. D. O'Riordan ◽  
W. K. Lau ◽  
F. D. Pien ◽  
L. M. Dunbar ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Standard Therapy ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Complicated Skin

scholarly journals Tigecycline Susceptibility Trends Among Pathogens Isolated from Complicated Skin and Soft-Tissue Infections in North and Latin America: 2012–2016

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S108-S108
Author(s):  
Daryl Hoban ◽  
Martha Renteria ◽  
Heidi Leister-Tebbe ◽  
Dan Sahm
Keyword(s):  
Latin America ◽  
Soft Tissue ◽  
Geographic Region ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Complicated Skin ◽  
Trial Test ◽  
Organism Identification

Abstract Background The Tigecycline Evaluation Surveillance Trial (TEST) monitors the activity of tigecycline and other antimicrobials against clinically-relevant pathogens collected globally. This study reports the activity of tigecycline (TGC) against Gram-positive and Gram-negative isolates collected in North and Latin America from patients with complicated skin and soft-tissue infections (CSSTI). Methods Hospital sites from North America (NA) and Latin America (LA) collected non-duplicate clinical Gram-positive and -negative isolates from various complicated skin and skin structure infection sources during 2012–2016. Organism identification and antibiotic susceptibility (S) testing was performed by the local laboratories. Susceptibility testing was determined using the broth microdilution method according to CLSI guidelines and categorical interpretation of results was done using CLSI or FDA (tigecycline) breakpoint criteria where appropriate. Cefoxitin disk testing was performed for all S. aureus to determine methicillin susceptibility (i.e., MRSA and MSSA). Results The table provides %S and MIC90 data for TGC against CSSTI isolates Conclusion Based on %S and MIC90 data TGC exhibited potent activity against isolates of all organism groups from complicated skin and soft-tissue infections, regardless of the geographic region. However, given the potential many of these organisms have for developing resistance, continued and careful surveillance monitoring is warranted. Disclosures M. Renteria, IHMA, Inc.: Employee, Salary. H. Leister-Tebbe, Pfizer: Employee, Salary

Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections

2020 ◽  
Vol 19 (3) ◽  
pp. 236-241 ◽  
Author(s):  
Vasilios Petrakis ◽  
Periklis Panagopoulos ◽  
Nikolaos Papanas
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Treatment ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Positive Skin ◽  
Methicillin Resistant ◽  
Complicated Skin

New antimicrobial agents have been developed to treat infections caused by methicillin-resistant Staphylococcus aureus and other multidrug-resistant pathogens. Dalbavancin is a novel semisynthetic lipoglycopeptide antibiotic, particularly active against methicillin-resistant Staphylococcus aureus. Due to its unique pharmacological characteristics and longer half-life, it can be administered once-weekly or every 15 days and in outpatient setting. Currently, it is indicated for complicated skin and soft tissue infections, but accumulating evidence points to its off-label efficacy in osteomyelitis and endocarditis. Further experience is still needed to increase our knowledge on the role of dalbavancin in a wider range of Gram-positive infections requiring prolonged antimicrobial treatment.

scholarly journals Disseminated Mycobacterium abscessus Infection Secondary to an Infected Vascular Stent: Case Report and Review of the Literature

2018 ◽  
Vol 5 (9) ◽  
Author(s):  
Nilesh Tejura ◽  
Gilda Bontempo ◽  
Debra Chew
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Rare Case ◽  
Multidrug Resistant ◽  
Mycobacterium Abscessus ◽  
Soft Tissue Infections ◽  
Endovascular Stent ◽  
Review Of The Literature ◽  
Vascular Stent

Abstract Mycobacterium abscessus is a rapidly growing, multidrug-resistant mycobacteria, commonly associated with pulmonary, skin, and soft tissue infections. We describe a rare case of M abscessus endovascular stent infection; only 3 cases of graft infections have previously been reported.

Case Report: When all claims that it is necrotizing fasciitis but Point of care ultrasound (POCUS) proves the opposite!

POCUS Journal ◽  
2018 ◽  
Vol 3 (1) ◽  
pp. 13-14
Author(s):  
Hadiel Kaiyasah, MD, MRCS (Glasgow), ABHS-GS ◽  
Maryam Al Ali, MBBS
Keyword(s):  
Emergency Department ◽  
Critical Care ◽  
Case Report ◽  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Soft Tissue Infection ◽  
Critical Care Unit ◽  
Point Of Care ◽  
Point Of Care Ultrasound ◽  
Soft Tissue Infections

Soft tissue ultrasound (ST-USS) has been shown to be of utmost importance in assessing patients with soft tissue infections in the emergency department or critical care unit. It aids in guiding the management of soft tissue infection based on the sonographic findings.

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