Post-Injury Delivery of rAAV2-CNTF Combined with Short-Term Pharmacotherapy Is Neuroprotective and Promotes Extensive Axonal Regeneration after Optic Nerve Trauma

2011 ◽  
Vol 28 (12) ◽  
pp. 2475-2483 ◽  
Author(s):  
Mats Hellström ◽  
Margaret A. Pollett ◽  
Alan R. Harvey
Keyword(s):  
Optic Nerve ◽  
Axonal Regeneration ◽  
Short Term ◽  
Post Injury ◽  
Nerve Trauma

Optic Nerve Trauma with Prolonged Blindness Followed by Visual-Evoked Potential

1987 ◽  
Vol 194 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Fabian A. Abraham ◽  
Avraham Spierer ◽  
Michael Blumenthal
Keyword(s):  
Optic Nerve ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Nerve Trauma ◽  
Visual Evoked

scholarly journals Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

2016 ◽  
Vol 2 ◽  
pp. 205521731664170 ◽  
Author(s):  
Melissa M Gresle ◽  
Yaou Liu ◽  
Trevor J Kilpatrick ◽  
Dennis Kemper ◽  
Qi-Zhu Wu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axonal Regeneration ◽  
Antibody Therapy ◽  
Experimental Models ◽  
Therapeutic Effects ◽  
Axonal Loss ◽  
Nerve Crush ◽  
Acute Optic Neuritis ◽  
Injury Models

Background Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron and oligodendrocyte survival, axon regeneration, and (re)myelination. The therapeutic effects of anti-LINGO-1 antibodies on optic nerve axonal loss and regeneration have not yet been investigated. Objective In this series of studies we investigate if LINGO-1 antibodies can prevent acute inflammatory axonal loss, and promote axonal regeneration after injury in rodent optic nerves. Methods The effects of anti-LINGO-1 antibody on optic nerve axonal damage were assessed using rodent myelin oligodendrocyte glycoprotein experimental autoimmune encephalomyelitis (EAE), and its effects on axonal regeneration were assessed in optic nerve crush injury models. Results In the optic nerve, anti-LINGO-1 antibody therapy was associated with improved optic nerve parallel diffusivity measures on MRI in mice with EAE and reduced axonal loss in rat EAE. Both anti-LINGO-1 antibody therapy and the genetic deletion of LINGO-1 reduced nerve crush-induced axonal degeneration and enhanced axonal regeneration. Conclusion These data demonstrate that LINGO-1 blockade is associated with axonal protection and regeneration in the injured optic nerve.

Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve

2013 ◽  
Vol 51 ◽  
pp. 202-213 ◽  
Author(s):  
Vincent Pernet ◽  
Sandrine Joly ◽  
Deniz Dalkara ◽  
Noémie Jordi ◽  
Olivia Schwarz ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Gene Transfer ◽  
Axonal Regeneration ◽  
Long Distance

Relationship between chronic demyelination of the optic nerve and short term axonal loss

2011 ◽  
Vol 83 (3) ◽  
pp. 311-314 ◽  
Author(s):  
A Klistorner ◽  
R Garrick ◽  
M Paine ◽  
S L Graham ◽  
H Arvind ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axonal Loss ◽  
Short Term

Short term outcomes of children with abusive head trauma two years post injury: A retrospective study

2020 ◽  
Vol 13 (3) ◽  
pp. 241-253
Author(s):  
Sarah Badger ◽  
Mary-Clare Waugh ◽  
Jan Hancock ◽  
Susan Marks ◽  
Karen Oakley
Keyword(s):  
Social Skills ◽  
Head Trauma ◽  
Abusive Head Trauma ◽  
Abnormal Development ◽  
Fine Motor ◽  
Play Skills ◽  
Speech And Language ◽  
Short Term ◽  
Post Injury

