Adverse Reaction in Patients with Drug Allergy History After Simultaneous Intravenous Fundus Fluorescein Angiography and Indocyanine Green Angiography

2012 ◽  
Vol 28 (4) ◽  
pp. 410-413 ◽  
Author(s):  
Zhaoan Su ◽  
Panpan Ye ◽  
Yan Teng ◽  
Lixia Zhang ◽  
Xiaohong Shu

In Behcet's disease, the anterior and posterior segments of the eye may be affected separately or together. Fundus fluorescein angiography should be performed in addition to ophthalmoscopic examination for early diagnosis and treatment of ocular involvement. Fundus fluorescein angiography (FFA) is the gold standard for the evaluation of the retinal vascular system and pathologies. Fundus fluorescein angiography is more sensitive than fundus examination in the detection of vasculitis, and angiographic involvement is always more common than clinical involvement. Fluorescein angiography may reveal leakage from retinal veins in eyes whose visual impression is not affected and the fundus examination is normal. The absence of vascular leakage with fluorescein angiography indicates that the disease is in a completely inactive period. Because of the development of blindness due to posterior segment involvement, early detection of the disease with fundus angiography and the initiation of the treatment is successful in terms of visual prognosis. It has an important place in terms of early activation of patients with FFA in the early diagnosis of eye involvement and follow-up of the disease and treatment. Wide-field imaging angiography imaging of the retinal periphery revealed the importance of lesions in retinal periphery and peripheral areas invisible by standard angiography. The use of indocyanine green angiography in Behcet uveitis is limited.


The term of pachychoroid spectrum diseases is used to identify a group of diseases that are characterized by increase of choroidal thickness. The increase of choroidal thickness is caused by dilated vascular vessels in Haller’s layer and accompanied by thinning in the choriocapillaris and Sattler’s layer. The presence of characteristic morphological changes including structural and functional choroidal changes is the key pathophysiological basis for the identification of pachychoroid diseases. The spectrum of pachychoroid disease consists of different clinical manifestations that can progress from one to another. Multimodal imaging methods are used in the diagnosis, treatment, and follow-up of these diseases. In this review, color fundus photographs, fundus fluorescein angiography, and indocyanine green angiography characteristics of pachychoroid diseases are discussed.


2021 ◽  
pp. 112067212110640
Author(s):  
Francesca Amoroso ◽  
Alexandre Pedinielli ◽  
Salomon Yves Cohen ◽  
Camille Jung ◽  
Jay Chhablani ◽  
...  

Purpose There is no widely accepted treatment for persistent/chronic central serous chorioretinopathy. The present study aimed to evaluate the efficacy, safety, and factors associated to treatment response to navigated micropulse laser in chorioretinopathy. Methods Retrospective observational case series including consecutive patients presenting with symptomatic persistent and chronic chorioretinopathy. All patients were treated with 5% navigated micropulse laser with the Navilas system (Navilas®, OD-OS GmBH, Teltwo, Germany), by overlying fluorescein angiography, indocyanine green angiography and/or spectral domain-optical coherence tomography images of visible leaking points and/or choroidal hyperpermeability/subretinal fluid to plan the laser treatment. Results Thirty-nine eyes of 36 consecutive patients (29 men and 7 women, with a mean age of 51.87 years) were included. Logarithm of the minimum angle of resolution (LogMar) best-corrected visual acuity increased from 0.39 ± 0.24 at baseline to 0.24 ± 0.22 at 3 months ( p < 0.0001) and to 0.20 ± 0.07 at 6 months ( p < 0.0001). Subretinal fluid decreased from 166.82 ± 111.11 micron at baseline to 52.33 ± 78.97 micron ( p < 0.0001) at 3 months and 34.12 ± 67.56 micron at 6 months ( p < 0.0001). The presence of a hot spot on fluorescein angiography and a focal choroidal hyperpermeability on indocyanine green angiography, but not the duration of symptoms correlated significantly with the resolution of subretinal fluid at month 3 ( p = 0.023 and p  = 0.001). Conclusion Navigated micropulse laser laser treatment was found to be effective and safe for the treatment of chorioretinopathy, with significant improvement in visual and anatomical outcomes, unaccompanied by any adverse event at 3 and 6 months follow-up. Factors associated to subretinal fluid resolution may allow a better selection of likely responders to navigated micropulse laser treatment.


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