Sweet Dream Liquid Chinese Medicine Ameliorates Learning and Memory Deficit in a Rat Model of Paradoxical Sleep Deprivation through the ERK/CREB Signaling Pathway

2016 ◽  
Vol 19 (5) ◽  
pp. 472-480 ◽  
Author(s):  
Xinyun Su ◽  
Chunhua Wang ◽  
Xiuhua Wang ◽  
Fang Han ◽  
Changjun Lv ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Sleep Deprivation ◽  
Signaling Pathway ◽  
Learning And Memory ◽  
Rat Model ◽  
Paradoxical Sleep ◽  
Memory Deficit ◽  
Paradoxical Sleep Deprivation ◽  
Learning And Memory Deficit

Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation

2013 ◽  
Vol 16 (4) ◽  
pp. 280-287 ◽  
Author(s):  
Yuan Hu ◽  
Ming Liu ◽  
Ping Liu ◽  
Juan-Juan Yan ◽  
Ming-Yue Liu ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Learning And Memory ◽  
Rat Model ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation

EFFECT OF SLEEP DEPRIVATION ON REMINISCENCE AND APPREHENSION BEHAVIOR IN WISTAR ALBINO RATS

2019 ◽  
pp. 196-201
Author(s):  
KEERTHI PRIYA CS ◽  
MALATHI S ◽  
RAVINDRAN RAJAN
Keyword(s):  
Sleep Deprivation ◽  
Learning And Memory ◽  
Field Test ◽  
Memory Impairment ◽  
Radial Maze ◽  
Open Field Test ◽  
Paradoxical Sleep ◽  
Albino Rats ◽  
Paradoxical Sleep Deprivation ◽  
Wistar Albino Rats

Objective: The aim of the present study is to investigate the effect of paradoxical sleep deprivation (SD) on learning and memory impairment and anxiety-like behavior in female Wistar albino rats. Methods: Eight-arm radial maze, open-field test, and light and dark test were used to assess the animals learning and memory and anxiety-like behavior. Results: SD associated with weaker learning and memory and increased anxiety- and depressive-like behavior in animals. Conclusion: Animals were exposed to SD showed learning and memory impairment and also exhibited increased anxiety- and depressive-like behavior when compared to control animals.

scholarly journals Effects of Non-Spatial Pre-Training on Learning and Memory Impairment Detection in the Morris Water Maze

2016 ◽  
Vol 15 (2) ◽  
pp. 169-177
Author(s):  
Phanit KOOMHIN ◽  
Apsorn SATTAYAKHOM ◽  
Sarawoot PALIPOCH ◽  
Chuchard PUNSAWAD ◽  
Sompol TAPECHUM
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Rat Model ◽  
Water Maze ◽  
Memory Impairment ◽  
Memory Deficit ◽  
Learning Ability ◽  
Vessel Occlusion ◽  
Training Strategy ◽  
Learning And Memory Deficit

One of the most popular learning and memory tests is the Morris water maze. The Morris water maze is a circular pool filled with water with a hidden platform under the water surface. The test is appropriate for rodents, especially rats and mice. The testing protocol comprises 2 parts that evaluate learning ability and memory retention. When animals are placed in the pool, they experience stress, which is the driving force for discovery of a strategy to leave the water. In the experiment, animals use environmental cues to find the location of the hidden platform in the pool. After consecutive training days, animals can more quickly locate the hidden platform. The last day of the task involves a memory test without the platform. It shows a limitation of the test in mild learning and memory deficit models such as 2-vessel occlusion. Differences between the normal and memory impairment models are expressed only in a narrow range. So, we tried to modify the original protocol for mild learning and memory impairment models. We used an albino rat strain for the experiment. A pre-training strategy of 3 days of swimming in the pool with a visible platform prior to the ordinary task was used. The results suggest that this pre-training strategy improved learning and memory in the rat model. When compared to normal rats and 2-vessel occlusion rats (a rat model for vascular dementia), those that participated in the pre-training strategy showed an increase in the percent difference of area under the curve for learning trials. In conclusion, the pre-training strategy increases ability to discriminate learning and memory impairment in the rat model, especially for the mild learning and memory deficit models.

Development of learning and memory in mice after brief paradoxical sleep deprivation

1979 ◽  
Vol 22 (5) ◽  
pp. 971-978 ◽  
Author(s):  
Priyattam Shiromani ◽  
Baruch M. Gutwein ◽  
William Fishbein
Keyword(s):  
Sleep Deprivation ◽  
Learning And Memory ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation

scholarly journals SLEEP DEPRIVATION INTERFERES WITH JAK/STAT SIGNALING PATHWAY AND MYOGENESIS IN MASSETER MUSCLE OF RATS

2021 ◽  
Author(s):  
Marina Gomes Galvani ◽  
Hanna Karen Moreira Antunes ◽  
Marcos Monico-Neto ◽  
Veronica Quispe Yujra ◽  
Carla Maximo Prado ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Signaling Pathway ◽  
Masseter Muscle ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Cellular Density ◽  
Stat Signaling ◽  
Male Wistar Rats ◽  
Profile Area

jectives. This study evaluated the JAK/STAT signaling pathway and myogenesis on masseter muscle after sleep deprivation as well as to investigate the role of stress in this scenario. Subjetcts and Methods. A total of 18 male Wistar rats were distributed into the following groups: Control (CTRL; n=6): animals were not submitted to any procedures; Sleep Deprivation and Vehicle (PSD+V; n=6): animals were subjected to Paradoxical Sleep Deprivation for 96h and (PSD+MET; n=6): animals were subjected to Paradoxical Sleep Deprivation for 96h with administration of metyrapone. Paradoxal Sleep deprivation was performed by the Modified Multiple Platforms Method. Histopatological analysis, histomorphmetry and immunohistochemistry were performed. Results and Conclusion. The results showed the presence of inflammatory infiltrate in the PSD+V and PSD+MET groups and atrophy. Histomorphometry showed that Cellular Profile Area decreased while Cellular Density increased in both experimental groups. Expression of p-STAT 3, MyoD and MyoG increased in PSD+V group, while the PSD+MET group increased expression of IL-6 and p-STAT 3. Our results are consistent with notion that sleep deprivation induced inflammatory response and atrophy in masseter muscle of rats.

scholarly journals Aerobic exercise attenuates inhibitory avoidance memory deficit induced by paradoxical sleep deprivation in rats

2013 ◽  
Vol 1529 ◽  
pp. 66-73 ◽  
Author(s):  
Jansen Fernandes ◽  
Luiz Guilherme Zaccaro Baliego ◽  
Luiz Fernando Peixinho-Pena ◽  
Alexandre Aparecido de Almeida ◽  
Daniel Paulino Venancio ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Aerobic Exercise ◽  
Paradoxical Sleep ◽  
Inhibitory Avoidance ◽  
Memory Deficit ◽  
Paradoxical Sleep Deprivation ◽  
Avoidance Memory
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