Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment “jigsaw puzzle”

2019 ◽  
Vol 23 (2) ◽  
pp. 70-85 ◽  
Author(s):  
Kevin Dzobo
Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 940
Author(s):  
Chaojie Zhu ◽  
Zhiheng Ji ◽  
Junkai Ma ◽  
Zhijie Ding ◽  
Jie Shen ◽  
...  

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.


F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 470 ◽  
Author(s):  
Mohamed Mahmoud ◽  
Keira P. Mason

Anesthesiology, as a field, has made promising advances in the discovery of novel, safe, effective, and efficient methods to deliver care. This review explores refinement in the technology of soft drug development, unique anesthetic delivery systems, and recent drug and device failures.


2017 ◽  
Vol 108 (5) ◽  
pp. 831-837 ◽  
Author(s):  
Yuki Yamamoto ◽  
Masaki Nagasato ◽  
Teruhiko Yoshida ◽  
Kazunori Aoki

2019 ◽  
Vol 50 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Phuong Tran ◽  
Sang-Eun Lee ◽  
Dong-Hyun Kim ◽  
Yong-Chul Pyo ◽  
Jeong-Sook Park

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