PURPOSE: Abusive head trauma (AHT) can have debilitating sequelae for children who survive. A retrospective medical record review was used to describe short-term developmental outcomes of children with AHT and identify predictors of poorer outcomes. METHOD: Children with AHT who received follow up by the hospital’s rehabilitation department for 12 to 24 months post-injury were included in this review. Data for 85 children were collected on hearing, vision, gross motor, fine motor, speech and language, cognition, play, adaptive functioning, behaviour and personal-social skills. RESULTS: Global assessment found 42% of children had a good recovery, 34% had a moderate disability and 24% had a severe disability. For whom there was data, more than half had abnormal cognition, behaviour and personal-social skills, whilst more than a third had abnormal speech and language, neurological signs on last assessment, vision, play skills, and gross and fine motor skills. Factors that predicted poorer prognosis across all developmental domains included paediatric intensive care unit admission, longer length of hospital stay, breathing difficulty and lower Glasgow Coma Scale on presentation. CONCLUSION: This study highlights the substantial number of children who have abnormal development in the short-term post-AHT and assists in identifying those who require extensive long-term follow up.

scholarly journals Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse

Neuroscience ◽  
2017 ◽  
Vol 343 ◽  
pp. 372-383 ◽  
Author(s):  
Amit K. Patel ◽  
Kevin K. Park ◽  
Abigail S. Hackam
Keyword(s):  
Optic Nerve ◽  
Wnt Signaling ◽  
Nerve Injury ◽  
Axonal Regeneration ◽  
Optic Nerve Injury

Methylprednisolone exacerbates axonal loss following optic nerve trauma in rats

2002 ◽  
Vol 7 (2) ◽  
pp. 136-136
Author(s):  
KD Steinsapir ◽  
RA Goldberg ◽  
S Sinha ◽  
DA Hovda
Keyword(s):  
Optic Nerve ◽  
Axonal Loss ◽  
Nerve Trauma

scholarly journals Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture.

1980 ◽  
Vol 84 (3) ◽  
pp. 483-494 ◽  
Author(s):  
R Mirsky ◽  
J Winter ◽  
E R Abney ◽  
R M Pruss ◽  
J Gavrilovic ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Schwann Cells ◽  
Dorsal Root ◽  
Basic Protein ◽  
Intrinsic Properties ◽  
Short Term ◽  
Explant Cultures ◽  
Specific Proteins

We have used antibodies to identify Schwann cells and oligodendrocytes and to study the expression of myelin-specific glycolipids and proteins in these cells isolated from perinatal rats. Our findings suggest that only Schwann cells which have been induced to myelinate make detectable amounts of galactocerebroside (GC), sulfatide, myelin basic protein (BP), or the major peripheral myelin glycoprotein (P0). When rat Schwann cells were cultured, they stopped making detectable amounts of these myelin molecules, even when the cells were associated with neurites in short-term explant cultures of dorsal root ganglion. In contrast, oligodendrocytes in dissociated cell cultures of neonatal optic nerve, corpus callosum, or cerebellum continued to make GC, sulfatide and BP for many weeks, even in the absence of neurons. These findings suggest that while rat Schwann cells require a continuing signal from appropriate axons to make detectable amounts of myelin-specific glycolipids and proteins, oligodendrocytes do not. Schwann cells and oligodendrocytes also displayed very different morphologies in vitro which appeared to reflect their known differences in myelinating properties in vivo. Since these characteristic morphologies are maintained when Schwann cells and oligodendrocytes were grown together in mixed cultures and in the absence of neurons, we concluded that they are intrinsic properties of these two different myelin-forming cells.

scholarly journals Fish optic nerve oligodendrocytes support axonal regeneration of fish and mammalian retinal ganglion cells

Glia ◽  
1993 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Martin Bastmeyer ◽  
Mathias Bähr ◽  
Claudia A. O. Stuermer
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Axonal Regeneration ◽  
Ganglion Cells ◽  
Retinal Ganglion
Sign in / Sign up

Export Citation Format

Share Document