scholarly journals Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Takayuki Ishige ◽  
Motoi Nishimura ◽  
Mamoru Satoh ◽  
Mai Fujimoto ◽  
Masaki Fukuyo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Diffuse Type ◽  
Fibroblast Activation ◽  
Diffuse Type Gastric Cancer ◽  
Gastric Cancer Progression

scholarly journals Asporin Expression on Stromal Cells and/or Cancer Cells Might Be A Useful Prognostic Marker in Patients with Diffuse-Type Gastric Cancer

2021 ◽  
pp. 1-8
Author(s):  
Masakazu Yashiro ◽  
Tsuyoshi Hasegawa ◽  
Yurie Yamamoto ◽  
Gen Tsujio ◽  
Sadaaki Nishimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Cells ◽  
Prognostic Marker ◽  
Cancer Progression ◽  
Stromal Cells ◽  
Intestinal Type ◽  
Human Gastric Cancer ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer

<b><i>Background:</i></b> Asporin (ASPN), a member of the proteoglycan family, has been shown to have a close correlation with cancer progression. It is not known whether ASPN is an oncogenic driver or a tumor suppressor in human gastric cancer. We sought herein to determine the relationship between ASPN expression and clinicopathological features of gastric cancer. <b><i>Patients and Methods:</i></b> A total of 296 gastric cancer patients (diffuse type, <i>n</i> = 144; intestinal type, <i>n</i> = 152) were enrolled. The ASPN expression level in each case was analyzed by immunohistochemistry. <b><i>Results:</i></b> ASPN was mainly found on stromal cells, especially on fibroblasts in tumor stroma, i.e., cancer-associated fibroblasts. The ASPN expression on either cancer cells or stromal cells was significantly high in macroscopic scirrhous-type tumors (<i>p</i> &#x3c; 0.001) and histologically abundant stroma-type tumors (<i>p</i> &#x3c; 0.001). Interestingly, a Kaplan-Meier survival curve of the 144 cases of diffuse-type gastric cancer revealed a significantly poorer prognosis in patients with ASPN-positive expression (<i>p</i> = 0.043; log rank) compared to those with ASPN-negative expression, but the prognoses were not significantly different in these subgroups of the 152 cases of intestinal-type gastric cancer. A multivariate analysis with respect to overall survival showed that ASPN expression on stromal cells and/or cancer cells was significantly correlated with overall survival in patients with diffuse-type gastric cancer (<i>p</i> = 0.041). <b><i>Conclusion:</i></b> In gastric cancer, ASPN was expressed mainly on stromal cells and partially on cancer cells. ASPN expression on stromal cells and/or cancer cells might be a useful prognostic marker in patients with diffuse-type gastric cancer.

1016 LOSS OF TGFBR2 IN DIFFUSE TYPE GASTRIC CANCER REMODELS ANGIOGENIC AND FIBROGENIC TUMOR MICROENVIRONMENT TO PROMOTE CANCER PROGRESSION.

2020 ◽  
Vol 158 (6) ◽  
pp. S-203
Author(s):  
Masahiro Hata ◽  
Yoku Hayakawa ◽  
Hiroto Kinoshita ◽  
Mayo Tsuboi ◽  
Hayato Nakagawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer

scholarly journals MiR-1284 suppresses gastric cancer progression by targeting EIF4A1

2019 ◽  
Vol Volume 12 ◽  
pp. 3965-3976 ◽  
Author(s):  
Weiyuan Wei ◽  
Wenlong Cao ◽  
Zexu Zhan ◽  
Linhai Yan ◽  
Yubo Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Gastric Cancer Progression
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