Associations Between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome, Insulin Resistance, and Lifestyle Habits in Healthy Japanese

2020 ◽  
Vol 18 (5) ◽  
pp. 260-266 ◽  
Author(s):  
Kengo Moriyama
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lifestyle Habits ◽  
Cholesterol Ratio

Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

2018 ◽  
Vol 10 (46) ◽  
pp. 5493-5498
Author(s):  
Zhigang Li ◽  
Xifa Lan ◽  
Xiaoxiao Jiang ◽  
Qiaoyun Wang ◽  
Zhenhe Ma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
Ft Raman Spectroscopy ◽  
Atr Spectroscopy ◽  
Ft Raman

The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis.

Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study

2020 ◽  
Vol 33 (6) ◽  
pp. 777-784
Author(s):  
Nazlı Nur Aslan Çin ◽  
Hülya Yardımcı ◽  
Nevra Koç ◽  
Seyit Ahmet Uçaktürk ◽  
Mehtap Akçil Ok
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Obese Adolescents ◽  
Positive Correlation ◽  
Tyg Index

AbstractObjectivesMetabolic syndrome (MS) is a fatal endocrinopathy that begins with insulin resistance (IR) and causes abdominal obesity, glucose intolerance, or systemic disorders. This study was aimed to determine the cut-off values for the triglyceride (TG)/high-density lipoprotein cholesterol (TG/HDL-C) ratio, the TG glucose (TyG) index and homeostasis model assessment (HOMA-IR) for the diagnosis of MS in obese adolescents, and to compare which of the three indexes would offer a more accurate approach to diagnosis.MethodsThe study population comprised 1,171 obese adolescents (639 females and 532 males aged 10–16 years, Body Mass Index (BMI)>=95th percentile). Indirect measures of IR screening for MS were the TG/HDL ratio, TyG index, and HOMA-IR. The cut-off values of the TG/HDL ratio, TyG index, and HOMA-IR were obtained from receiver operation characteristic (ROC) curves.ResultsHOMA-IR had a significant positive correlation with the TyG index (r=0.352, p<0.001) and TG/HDL-C (r=0.291, p<.001). The TyG index and TG/HDL-C showed a strong positive correlation (r=0.901, p<0.001). The TG/HDL-C ratio showed a larger ROC Area under Curve (AUC=0.849) than HOMA-IR index (AUC=0.689), but as a predictor similar to TyG index (AUC=0.833) when screening for MS. The cut-off values for MS were as follows: TG/HDL-C ratio>2.16 (sensitivity: 88.8%; specificity: 49.7%), TyG index>8.50 (sensitivity: 85.6%; specificity: 57.0%) and HOMA-IR>2.52 (sensitivity: 83.2%; specificity: 40.4%).ConclusionsBoth the TyG index and TG/HDL-C ratio are better markers than HOMA-IR to determine the risk of metabolic syndrome according to IDF criteria. Besides, the TyG index and TG/HDL-C ratio have similar differentiating powers to determine this risk in obese Turkish adolescents.

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