Efficient Gene Silencing in Lungs and Liver Using Imidazole-Modified Chitosan As a Nanocarrier for Small Interfering RNA

2010 ◽  
Vol 20 (3) ◽  
pp. 163-172 ◽  
Author(s):  
Bilal Ghosn ◽  
Ankur Singh ◽  
Mu Li ◽  
Alexander V. Vlassov ◽  
Chris Burnett ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Modified Chitosan ◽  
Efficient Gene ◽  
Interfering Rna

scholarly journals New Generation of Artificial MicroRNA and Synthetic Trans-Acting Small Interfering RNA Vectors for Efficient Gene Silencing in Arabidopsis

2014 ◽  
Vol 165 (1) ◽  
pp. 15-29 ◽  
Author(s):  
Alberto Carbonell ◽  
Atsushi Takeda ◽  
Noah Fahlgren ◽  
Simon C. Johnson ◽  
Josh T. Cuperus ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Artificial Microrna ◽  
Efficient Gene ◽  
New Generation ◽  
Interfering Rna

Bioreducible, Arginine-Rich Polydisulfide-Based siRNA Nanocomplex with Excellent Tumor Penetra-tion for Efficient Gene Silencing

2021 ◽  
Author(s):  
Xinyue Zhang ◽  
Kai Hong ◽  
Qingmei Sun ◽  
Yunqing Zhu ◽  
Jianzhong Du
Keyword(s):  
Rna Interference ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Gene Silencing ◽  
Small Interfering Rna ◽  
Rnai Technology ◽  
Efficient Gene ◽  
Interfering Rna

RNA interference (RNAi) technology has great potential in cancer therapy, e.g., small interfering RNA (siRNA) can be exploited to silence specific oncogenes related to tumor growth and progression. However, it...

Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology

2004 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Bentham Science Publisher Zhang J. ◽  
Bentham Science Publisher Hua Z.C.
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Knock Down ◽  
Interfering Rna

Pre-Injection of Small Interfering RNA (siRNA) Promotes c-Jun Gene Silencing and Decreases the Survival Rate of Axotomy-Injured Spinal Motoneurons in Adult Mice

2018 ◽  
Vol 65 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Ying-qin Li ◽  
Fa-huan Song ◽  
Ke Zhong ◽  
Guang-yin Yu ◽  
Prince Last Mudenda Zilundu ◽  
...  
Keyword(s):  
Survival Rate ◽  
Gene Silencing ◽  
Small Interfering Rna ◽  
Spinal Motoneurons ◽  
Adult Mice ◽  
Interfering Rna

scholarly journals Carbon Dots for Efficient Small Interfering RNA Delivery and Gene Silencing in Plants

2020 ◽  
Vol 184 (2) ◽  
pp. 647-657 ◽  
Author(s):  
Steven H. Schwartz ◽  
Bill Hendrix ◽  
Paul Hoffer ◽  
Rick A. Sanders ◽  
Wei Zheng
Keyword(s):  
Gene Silencing ◽  
Carbon Dots ◽  
Small Interfering Rna ◽  
Interfering Rna

scholarly journals Switching the intracellular pathway and enhancing the therapeutic efficacy of small interfering RNA by auroliposome

2020 ◽  
Vol 6 (30) ◽  
pp. eaba5379 ◽  
Author(s):  
Md. Nazir Hossen ◽  
Lin Wang ◽  
Harisha R. Chinthalapally ◽  
Joe D. Robertson ◽  
Kar-Ming Fung ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gold Nanoparticles ◽  
Gene Silencing ◽  
Small Interfering Rna ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Ovarian Cancer Cells ◽  
Interfering Rna

Gene silencing using small-interfering RNA (siRNA) is a viable therapeutic approach; however, the lack of effective delivery systems limits its clinical translation. Herein, we doped conventional siRNA-liposomal formulations with gold nanoparticles to create “auroliposomes,” which significantly enhanced gene silencing. We targeted MICU1, a novel glycolytic switch in ovarian cancer, and delivered MICU1-siRNA using three delivery systems—commercial transfection agents, conventional liposomes, and auroliposomes. Low-dose siRNA via transfection or conventional liposomes was ineffective for MICU1 silencing; however, in auroliposomes, the same dose gave >85% gene silencing. Efficacy was evident from both in vitro growth assays of ovarian cancer cells and in vivo tumor growth in human ovarian cell line—and patient-derived xenograft models. Incorporation of gold nanoparticles shifted intracellular uptake pathways such that liposomes avoided degradation within lysosomes. Auroliposomes were nontoxic to vital organs. Therefore, auroliposomes represent a novel siRNA delivery system with superior efficacy for multiple therapeutic applications.

Small interfering RNA delivery and gene silencing using polymeric nanocarrier systems

2005 ◽  
Vol 1 (3) ◽  
pp. 299-299
Author(s):  
K. A. Howard ◽  
X. Liu ◽  
D. Oupicky ◽  
S. Zoffmann ◽  
F. Besenbacher ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Interfering Rna ◽  
Polymeric Nanocarrier

scholarly journals Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

2009 ◽  
Vol 8 (6) ◽  
pp. 526-533 ◽  
Author(s):  
Kim A. Woodrow ◽  
Yen Cu ◽  
Carmen J. Booth ◽  
Jennifer K. Saucier-Sawyer ◽  
Monica J. Wood ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Biodegradable Polymer ◽  
Small Interfering Rna ◽  
Polymer Nanoparticles ◽  
Interfering Rna
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