Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts

2019 ◽  
Vol 22 (8) ◽  
pp. 841-850
Author(s):  
Sun-Il Choi ◽  
Jong Seok Lee ◽  
Sarah Lee ◽  
Bong-Yeon Cho ◽  
Seung-Hyun Choi ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Protective Effects ◽  
Human Dermal Fibroblasts

scholarly journals (−)-Loliolide Isolated from Sargassum horneri Abate UVB-Induced Oxidative Damage in Human Dermal Fibroblasts and Subside ECM Degradation

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 435
Author(s):  
Ilekuttige Priyan Shanura Fernando ◽  
Soo-Jin Heo ◽  
Mawalle Kankanamge Hasitha Madhawa Dias ◽  
Dissanayaka Mudiyanselage Dinesh Madusanka ◽  
Eui-Jeong Han ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Sargassum Horneri ◽  
Mitogen Activated Protein Kinase ◽  
Ros Generation ◽  
Protective Effects ◽  
Human Dermal Fibroblasts ◽  
Mitogen Activated Protein ◽  
Uvb Exposure

Ultraviolet (UV) B exposure is a prominent cause of skin aging and a contemporary subject of interest. The effects are progressing through the generation of reactive oxygen species (ROS) that alter cell signaling pathways related to inflammatory responses. The present study evaluates the protective effects of (7aR)-6-hydroxy-4,4,7a-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (HTT) isolated from the edible brown algae Sargassum horneri against UVB protective effects in human dermal fibroblasts (HDFs). HTT treatment dose-dependently suppressed intracellular ROS generation in HDFs with an IC50 of 62.43 ± 3.22 µM. HTT abated UVB-induced mitochondrial hyperpolarization and apoptotic body formation. Furthermore, UVB-induced activation of key nuclear factor (NF)-κB and mitogen-activated protein kinase signaling proteins were suppressed in HTT treated cells while downregulating pro-inflammatory cytokines (interleukin-1β, 6, 8, 33 and tumor necrosis factor-α). Moreover, HTT treatment downregulated matrix metalloproteinase1, 2, 3, 8, 9 and 13 that was further confirmed by the inhibition of collagenase and elastase activity. The evidence implies that HTT delivers protective effects against premature skin aging caused by UVB exposure via suppressing inflammatory responses and degradation of extracellular matrix (ECM) components. Extensive research in this regard will raise perspectives for using HTT as an ingredient in UV protective ointments.

The Protective Effects of Fucosterol Against Skin Damage in UVB-Irradiated Human Dermal Fibroblasts

2013 ◽  
Vol 16 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Eunson Hwang ◽  
Sang-Yong Park ◽  
Zheng-wang Sun ◽  
Heon-Sub Shin ◽  
Don-Gil Lee ◽  
...  
Keyword(s):  
Dermal Fibroblasts ◽  
Protective Effects ◽  
Human Dermal Fibroblasts ◽  
Skin Damage

Hydrogen peroxide enhanced Ca2+-activated BK currents and promoted cell injury in human dermal fibroblasts

Life Sciences ◽  
2012 ◽  
Vol 90 (11-12) ◽  
pp. 424-431 ◽  
Author(s):  
Bing Feng ◽  
Wen-Lei Ye ◽  
Lai-ji Ma ◽  
Yun Fang ◽  
Yan-Ai Mei ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Injury ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

Tissue-protective effects of French maritime pine bark (Pycnogenol) on glutamate-induced cytotoxicity in adult human dermal fibroblasts

2017 ◽  
Vol 280 ◽  
pp. S159
Author(s):  
Çiğdem Sevim ◽  
Elif Doğan ◽  
Ali Taghizadehghalehjoughi ◽  
Semin Gedikli ◽  
Mustafa Özkaraca ◽  
...  
Keyword(s):  
Dermal Fibroblasts ◽  
Maritime Pine ◽  
Pine Bark ◽  
Protective Effects ◽  
Human Dermal Fibroblasts ◽  
Adult Human
Sign in / Sign up

Export Citation Format

Share Document