scholarly journals Telavancin Versus Standard Therapy for Treatment of Complicated Skin and Soft-Tissue Infections Due to Gram-Positive Bacteria

2005 ◽  
Vol 40 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
M. E. Stryjewski ◽  
W. D. O'Riordan ◽  
W. K. Lau ◽  
F. D. Pien ◽  
L. M. Dunbar ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Standard Therapy ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Complicated Skin

scholarly journals Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2354 ◽  
Author(s):  
Oscar Forero Doria ◽  
Ricardo Castro ◽  
Margarita Gutierrez ◽  
Diego Gonzalez Valenzuela ◽  
Leonardo Santos ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquids ◽  
Soft Tissue ◽  
Inhibitory Concentration ◽  
Membrane Surface ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Antibacterial Screening ◽  
Mic Value

Keeping in mind the concept of green chemistry, this research aims to synthesize and characterize new ionic liquids (ILs) derived from N-cinnamyl imidazole with different sizes of alkyl chains (1, 6, 8, and 10 carbon atoms), and evaluate their antibacterial activity against Skin and soft tissue infections (SSTIs) causative bacteria. The antibacterial screening was carried out by agar well diffusion and the Minimum Inhibitory Concentration (MIC) and Half Maximum Inhibitory Concentration (IC50) of the different ILs were determined by microdilution in broth, also Molecular dynamics simulations were performed to study the interaction mechanism between ILs and membranes. The MIC value in Gram-positive bacteria showed that as the hydrocarbon chain increases, the MIC value decreases with a dose-dependent effect. Furthermore, Gram-negative bacteria showed high MIC values, which were also evidenced in the antibacterial screening. The molecular dynamics showed an incorporation of the ILs with the longer chain (10 C), corresponding to a passive diffusion towards the membrane surface, for its part, the ILs with the shorter chain due to its lack of hydrophobicity was not incorporated into the bilayer. Finally, the new ILs synthesized could be an alternative for the treatment of Gram-positive bacteria causative of SSTIs.

Daptomycin (Cubicin) in patients with complicated skin or soft-tissue infections

2008 ◽  
Vol 9 (3) ◽  
pp. 163-166
Author(s):  
Viola Sacchi
Keyword(s):  
Soft Tissue ◽  
Clinical Characteristics ◽  
Bacterial Resistance ◽  
Surgical Intervention ◽  
Progressive Increase ◽  
Soft Tissue Infections ◽  
Aetiological Agent ◽  
Gram Positive Bacteria ◽  
Co Morbidity ◽  
Complicated Skin

Skin and soft-tissue infections (SSTIs) are commonly observed and differ in terms of site and localization, clinical characteristics, and the aetiological agent; these infections are usually caused by Staphylococcus aureus or beta-haemolytic streptococci, and are the most frequent forms of methicillin-resistant S. aureus (MRSA) infections. SSTIs are considered complicated if they involve deeper skin structures (fascia or muscle layers), require significant surgical intervention or arise in the presence of significant co-morbidity. The progressive increase of bacterial resistance, in particular for Gram-positive bacteria infections, to currently used agents is a serious and growing problem, and in particular MRSA, GISA (glycopeptides-insusceptible S. aureus), VRE and GRE (glycopeptides-resistant enterococci) are of concern. There is, therefore, a need for additional agents active against these difficult-to-treat pathogens.

scholarly journals Tigecycline Susceptibility Trends Among Pathogens Isolated from Complicated Skin and Soft-Tissue Infections in North and Latin America: 2012–2016

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S108-S108
Author(s):  
Daryl Hoban ◽  
Martha Renteria ◽  
Heidi Leister-Tebbe ◽  
Dan Sahm
Keyword(s):  
Latin America ◽  
Soft Tissue ◽  
Geographic Region ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Complicated Skin ◽  
Trial Test ◽  
Organism Identification

