scholarly journals Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

2016 ◽  
Vol 33 (14) ◽  
pp. 1303-1316 ◽  
Author(s):  
Shuzhen Guo ◽  
Josephine Lok ◽  
Song Zhao ◽  
Wendy Leung ◽  
Angel T. Som ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Controlled Cortical Impact ◽  
Cortical Impact

scholarly journals Measurement of viscoelastic properties of injured mouse brain after controlled cortical impact

2020 ◽  
Vol 6 (4) ◽  
pp. 137-145
Author(s):  
Yu Chen ◽  
Suhao Qiu ◽  
Cheng Wang ◽  
Xiaowei Li ◽  
Yaohui Tang ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Viscoelastic Properties ◽  
Controlled Cortical Impact ◽  
Cortical Impact

Simulation of Mouse Brain Tissue Under Controlled Cortical Impact

2018 ◽  
Author(s):  
Haifeng Zhao ◽  
Changxin Lai ◽  
Ke Wang ◽  
Suhao Qiu ◽  
Tianyao Wang ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Mouse Brain ◽  
Impact Angle ◽  
Von Mises Stress ◽  
Fe Model ◽  
Controlled Cortical Impact ◽  
Cortical Impact ◽  
Von Mises ◽  
The Impact ◽  
The Brain

Traumatic brain injury is one of the leading causes of injury and death in both developed and developing countries. Animal models are important preclinical tools for injury level studies. In this study, a finite element (FE) model of mouse brain was constructed to investigate the biomechanical responses of brain tissue during a controlled cortical impact (CCI). Impact of the brain tissue was simulated with varying impact speeds and angles. Computational results indicated that the viscoelastic properties of the brain tissue and the impact angle could greatly influence the injury responses. Comparison with the experimental observation showed that energy based stress parameters such as the von Mises stress has the potential to be descriptive of the injury levels.

Traumatic Brain Injury-Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

1993 ◽  
Vol 61 (6) ◽  
pp. 2015-2024 ◽  
Author(s):  
Alan M. Palmer ◽  
Donald W. Marion ◽  
Michelle L. Botscheller ◽  
Pamela E. Swedlow ◽  
Scott D. Styren ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Impact Model ◽  
Controlled Cortical Impact ◽  
Cortical Impact

Acute Response of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat

2015 ◽  
Vol 57 (2) ◽  
pp. 282-303 ◽  
Author(s):  
Babru B. Samal ◽  
Cameron K. Waites ◽  
Camila Almeida-Suhett ◽  
Zheng Li ◽  
Ann M. Marini ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Controlled Cortical Impact ◽  
Acute Response ◽  
Cortical Impact

Atorvastatin reduction of intracranial hematoma volume in rats subjected to controlled cortical impact

2004 ◽  
Vol 101 (5) ◽  
pp. 822-825 ◽  
Author(s):  
Dunyue Lu ◽  
Asim Mahmood ◽  
Changsheng Qu ◽  
Anton Goussev ◽  
Mei Lu ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Functional Improvement ◽  
Intracranial Hematoma ◽  
Imaging Device ◽  
Controlled Cortical Impact ◽  
Content Type ◽  
Tissue Sections ◽  
Male Wistar Rats ◽  
Cortical Impact ◽  
Fine Print

Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects such as improving thrombogenic profile, promoting angiogenesis, and reducing inflammatory responses and has shown promise in enhancing neurological functional improvement and promoting neuroplasticity in animal models of traumatic brain injury (TBI), stroke, and intracranial hemorrhage. The authors tested the effect of atorvastatin on intracranial hematoma after TBI. Methods. Male Wistar rats were subjected to controlled cortical impact, and atorvastatin (1 mg/kg) was orally administered 1 day after TBI and daily for 7 days thereafter. Rats were killed at 1, 8, and 15 days post-TBI. The temporal profile of intraparenchymal hematoma was measured on brain tissue sections by using a MicroComputer Imaging Device and light microscopy. Conclusions. Data in this study showed that intraparenchymal and intraventricular hemorrhages are present 1 day after TBI and are absorbed at 15 days after TBI. Furthermore, atorvastatin reduces the volume of intracranial hematoma 8 days after TBI.

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