scholarly journals Long-Term In Vivo Imaging of Viscoelastic Properties of the Mouse Brain after Controlled Cortical Impact

2013 ◽  
Vol 30 (17) ◽  
pp. 1512-1520 ◽  
Author(s):  
Thomas Boulet ◽  
Matthew L. Kelso ◽  
Shadi F. Othman
Keyword(s):  
Mouse Brain ◽  
In Vivo Imaging ◽  
Viscoelastic Properties ◽  
Controlled Cortical Impact ◽  
Cortical Impact

scholarly journals Measurement of viscoelastic properties of injured mouse brain after controlled cortical impact

2020 ◽  
Vol 6 (4) ◽  
pp. 137-145
Author(s):  
Yu Chen ◽  
Suhao Qiu ◽  
Cheng Wang ◽  
Xiaowei Li ◽  
Yaohui Tang ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Viscoelastic Properties ◽  
Controlled Cortical Impact ◽  
Cortical Impact

Long-Term In Vivo Imaging of Individual Microglial Cells

2019 ◽  
pp. 177-189
Author(s):  
Angelos A. Skodras ◽  
Jasmin K. Hefendehl ◽  
Jonas J. Neher
Keyword(s):  
In Vivo Imaging ◽  
Microglial Cells

Cannabinoid effects on adenylate cyclase and phosphodiesterase activities of mouse brain

1977 ◽  
Vol 55 (4) ◽  
pp. 934-942 ◽  
Author(s):  
Thomas W. Dolby ◽  
Lewis J. Kleinsmith
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Mouse Brain ◽  
Biogenic Amine ◽  
Specific Activity ◽  
Intraperitoneal Administration ◽  
The Brain

The experiments presented in this paper examine the mechanisms underlying the ability of cannabinoids to alter the in vivo levels of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) in mouse brain. It was found that changes in cyclic AMP levels are a composite result of direct actions of cannabinoids on adenylate cyclase (EC 4.6.1.1) activity and indirect actions involving the potentiation or inhibition of biogenic amine induced activity of adenylate cyclase. Furthermore, the long-term intraperitoneal administration of 1-(−)-Δ-tetrahydrocannabinol to mice produced a form of phosphodiesterase (EC 3.1.4.17) in the brain whose activity is not stimulated by Ca2+, although its basal specific activity is similar to that of control animals. In vitro, the presence of the cannabinoids caused no significant changes in activity of brain PDE at the concentrations tested. Some correlations are presented which imply that many of the observed behavioral and physiological actions of the cannabinoids in mammalian organisms may be mediated via cyclic AMP mechanisms.

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Nature ◽  
2002 ◽  
Vol 420 (6917) ◽  
pp. 788-794 ◽  
Author(s):  
Joshua T. Trachtenberg ◽  
Brian E. Chen ◽  
Graham W. Knott ◽  
Guoping Feng ◽  
Joshua R. Sanes ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
In Vivo Imaging

scholarly journals Effects of Controlled Cortical Impact on the Mouse Brain Vasculome

2016 ◽  
Vol 33 (14) ◽  
pp. 1303-1316 ◽  
Author(s):  
Shuzhen Guo ◽  
Josephine Lok ◽  
Song Zhao ◽  
Wendy Leung ◽  
Angel T. Som ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Controlled Cortical Impact ◽  
Cortical Impact

In vivo imaging of myocardial cell death using a peptide probe and assessment of long-term heart function

2013 ◽  
Vol 172 (1) ◽  
pp. 367-373 ◽  
Author(s):  
Bodhraj Acharya ◽  
Kai Wang ◽  
In-San Kim ◽  
WoongChol Kang ◽  
Chanil Moon ◽  
...  
Keyword(s):  
Cell Death ◽  
In Vivo Imaging ◽  
Heart Function ◽  
Myocardial Cell ◽  
Peptide Probe

scholarly journals Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum

2014 ◽  
Vol 111 (1) ◽  
pp. 208-216 ◽  
Author(s):  
Naoko Nishiyama ◽  
Jeremy Colonna ◽  
Elise Shen ◽  
Jennifer Carrillo ◽  
Hiroshi Nishiyama
Keyword(s):  
In Vivo Imaging ◽  
Time Window ◽  
Time Lapse ◽  
Mammalian Brain ◽  
Cerebellar Neurons ◽  
Brain Functions ◽  
Time Lapse Imaging ◽  
Synaptic Circuitry

Synapses are continuously formed and eliminated throughout life in the mammalian brain, and emerging evidence suggests that this structural plasticity underlies experience-dependent changes of brain functions such as learning and long-term memory formation. However, it is generally difficult to understand how the rewiring of synaptic circuitry observed in vivo eventually relates to changes in animal's behavior. This is because afferent/efferent connections and local synaptic circuitries are very complicated in most brain regions, hence it is largely unclear how sensorimotor information is conveyed, integrated, and processed through a brain region that is imaged. The cerebellar cortex provides a particularly useful model to challenge this problem because of its simple and well-defined synaptic circuitry. However, owing to the technical difficulty of chronic in vivo imaging in the cerebellum, it remains unclear how cerebellar neurons dynamically change their structures over a long period of time. Here, we showed that the commonly used method for neocortical in vivo imaging was not ideal for long-term imaging of cerebellar neurons, but simple optimization of the procedure significantly improved the success rate and the maximum time window of chronic imaging. The optimized method can be used in both neonatal and adult mice and allows time-lapse imaging of cerebellar neurons for more than 5 mo in ∼80% of animals. This method allows vital observation of dynamic cellular processes such as developmental refinement of synaptic circuitry as well as long-term changes of neuronal structures in adult cerebellum under longitudinal behavioral manipulations.

scholarly journals Long-term in vivo imaging of translated RNAs for gene therapy

Gene Therapy ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 434-439 ◽  
Author(s):  
K Pinel ◽  
J Lacoste ◽  
G Plane ◽  
M Ventura ◽  
F Couillaud
Keyword(s):  
Gene Therapy ◽  
In Vivo Imaging
Sign in / Sign up

Export Citation Format

Share Document