Imaging markers for the characterization of grey and white matter changes from acute to chronic stages after experimental traumatic brain injury.

2020 ◽  
Author(s):  
Michel Sinke ◽  
Willem M. Otte ◽  
Anu E. Meerwaldt ◽  
Bart A.A. Franx ◽  
Mohamed H. Ali ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
White Matter Changes ◽  
Imaging Markers ◽  
Experimental Traumatic Brain Injury

White Matter Changes Caused by Mild Traumatic Brain Injury in Mice Evaluated Using Neurite Orientation Dispersion and Density Imaging

2020 ◽  
Vol 37 (16) ◽  
pp. 1818-1828
Author(s):  
Lisa M. Gazdzinski ◽  
Miranda Mellerup ◽  
Tong Wang ◽  
Seyed Amir Ali Adel ◽  
Jason P. Lerch ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
White Matter Changes

scholarly journals Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort

2013 ◽  
Vol 35 (1) ◽  
pp. 23-29 ◽  
Author(s):  
J. Dinkel ◽  
A. Drier ◽  
O. Khalilzadeh ◽  
V. Perlbarg ◽  
V. Czernecki ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Severe Traumatic Brain Injury ◽  
Prospective Cohort ◽  
White Matter Changes

scholarly journals Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?

2022 ◽  
Vol 11 (2) ◽  
pp. 358
Author(s):  
Francesco Latini ◽  
Markus Fahlström ◽  
Fredrik Vedung ◽  
Staffan Stensson ◽  
Elna-Marie Larsson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Diffusion Tensor ◽  
Global Analysis ◽  
Memory Performance ◽  
Regional Analysis ◽  
Long Term Memory ◽  
Post Injury ◽  
White Matter Changes

Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of post-injury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p < 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p < 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.

scholarly journals Combining Biochemical and Imaging Markers to Improve Diagnosis and Characterization of Mild Traumatic Brain Injury in the Acute Setting: Results from a Pilot Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80296 ◽  
Author(s):  
Zhifeng Kou ◽  
Ramtilak Gattu ◽  
Firas Kobeissy ◽  
Robert D. Welch ◽  
Brian J. O’Neil ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pilot Study ◽  
Mild Traumatic Brain Injury ◽  
Acute Setting ◽  
Imaging Markers
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