Bioreducible, Arginine-Rich Polydisulfide-Based siRNA Nanocomplex with Excellent Tumor Penetra-tion for Efficient Gene Silencing

2021 ◽  
Author(s):  
Xinyue Zhang ◽  
Kai Hong ◽  
Qingmei Sun ◽  
Yunqing Zhu ◽  
Jianzhong Du
Keyword(s):  
Rna Interference ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Gene Silencing ◽  
Small Interfering Rna ◽  
Rnai Technology ◽  
Efficient Gene ◽  
Interfering Rna

RNA interference (RNAi) technology has great potential in cancer therapy, e.g., small interfering RNA (siRNA) can be exploited to silence specific oncogenes related to tumor growth and progression. However, it...

scholarly journals Small Interfering RNA- Modern Approach for Intervening Pathological Conditions

2021 ◽  
Vol 2 (2) ◽  
pp. 16-19
Author(s):  
Shazia Choudhary ◽  
Sheeba Murad ◽  
Sana Gul ◽  
Hayat Khan ◽  
Samra Khalid ◽  
...  
Keyword(s):  
Rna Interference ◽  
Small Interfering Rna ◽  
Sirna Delivery ◽  
Rnai Pathway ◽  
Modern Approach ◽  
Rna Molecules ◽  
Rnai Technology ◽  
Efficient Delivery ◽  
Biological Discovery ◽  
Interfering Rna

RNA interference (RNAi) refers to the inhibition of gene expression by small double-stranded RNA molecules. This technology can prove to be a breakthrough biological discovery of the decade as it has the potential to revolutionize the field of therapeutics. RNA interference (RNAi) through small interfering RNA (siRNA) is currently being evaluated for its efficacy to be used in therapeutics as well as prophylactic strategies. Many studies are being conducted across the globe to optimize the siRNA delivery systems (in terms of safe, stable and efficient delivery) in various disorders. There are a number of diseases such as autoimmune diseases, cancer associated pathological changes, bacterial and viral induced disorders, where RNAi pathway can be explored and RNAi technology can be used as a tool to intervene such abnormalities. This review is an effort to review latest advancements in the field of siRNA based therapy development and the pits and falls generally encountered in the use of this technology.

Efficient Gene Silencing in Lungs and Liver Using Imidazole-Modified Chitosan As a Nanocarrier for Small Interfering RNA

2010 ◽  
Vol 20 (3) ◽  
pp. 163-172 ◽  
Author(s):  
Bilal Ghosn ◽  
Ankur Singh ◽  
Mu Li ◽  
Alexander V. Vlassov ◽  
Chris Burnett ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Modified Chitosan ◽  
Efficient Gene ◽  
Interfering Rna

scholarly journals New Generation of Artificial MicroRNA and Synthetic Trans-Acting Small Interfering RNA Vectors for Efficient Gene Silencing in Arabidopsis

2014 ◽  
Vol 165 (1) ◽  
pp. 15-29 ◽  
Author(s):  
Alberto Carbonell ◽  
Atsushi Takeda ◽  
Noah Fahlgren ◽  
Simon C. Johnson ◽  
Josh T. Cuperus ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Artificial Microrna ◽  
Efficient Gene ◽  
New Generation ◽  
Interfering Rna

RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

2011 ◽  
Vol 79 (6) ◽  
pp. 953-963 ◽  
Author(s):  
Jie Wei ◽  
Jeffrey Jones ◽  
Jing Kang ◽  
Ananda Card ◽  
Michael Krimm ◽  
...  
Keyword(s):  
Rna Interference ◽  
Gene Silencing ◽  
Small Interfering Rna ◽  
Interfering Rna

scholarly journals Amphiphysin 1 Is Important for Actin Polymerization during Phagocytosis

2007 ◽  
Vol 18 (11) ◽  
pp. 4669-4680 ◽  
Author(s):  
Hiroshi Yamada ◽  
Emiko Ohashi ◽  
Tadashi Abe ◽  
Norihiro Kusumi ◽  
Shun-AI Li ◽  
...  
Keyword(s):  
Rna Interference ◽  
Sertoli Cells ◽  
Small Interfering Rna ◽  
Actin Polymerization ◽  
Actin Dynamics ◽  
Polymerization Process ◽  
Amphiphysin 1 ◽  
Phagocytic Cups ◽  
Interfering Rna ◽  
Constitutively Active

Amphiphysin 1 is involved in clathrin-mediated endocytosis. In this study, we demonstrate that amphiphysin 1 is essential for cellular phagocytosis and that it is critical for actin polymerization. Phagocytosis in Sertoli cells was induced by stimulating phosphatidylserine receptors. This stimulation led to the formation of actin-rich structures, including ruffles, phagocytic cups, and phagosomes, all of which showed an accumulation of amphiphysin 1. Knocking out amphiphysin 1 by RNA interference in the cells resulted in the reduction of ruffle formation, actin polymerization, and phagocytosis. Phagocytosis was also drastically decreased in amph 1 (−/−) Sertoli cells. In addition, phosphatidylinositol-4,5-bisphosphate–induced actin polymerization was decreased in the knockout testis cytosol. The addition of recombinant amphiphysin 1 to the cytosol restored the polymerization process. Ruffle formation in small interfering RNA-treated cells was recovered by the expression of constitutively active Rac1, suggesting that amphiphysin 1 functions upstream of the protein. These findings support that amphiphysin 1 is important in the regulation of actin dynamics and that it is required for phagocytosis.

scholarly journals A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model

2007 ◽  
Vol 122 (3) ◽  
pp. 658-663 ◽  
Author(s):  
Kentaro Iwaki ◽  
Kohei Shibata ◽  
Masayuki Ohta ◽  
Yuichi Endo ◽  
Hiroki Uchida ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Small Interfering Rna ◽  
Xenograft Model ◽  
Rna Targeting ◽  
Interfering Rna

Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology

2004 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Bentham Science Publisher Zhang J. ◽  
Bentham Science Publisher Hua Z.C.
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Knock Down ◽  
Interfering Rna

DrosophilaoncogeneGas41is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway

FEBS Journal ◽  
2014 ◽  
Vol 282 (1) ◽  
pp. 153-173 ◽  
Author(s):  
Sumit G. Gandhi ◽  
Indira Bag ◽  
Saswati Sengupta ◽  
Manika Pal-Bhadra ◽  
Utpal Bhadra
Keyword(s):  
Rna Interference ◽  
Small Interfering Rna ◽  
Interfering Rna
Sign in / Sign up

Export Citation Format

Share Document