Cell Replacement Therapy in the Inner Ear

2006 ◽  
Vol 15 (3) ◽  
pp. 449-459 ◽  
Author(s):  
Zhengqing Hu ◽  
Mats Ulfendahl
Keyword(s):  
Replacement Therapy ◽  
Inner Ear ◽  
Cell Replacement Therapy ◽  
Cell Replacement

Cell Replacement Therapy in the Inner Ear: Implications for Cochlear Implantation

2009 ◽  
Vol 19 (2) ◽  
pp. 98-107
Author(s):  
Katherine A. Belzner ◽  
Brenda M. Ryals
Keyword(s):  
Hearing Loss ◽  
Growth Factors ◽  
Animal Models ◽  
Hair Cell ◽  
Replacement Therapy ◽  
Inner Ear ◽  
Critical Role ◽  
Future Application ◽  
Cell Replacement Therapy ◽  
Cell Replacement

Abstract This article provides an overview of recent advances in inner ear cell replacement therapy. Current strategies designed both to initiate hair cell regeneration and maintain or regenerate neural cells are reviewed. Using animal models, investigators have shown that hearing loss from hair cell and neural degeneration can be reversed through molecular and genetic manipulation. Successful strategies in animal models have included the use of growth factors, stem cells, and gene therapy. One significant challenge for the use of these strategies in humans is the development of safe, efficient, and targeted drug delivery systems. Using animal models investigators have shown that cochlear implants can be used to deliver growth factors, such as neurotrophins to the inner ear. Targeting the appropriate neural elements will be important for future application of this technique in humans. Finally, the prognosis for hearing restoration through cell replacement or maintenance therapy will certainly be influenced by the underlying etiology of the hearing loss. Audiologists will play a critical role in the future determination of candidacy for these therapeutic approaches.

scholarly journals Functional Evaluation of a Cell Replacement Therapy in the Inner Ear

2009 ◽  
Vol 30 (4) ◽  
pp. 551-558 ◽  
Author(s):  
Zhengqing Hu ◽  
Mats Ulfendahl ◽  
Diane M. Prieskorn ◽  
Petri Olivius ◽  
Josef M. Miller
Keyword(s):  
Replacement Therapy ◽  
Inner Ear ◽  
Functional Evaluation ◽  
Cell Replacement Therapy ◽  
Cell Replacement ◽  
A Cell

A microfluidic platform enables comprehensive gene expression profiling of mouse retinal stem cells

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Shana O Kelley ◽  
Mahmoud Labib ◽  
Brenda Coles ◽  
Mahla Poudineh ◽  
Brendan Innes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Stem Cell ◽  
Visual Impairment ◽  
Gene Expression Profiling ◽  
Replacement Therapy ◽  
Retinal Degeneration ◽  
Expression Profiling ◽  
Cell Replacement Therapy ◽  
Cell Replacement

Loss of photoreceptors due to retinal degeneration is a major cause of untreatable visual impairment and blindness. Cell replacement therapy, using retinal stem cell (RSC)-derived photoreceptors, holds promise for reconstituting...

scholarly journals ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro

2021 ◽  
Author(s):  
Fiona M. Docherty ◽  
Kent A. Riemondy ◽  
Roberto Castro-Gutierrez ◽  
JaeAnn M. Dwulet ◽  
Ali H. Shilleh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Replacement Therapy ◽  
Beta Cells ◽  
Nucleoside Triphosphate ◽  
Specific Marker ◽  
Detailed Knowledge ◽  
Cell Replacement Therapy ◽  
Mature Adult ◽  
Cell Replacement

Stem cell derived beta-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. To achieve their clinical promise, sBC need to function comparably to mature adult beta cells, but as yet they display varying degrees of maturity. Indeed, detailed knowledge of the events resulting in human beta cell maturation remains obscure. Here we show that sBC spontaneously self-enrich into discreet islet-like cap structures within <i>in vitro</i> cultures, independent of exogenous maturation conditions. Multiple complementary assays demonstrate that this process is accompanied by functional maturation of the self-enriched sBC (seBC); however, the seBC still contain distinct subpopulations displaying different maturation levels. Interestingly, the surface protein ENTPD3 (also known as nucleoside triphosphate diphosphohydrolase-3 (NDPTase3)) is a specific marker of the most mature seBC population and can be used for mature seBC identification and sorting. Our results illuminate critical aspects of <i>in vitro</i> sBC maturation and provide important insights towards developing functionally mature sBC for diabetes cell replacement therapy.

scholarly journals Ca(2+) Oscillations and Its Transporters in Mesenchymal Stem Cells

2010 ◽  
pp. 323-329 ◽  
Author(s):  
B Ye
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Replacement Therapy ◽  
Cell Types ◽  
Cell Replacement Therapy ◽  
Cell Replacement ◽  
Cell Functions ◽  
The Past ◽  
Intracellular Ca

Intracellular free Ca(2+) is one of important biological signals regulating a number of cell functions. It has been discussed widely and extensively in several cell types during the past two decades. Attention has been paid to the Ca2+ transportation in mesenchymal stem cells in recent years as mesenchymal stem cells have gained considerable interest due to their potential for cell replacement therapy and tissue engineering. In this paper, roles of intracellular Ca(2+) oscillations and its transporters in mesenchymal stem cells have been reviewed.

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