Neuroprotective Effect of Halophyte Salicornia herbacea L. Is Mediated by Activation of Heme Oxygenase-1 in Mouse Hippocampal HT22 Cells

2017 ◽  
Vol 20 (2) ◽  
pp. 140-151 ◽  
Author(s):  
Min Sun Kim ◽  
Ji Yeon Seo ◽  
Jisun Oh ◽  
Yu Kyung Jang ◽  
Choong Hwan Lee ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Heme Oxygenase 1 ◽  
Ht22 Cells ◽  
Salicornia Herbacea

scholarly journals Taraxacum coreanum protects against glutamate-induced neurotoxicity through heme oxygenase-1 expression in mouse hippocampal HT22 cells

2017 ◽  
Vol 15 (4) ◽  
pp. 2347-2352 ◽  
Author(s):  
Chi-Su Yoon ◽  
Wonmin Ko ◽  
Dong-Sung Lee ◽  
Dong-Cheol Kim ◽  
Jongsu Kim ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Ht22 Cells ◽  
Taraxacum Coreanum

scholarly journals Neuroinflammation associates with antioxidant heme oxygenase-1 response throughout the brain in persons living with HIV

2020 ◽  
Vol 26 (6) ◽  
pp. 846-862
Author(s):  
Analise L. Gruenewald ◽  
Yoelvis Garcia-Mesa ◽  
Alexander J Gill ◽  
Rolando Garza ◽  
Benjamin B. Gelman ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Expression Patterns ◽  
Distinct Pattern ◽  
Heme Oxygenase 1 ◽  
Type I ◽  
Persons Living With Hiv ◽  
Living With Hiv ◽  
Lower Expression ◽  
Hiv Negative

AbstractPrevious studies showed that persons living with HIV (PLWH) demonstrate higher brain prefrontal cortex neuroinflammation and immunoproteasome expression compared to HIV-negative individuals; these associate positively with HIV levels. Lower expression of the antioxidant enzyme heme oxygenase 1 (HO-1) was observed in PLWH with HIV-associated neurocognitive impairment (HIV-NCI) compared to neurocognitively normal PLWH. We hypothesized that similar expression patterns occur throughout cortical, subcortical, and brainstem regions in PLWH, and that neuroinflammation and immunoproteasome expression associate with lower expression of neuronal markers. We analyzed autopsied brains (15 regions) from 9 PLWH without HIV-NCI and 7 matched HIV-negative individuals. Using Western blot and RT-qPCR, we quantified synaptic, inflammatory, immunoproteasome, endothelial, and antioxidant biomarkers, including HO-1 and its isoform heme oxygenase 2 (HO-2). In these PLWH without HIV-NCI, we observed higher expression of neuroinflammatory, endothelial, and immunoproteasome markers in multiple cortical and subcortical regions compared to HIV-negative individuals, suggesting a global brain inflammatory response to HIV. Several regions, including posterior cingulate cortex, globus pallidus, and cerebellum, showed a distinct pattern of higher type I interferon (IFN)-stimulated gene and immunoproteasome expression. PLWH without HIV-NCI also had (i) stable or higher HO-1 expression and positive associations between (ii) HO-1 and HIV levels (CSF, plasma) and (iii) HO-1 expression and neuroinflammation, in multiple cortical, subcortical, and brainstem regions. We observed no differences in synaptic marker expression, suggesting little, if any, associated neuronal injury. We speculate that this may reflect a neuroprotective effect of a concurrent HO-1 antioxidant response despite global neuroinflammation, which will require further investigation.

Shogaol but not gingerol has a neuroprotective effect on hemorrhagic brain injury: Contribution of the α, β-unsaturated carbonyl to heme oxygenase-1 expression

2019 ◽  
Vol 842 ◽  
pp. 33-39 ◽  
Author(s):  
Masatoshi Ohnishi ◽  
Mayu Ohshita ◽  
Hideaki Tamaki ◽  
Yumi Marutani ◽  
Yuta Nakayama ◽  
...  
Keyword(s):  
Brain Injury ◽  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Heme Oxygenase 1

scholarly journals The herbal extract KCHO-1 exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation

2016 ◽  
Vol 13 (6) ◽  
pp. 4911-4919 ◽  
Author(s):  
DONG-SUNG LEE ◽  
WONMIN KO ◽  
BONG-KEUN SONG ◽  
ILHONG SON ◽  
DONG-WOUNG KIM ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Herbal Extract ◽  
Heme Oxygenase 1

The neuroprotective effect of heme oxygenase (HO) on oxidative stress in HO-1 siRNA-transfected HT22 cells

2006 ◽  
Vol 1108 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Asuka Kaizaki ◽  
Sachiko Tanaka ◽  
Kumiko Ishige ◽  
Satoshi Numazawa ◽  
Takemi Yoshida
Keyword(s):  
Oxidative Stress ◽  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Ht22 Cells

3.226 NEUROPROTECTIVE EFFECT OF DIPEPTIDE ANALOGUE OF BDNF - GSB-106 IN VITRO AND ITS INFLUENCE ON THE SYNTHESIS OF HEME OXYGENASE-1

2012 ◽  
Vol 18 ◽  
pp. S209-S210
Author(s):  
I.O. Logvinov ◽  
T.A. Antipova ◽  
A.V. Tarasiuk ◽  
T. Gudasheva ◽  
S. Seredenin
Keyword(s):  
Heme Oxygenase ◽  
Neuroprotective Effect ◽  
Heme Oxygenase 1

scholarly journals Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities ofViola patriniiin Murine Hippocampal and Microglia Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Bin Li ◽  
Dong-Sung Lee ◽  
Hyun-Gyu Choi ◽  
Kyoung-Su Kim ◽  
Gil-Saeng Jeong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heme Oxygenase ◽  
Therapeutic Potential ◽  
Reactive Oxygen Species Generation ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Ht22 Cells ◽  
Proinflammatory Mediators ◽  
Bv2 Cells ◽  
Anti Inflammatory

A number of diseases that lead to injury of the central nervous system are caused by oxidative stress and inflammation in the brain. In this study, NNMBS275, consisting of the ethanol extract ofViola patrinii, showed potent antioxidative and anti-inflammatory activity in murine hippocampal HT22 cells and BV2 microglia. NNMBS275 increased cellular resistance to oxidative injury caused by glutamate-induced neurotoxicity and reactive oxygen species generation in HT22 cells. In addition, the anti-inflammatory effects of NNMBS275 were demonstrated by the suppression of proinflammatory mediators, including proinflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-αand interleukin-1β). Furthermore, we found that the neuroprotective and anti-inflammatory effects of NNMBS275 were linked to the upregulation of nuclear transcription factor-E2-related factor 2-dependent expression of heme oxygenase-1 in HT22 and BV2 cells. These results suggest that NNMBS275 possesses therapeutic potential against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation.

Neuroprotective Effects of Kinetin Against Glutamate-Induced Oxidative Cytotoxicity in HT22 Cells: Involvement of Nrf2 and Heme Oxygenase-1

2017 ◽  
Vol 33 (4) ◽  
pp. 725-737 ◽  
Author(s):  
Yunpeng Wei ◽  
Dan Liu ◽  
Yin Zheng ◽  
Chaoshuang Hao ◽  
Honglian Li ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Neuroprotective Effects ◽  
Ht22 Cells
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