Inhaled Corticosteroids versus Leukotriene Receptor Antagonists as First-line Therapy for Mild Persistent Asthma in Children?

2005 ◽  
Vol 18 (4) ◽  
pp. 259-263 ◽  
Author(s):  
H. William Kelly
Keyword(s):  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
First Line ◽  
Receptor Antagonists ◽  
Leukotriene Receptor Antagonists ◽  
First Line Therapy ◽  
Line Therapy ◽  
Leukotriene Receptor ◽  
Asthma In Children ◽  
Mild Persistent Asthma

scholarly journals Montelukast versus inhaled corticosteroids in the management of pediatric mild persistent asthma

2012 ◽  
Vol 7 ◽  
Author(s):  
Alessandra Scaparrotta ◽  
Sabrina Di Pillo ◽  
Marina Attanasi ◽  
Daniele Rapino ◽  
Anna Cingolani ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Jadad Score ◽  
First Line ◽  
Poor Growth ◽  
Asthmatic Children ◽  
Randomized Controlled ◽  
Pediatric Populations ◽  
Leukotriene Receptor ◽  
Mild Persistent Asthma

International guidelines recommend the use of inhaled corticosteroids (ICSs) as the preferred therapy, with leukotriene receptor antagonists (LTRAs) as an alternative, for the management of persistent asthma in children. Montelukast (MLK) is the first LTRA approved by the Food and Drug Administration for the use in young asthmatic children. Therefore, we performed an analysis of studies that compared the efficacy of MLK versus ICSs. We considered eligible for the inclusion randomized, controlled trials on pediatric populations with Jadad score>3, with at least 4 weeks of treatment with MLK compared with ICS. Although it is important to recognize that ICSs use is currently the recommended first-line treatment for asthmatic children, MLK can have consistent benefits in controlling asthmatic symptoms and may be an alternative in children unable to use ICSs or suffering from poor growth. On the contrary, low pulmonary function and/or high allergic inflammatory markers require the corticosteroid use.

Treatment Persistence with Leukotriene Receptor Antagonists and Inhaled Corticosteroids

2005 ◽  
Vol 42 (5) ◽  
pp. 385-393 ◽  
Author(s):  
Marc Dorais ◽  
Lucie Blais ◽  
Isabelle Chabot ◽  
Jacques LeLorier
Keyword(s):  
Inhaled Corticosteroids ◽  
Receptor Antagonists ◽  
Treatment Persistence ◽  
Leukotriene Receptor Antagonists ◽  
Leukotriene Receptor
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