Potential of Nonoral α-Lipoic Acid Aqueous Formulations to Reduce Ocular Microvascular Complications in a Streptozotocin-Induced Diabetic Rat Model

2013 ◽  
Vol 29 (8) ◽  
pp. 738-745 ◽  
Author(s):  
Chen-Ling Chen ◽  
Wen-Sheng Cheng ◽  
Jiin-Long Chen ◽  
Chiao-Hsi Chiang
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Microvascular Complications ◽  
Diabetic Rat ◽  
Diabetic Rat Model

The Effect of α-Lipoic Acid on Proteinuria and Renal TGFβ Expression in Obese Type 2 Diabetic Rat Model

2008 ◽  
Vol 32 (1) ◽  
pp. 21
Author(s):  
Seok Woo Kang ◽  
Seong Jin Lee ◽  
Dong-Sun Kim ◽  
Tae Wha Kim
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

2012 ◽  
Vol 35 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Serap Cilaker Mıcılı ◽  
Bekir Uğur Ergur ◽  
Candan Ozoğul ◽  
Sülen Sarıoğlu ◽  
H. Alper Bağrıyanık ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Experimentally Induced

A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

2020 ◽  
Vol 95 (4) ◽  
pp. 305-316
Author(s):  
Elif Kayhan Kuştepe ◽  
Leyla Bahar ◽  
Emrah Zayman ◽  
Nehir Sucu ◽  
Semir Gül ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Microscopic Investigation ◽  
Diabetic Rat ◽  
Diabetic Rat Model

Exploration of the Effect and Mechanism of ShenQi Compound in a Spontaneous Diabetic Rat Model

2019 ◽  
Vol 19 (5) ◽  
pp. 622-631 ◽  
Author(s):  
Ya Liu ◽  
Jian Kang ◽  
Hong Gao ◽  
Xiyu Zhang ◽  
Jun Chao ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Signaling Pathway ◽  
Rat Model ◽  
Mtor Signaling ◽  
Diabetic Rat ◽  
Gene Microarray ◽  
Mtor Signaling Pathway ◽  
Glucose Fluctuation ◽  
Blood Glucose Fluctuation ◽  
Diabetic Rat Model

Background: Type 2 Diabetes Mellitus (T2DM) is a world-wide metabolic disease with no cure from drugs and treatment. In China, The Traditional Chinese Medicine (TCM) herbal formulations have been used to treat T2DM for centuries. Methods: In this study, we proposed a formula called ShenQi Compound (SQC), which has been used in clinical therapeutics in China for several years. We evaluated the effect of SQC in a spontaneous diabetic rat model (GK rats) by detecting a series of blood indicators and performing histological observations. Meanwhile, the gene microarray and RT-qPCR experiments were used to explore the molecular mechanism of SQC treatment. In addition, western medicine, sitagliptin was employed as a comparison. Results: The results indicated that SQC and sitagliptin could effectively improve the serum lipid (blood Total Cholesterol (TC) and blood Triglycerides (TG)), hormone levels (serum insulin (INS), Glucagon (GC) and Glucagon-Like Peptide-1 (GLP-1)), alleviated the inflammatory response (hypersensitive C-Reactive Protein (hsCRP)), blood glucose fluctuation (Mean Blood Glucose (MBG), standard deviation of blood glucose (SDBG) and Largest Amplitude of plasma Glucose Excursions (LAGE)), pancreatic tissue damage and vascular injury for T2DM. Compared with sitagliptin, SQC achieved a better effect on blood glucose fluctuation (p<0.01). Meanwhile, the gene microarray and RT-qPCR experiments indicated that SQC and sitagliptin may improve the T2DM through affecting the biological functions related to apoptosis and circadian rhythm. Moreover, SQC might be able to influence the mTOR signaling pathway by regulating Pik3r1, Ddit4 expression. Conclusion: All these results indicate that SQC is an effective therapeutic drug on T2DM. Notably, SQC presents an obvious blood glucose fluctuation-preventing ability, which might be derived from the regulation of the mTOR signaling pathway.

scholarly journals Jinmaitong decreases sciatic nerve DNA oxidative damage and apoptosis in a streptozotocin-induced diabetic rat model

2015 ◽  
Vol 10 (2) ◽  
pp. 778-786 ◽  
Author(s):  
DE-HAI YIN ◽  
XIAO-CHUN LIANG ◽  
LI ZHAO ◽  
HONG ZHANG ◽  
QING SUN ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Oxidative Damage ◽  
Rat Model ◽  
Diabetic Rat ◽  
Dna Oxidative Damage ◽  
Diabetic Rat Model

scholarly journals COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

2013 ◽  
Vol 28 (5) ◽  
pp. 725 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Hyun-Suk Lee ◽  
Kyuyoun Ahn ◽  
Kwangsung Park
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic ◽  
Angiopoietin 1

Effect ofCostus spiralis(Jacq.)RoscoeLeaves, Methanolic Extract and Guaijaverin on Blood Glucose and Lipid Levels in a Type II Diabetic Rat Model

2019 ◽  
Vol 16 (1) ◽  
pp. e1800365
Author(s):  
Regiane C. Duarte ◽  
Silvia H. Taleb-Contini ◽  
Paulo S. Pereira ◽  
Camila F. Oliveira ◽  
Carlos Eduardo S. Miranda ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Rat Model ◽  
Methanolic Extract ◽  
Diabetic Rat ◽  
Type Ii ◽  
Lipid Levels ◽  
Diabetic Rat Model
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