Recent advances on small‐molecule nanomedicines for cancer treatment

2020 ◽  
Vol 12 (3) ◽  
Author(s):  
Xiangdong Xue ◽  
Aaron Lindstrom ◽  
Haijing Qu ◽  
Yuanpei Li
Keyword(s):  
Cancer Treatment ◽  
Small Molecule ◽  
Recent Advances

scholarly journals Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuan Ma ◽  
Sifan Yu ◽  
Shuaijian Ni ◽  
Baoxian Zhang ◽  
Angela Chun Fai Kung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Small Molecule ◽  
Tumor Targeting ◽  
Water Solubility ◽  
Individualized Treatment ◽  
Selective Toxicity ◽  
Poor Solubility ◽  
Recent Advances ◽  
Tumor Recognition ◽  
Tumor Specificity

Paclitaxel (PTX) has been used for cancer treatment for decades and has become one of the most successful chemotherapeutics in the clinic and financially. However, serious problems with its use still exist, owing to its poor solubility and non-selective toxicity. With respect to these issues, recent advances have addressed the water solubility and tumor specificity related to PTX application. Many measures have been proposed to remedy these limitations by enhancing tumor recognition via ligand-receptor-mediated targeting as well as other associated strategies. In this review, we investigated various kinds of ligands that have emerged as PTX tumor-targeting tools. In particular, this article highlights small molecule-, protein-, and aptamer-functionalized conjugates and nanoparticles (NPs), providing a promising approach for PTX-based individualized treatment prospects.

Recent Advances of p53-MDM2 Small Molecule Inhibitors (2011-Present)

2015 ◽  
Vol 22 (5) ◽  
pp. 618-626 ◽  
Author(s):  
Peng-Cheng Lv ◽  
Juan Sun ◽  
Hai-Liang Zhu
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Recent Advances

scholarly journals Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 940
Author(s):  
Chaojie Zhu ◽  
Zhiheng Ji ◽  
Junkai Ma ◽  
Zhijie Ding ◽  
Jie Shen ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Cancer Treatments ◽  
Recent Advances ◽  
Therapeutic Mechanisms ◽  
Bacterial Therapy ◽  
Targeting Ability ◽  
Drug And Gene Delivery

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.

scholarly journals Recent advances in developing small-molecule inhibitors against SARS-CoV-2

2021 ◽  
Author(s):  
Rong Xiang ◽  
Zhengsen Yu ◽  
Yang Wang ◽  
Lili Wang ◽  
Shanshan Huo ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Recent Advances

scholarly journals Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

2021 ◽  
Vol 50 (2) ◽  
pp. 702-734
Author(s):  
Luling Wu ◽  
Jihong Liu ◽  
Ping Li ◽  
Bo Tang ◽  
Tony D. James
Keyword(s):  
Small Molecule ◽  
Biological Systems ◽  
Two Photon ◽  
Small Molecule Probes ◽  
Recent Advances ◽  
Design Construction

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes.

Tuning metal–metal interactions for cooperative small molecule activation

2021 ◽  
Author(s):  
Qiuran Wang ◽  
Sam H. Brooks ◽  
Tianchang Liu ◽  
Neil C. Tomson
Keyword(s):  
Small Molecule ◽  
Small Molecule Activation ◽  
Feature Article ◽  
Metal Interactions ◽  
Recent Advances ◽  
Metal Metal

This Feature Article describes recent advances in the design of multinucleating ligands that support small molecule activation chemistry.

scholarly journals Small-molecule fluorescence-based probes for interrogating major organ diseases

2021 ◽  
Author(s):  
Hai-Hao Han ◽  
He Tian ◽  
Yi Zang ◽  
Adam C. Sedgwick ◽  
Jia Li ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Advances ◽  
Major Organ

This tutorial review describes recent advances involving small molecule fluorescent probes designed to aid in the study of major organ diseases.

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