Biomarkers in Tumor Microenvironment? Upregulation of Fibroblast Activation Protein-α Correlates with Gastric Cancer Progression and Poor Prognosis

2017 ◽  
Vol 21 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Mengmou Hu ◽  
Chengjia Qian ◽  
Ziwei Hu ◽  
Bojian Fei ◽  
Haibo Zhou
Keyword(s):  
Gastric Cancer ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation ◽  
Gastric Cancer Progression

scholarly journals Fibroblast Activation Protein-α-Positive Fibroblasts Promote Gastric Cancer Progression and Resistance to Immune Checkpoint Blockade

2017 ◽  
Vol 25 (4) ◽  
pp. 629-640 ◽  
Author(s):  
Xuyang Wen ◽  
Xiaoping He ◽  
Feng Jiao ◽  
Chunhui Wang ◽  
Yang Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Microenvironment ◽  
Cell Lines ◽  
Cancer Progression ◽  
Immune Checkpoint ◽  
Fibroblast Activation Protein ◽  
Cancer Associated Fibroblasts ◽  
Antitumor Effects ◽  
Fibroblast Activation

Gastric cancer (GC) is one of the main causes of cancer death. The tumor microenvironment has a profound effect on inducing tumor growth, metastasis, and immunosuppression. Fibroblast activation protein-α (FAP) is a protein that is usually expressed in fibroblasts, such as cancer-associated fibroblasts, which are major components of the tumor microenvironment. However, the role of FAP in GC progression and treatment is still unknown. In this study, we explored these problems based on GC patient samples and experimental models. We found that high FAP expression was an independent prognosticator of poor survival in GC patients. FAP+ cancer-associated fibroblasts (CAFs) promoted the survival, proliferation, and migration of GC cell lines in vitro. Moreover, they also induced drug resistance of the GC cell lines and inhibited the antitumor functions of T cells in the GC tumor microenvironment. More importantly, we found that targeting FAP+ CAFs substantially enhanced the antitumor effects of immune checkpoint blockades in GC xenograft models. This evidence highly suggested that FAP is a potential prognosticator of GC patients and a target for synergizing with other treatments, especially immune checkpoint blockades in GC.

scholarly journals The Emerging Role of GC-MSCs in the Gastric Cancer Microenvironment: From Tumor to Tumor Immunity

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Zhaoji Pan ◽  
Yiqing Tian ◽  
Guoping Niu ◽  
Chengsong Cao
Keyword(s):  
Gastric Cancer ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Wound Repair ◽  
Critical Role ◽  
The Novel ◽  
Potential Biomarker ◽  
Underlying Mechanisms ◽  
Gastric Cancer Progression

Mesenchymal stem cells (MSCs) have been declared to not only participate in wound repair but also affect tumor progression. Tumor-associated MSCs, directly existing in the tumor microenvironment, play a critical role in tumor initiation, progression, and development. And different tumor-derived MSCs have their own unique characteristics. In this review, we mainly describe and discuss recent advances in our understanding of the emerging role of gastric cancer-derived MSC-like cells (GC-MSCs) in regulating gastric cancer progression and development, as well as the bidirectional influence between GC-MSCs and immune cells of the tumor microenvironment. Moreover, we also discuss the potential biomarker and therapeutic role of GC-MSCs. It is anticipated that new and deep insights into the functionality of GC-MSCs and the underlying mechanisms will promote the novel and promising therapeutic strategies against gastric cancer.

scholarly journals FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis

2020 ◽  
Vol 21 (9) ◽  
pp. 815-825
Author(s):  
Hua Fan ◽  
Shengjun Zhang ◽  
Yu Zhang ◽  
Wu liang ◽  
Bo Cao
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Gastric Cancer Progression

scholarly journals Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis

2017 ◽  
Vol 37 (1) ◽  
pp. 191-196 ◽  
Author(s):  
NORIMICHI KOGURE ◽  
TAKEHIKO YOKOBORI ◽  
KYOICHI OGATA ◽  
BOLAG ALTAN ◽  
ERITO MOCHIKI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Gastric Cancer Progression ◽  
Low Expression

scholarly journals SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Yusufu Maimaiti ◽  
Maimaitiaili Maimaitiming ◽  
Yiliang Li ◽  
Saifuding Aibibula ◽  
Azatijiang Ainiwaer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Gastric Cancer Progression

MAGE-A family is involved in gastric cancer progression and indicates poor prognosis of gastric cancer patients

2017 ◽  
Vol 213 (8) ◽  
pp. 943-948 ◽  
Author(s):  
Yishui Lian ◽  
Meixiang Sang ◽  
Lina Gu ◽  
Fei Liu ◽  
Danjing Yin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Gastric Cancer Patients ◽  
Gastric Cancer Progression

scholarly journals MiR-1284 suppresses gastric cancer progression by targeting EIF4A1

2019 ◽  
Vol Volume 12 ◽  
pp. 3965-3976 ◽  
Author(s):  
Weiyuan Wei ◽  
Wenlong Cao ◽  
Zexu Zhan ◽  
Linhai Yan ◽  
Yubo Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Gastric Cancer Progression
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