Role of Serum Eosinophil Cationic Protein in the Monitoring of Children with Bronchial Asthma and Rhinitis

1998 ◽  
Vol 12 (2) ◽  
pp. 129-138 ◽  
Author(s):  
WEN-YI LEE ◽  
MEI-HUI YANG ◽  
LI-CHEN CHEN ◽  
SYH-JAE LIN ◽  
JING-LONG HUANG
Allergy ◽  
1994 ◽  
Vol 49 (9) ◽  
pp. 730-736 ◽  
Author(s):  
E. Björnsson ◽  
C. Janson ◽  
L. Håkansson ◽  
I. Enander ◽  
P. Venge ◽  
...  

2001 ◽  
Vol 95 (8) ◽  
pp. 670-675 ◽  
Author(s):  
B. SCHMEKEL ◽  
J. AHLNER ◽  
M. MALMSTRÖM ◽  
P. VENGE

2011 ◽  
Vol 49 (01) ◽  
pp. 35-37
Author(s):  
Takahiko Horiguchi ◽  
Soichi Tachikawa ◽  
Junichi Kasahara ◽  
Masashi Doi ◽  
Mamoru Shiga

2003 ◽  
Vol 22 (3) ◽  
pp. 249-253
Author(s):  
Snezana Kovacevic ◽  
Mirjana Bogic ◽  
Aleksandra Peric-Popadic ◽  
Sanvila Raskovic ◽  
Zikica Jovicic ◽  
...  

Activated eosinophilic leukocyte in asthma secretes numerous mediators, among which is ECP as well. The object of our study was to measure the serum ECP concentrations in 46 asthmatic patients with exacerabating and stable asthma, and to correlate the serum ECP concentrations with severity and exacerbation of the disease. Geometric mean of ECP in serum (Gecp) in our group of patients was 7.5 mcg/l, while it was 3.05 mcg/l in the 15 healthy subjects (controls). Highly significant correlation of serum ECP concentrations with the activity of the disease (R=0.897) and the severity of clinical picture (R=0.79) was found. The patients with stable asthma had significant correlation of ECP and the severity of disease (R=0.6). The patients with exacerbating asthma have significantly higher serum ECP concentrations than the patients with stable asthma. Serum ECP concentrations in patients with exacerbating asthma correlate with the severity of the disease.


2005 ◽  
Vol 33 (6) ◽  
pp. 668-676
Author(s):  
T Horiguchi ◽  
J Miyazaki ◽  
D Ohira ◽  
Y Watanabe ◽  
N Hayashi ◽  
...  

The efficacy of Sparfloxacin (SPFX) for the control of bronchial asthma was evaluated in 26 patients with suspected Chlamydia pneumoniae infection. Patients were randomly allocated to receive SPFX 200 mg/day (n = 14) or control treatment (n = 12) for 21 days. Significant improvements in serum C-reactive protein levels, and significant decreases in peripheral eosinophil counts, serum eosinophil cationic protein (ECP) and sputum ECP were observed in the SPFX-treated group at day 21. SPFX-treated patients also had a significantly reduced frequency of asthma symptoms, reduced inhalant β2-stimulant use, and significant increases in morning peak expiratory flow. At the end of the study, C. pneumoniae was undetectable in two SPFX-treated patients who underwent polymerase chain reaction testing, but one control patient who was tested still had detectable levels of C. pneumoniae. These results suggest that SPFX could be used to control bronchial asthma in patients with suspected persistent C. pneumoniae infection.


2011 ◽  
Vol 56 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Michele Conceição Pereira ◽  
Denise Tostes Oliveira ◽  
Luiz Paulo Kowalski

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