Abstract Background The Tigecycline Evaluation Surveillance Trial (TEST) monitors the activity of tigecycline and other antimicrobials against clinically-relevant pathogens collected globally. This study reports the activity of tigecycline (TGC) against Gram-positive and Gram-negative isolates collected in North and Latin America from patients with complicated skin and soft-tissue infections (CSSTI). Methods Hospital sites from North America (NA) and Latin America (LA) collected non-duplicate clinical Gram-positive and -negative isolates from various complicated skin and skin structure infection sources during 2012–2016. Organism identification and antibiotic susceptibility (S) testing was performed by the local laboratories. Susceptibility testing was determined using the broth microdilution method according to CLSI guidelines and categorical interpretation of results was done using CLSI or FDA (tigecycline) breakpoint criteria where appropriate. Cefoxitin disk testing was performed for all S. aureus to determine methicillin susceptibility (i.e., MRSA and MSSA). Results The table provides %S and MIC90 data for TGC against CSSTI isolates Conclusion Based on %S and MIC90 data TGC exhibited potent activity against isolates of all organism groups from complicated skin and soft-tissue infections, regardless of the geographic region. However, given the potential many of these organisms have for developing resistance, continued and careful surveillance monitoring is warranted. Disclosures M. Renteria, IHMA, Inc.: Employee, Salary. H. Leister-Tebbe, Pfizer: Employee, Salary

Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections

2020 ◽  
Vol 19 (3) ◽  
pp. 236-241 ◽  
Author(s):  
Vasilios Petrakis ◽  
Periklis Panagopoulos ◽  
Nikolaos Papanas
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Treatment ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Positive Skin ◽  
Methicillin Resistant ◽  
Complicated Skin

New antimicrobial agents have been developed to treat infections caused by methicillin-resistant Staphylococcus aureus and other multidrug-resistant pathogens. Dalbavancin is a novel semisynthetic lipoglycopeptide antibiotic, particularly active against methicillin-resistant Staphylococcus aureus. Due to its unique pharmacological characteristics and longer half-life, it can be administered once-weekly or every 15 days and in outpatient setting. Currently, it is indicated for complicated skin and soft tissue infections, but accumulating evidence points to its off-label efficacy in osteomyelitis and endocarditis. Further experience is still needed to increase our knowledge on the role of dalbavancin in a wider range of Gram-positive infections requiring prolonged antimicrobial treatment.

Microbial Distribution and Antibiotic Susceptibility in Patients with Complicated Skin and Soft Tissue Infections of the Extremities in North-Eastern China

2020 ◽  
Author(s):  
Jie Ma ◽  
Yanqing Song ◽  
Xiangfeng Wang ◽  
Huiyu Yan ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Antibiotic Susceptibility ◽  
Eastern China ◽  
Severe Infection ◽  
Soft Tissue Infections ◽  
Gram Positive Bacteria ◽  
Microbial Distribution ◽  
Complicated Skin ◽  
North Eastern

Abstract Background For complicated skin and soft tissue infections (cSSTIs), inappropriate initial anti-infective treatment often leads to treatment failure. The microbial distribution in patients with extremities’ cSSTIs has been rarely reported. Moreover, whether gram-negative bacteria (GNB) should be covered in addition to gram-positive bacteria (GPB) has been always a difficult issue in the treatment of cSSTIs. Methods We retrospectively analyzed the microbial distribution and antibiotic susceptibility in 149 hospitalized patients with extremities’ SSTIs, and discussed the risk factors of extremities’ cSSTIs caused by GNB. Results 188 strains of pathogens were isolated, including 113 strains of GPB (64.9%), 61 strains of GNB (32.4%), and 5 strains of fungi (2.7%). Diabetes mellitus (OR=3.606, P =0.034), SSTI severity [moderate infection (OR=19.499, P <0.0001), severe infection (OR=20.114, P <0.0001)], and necrotizing infection (OR=6.064, P <0.0001) were risk factors of extremities’ cSSTIs caused by GNB. For patients with risk factors, ceftazidime, cefepime, piperacillin/tazobactam and carbapenems could be empirical anti-infective agents. Conclusions The results of our study showed that the most common bacteria identified in cSSTIs of the extremities were GPB. For patients with risk factors of extremities’ cSSTIs caused by GNB, the coverage of GNB should be taken into account.

Randomized Comparison Trial of Teicoplanin IV, Teicoplanin IM, and Cefazolin Therapy for Skin and Soft Tissue Infections Caused by Gram-Positive Bacteria

1994 ◽  
Vol 87 (9) ◽  
pp. 875-880 ◽  
Author(s):  
VALERIE A. CHIRURGI ◽  
HOWARD EDELSTEIN ◽  
SHARON E. OSTER ◽  
RICHARD KARP ◽  
KAREN B. CASSANO ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Comparison Trial
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