Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

2018 ◽  
Vol 10 (46) ◽  
pp. 5493-5498
Author(s):  
Zhigang Li ◽  
Xifa Lan ◽  
Xiaoxiao Jiang ◽  
Qiaoyun Wang ◽  
Zhenhe Ma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
Ft Raman Spectroscopy ◽  
Atr Spectroscopy ◽  
Ft Raman

The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis.

scholarly journals Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Health ◽  
2013 ◽  
Vol 05 (03) ◽  
pp. 481-485 ◽  
Author(s):  
Antônio C. Oliveira ◽  
Ana M. Oliveira ◽  
Nelson Oliveira ◽  
Atila Oliveira ◽  
Marcele Almeida ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio

scholarly journals Association of triglycerides/high density lipoprotein cholesterol ratio with insulin resistance in polycystic ovary syndrome

2018 ◽  
Vol 6 (12) ◽  
pp. 4028
Author(s):  
Sreenivasulu Karli ◽  
Kiranmayi V. S. ◽  
Rajendra Prasad Namburi ◽  
Aparna Rajeshwar Rao Bitla ◽  
Alok Sachan
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Ovary Syndrome ◽  
Cholesterol Ratio

Background: Insulin resistance (IR) is frequently observed in women with polycystic ovary syndrome (PCOS). Recent studies advocated that triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) can be used as a simple clinical indicator of IR. Hence, the present study was performed to investigate the use of TG/HDL-C and its association with IR in PCOS.Methods: Forty-one patients with PCOS and 40 healthy age matched women were randomly enrolled. Demographic and clinical characteristics were obtained. Insulin resistance was defined by the homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI).Results: In PCOS group, the insulin, HOMA-IR and TG/HDL-C ratio were significantly higher (p=0.001) than controls while, QUICKI was lower (p=0.001). Insulin, HOMA-IR were positively correlated with TG/HDL-C (ρ=0.303, p=0.006 and ρ=0.312, p=0.005 respectively) while, QUICKI was negatively correlated (ρ=-0.698, p=0.001). In receiver operating characteristic (ROC) analysis, area under the curve (AUC) for model based on QUICKI levels was better 0.898 (95% CI: 0.811-0.955, p=0.001) than HOMA-IR 0.636 (95% CI: 0.522-0.740, p=0.03). A cut-off value 3.23 for TG/HDL-C is proposed from the model based on QUICKI with best combination of sensitivity 83.3% and specificity 86.7%.Conclusions: Results of present study support that TG/HDL-C ratio may be a simple indicator of IR in PCOS patients which helps clinicians to identify IR in small centers, where the assays for insulin measurement are not available.

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