Parboiled Germinated Brown Rice Protects Against CCl4-Induced Oxidative Stress and Liver Injury in Rats

2016 ◽  
Vol 19 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Kansuda Wunjuntuk ◽  
Aikkarach Kettawan ◽  
Somsri Charoenkiatkul ◽  
Thanaporn Rungruang
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Brown Rice ◽  
Germinated Brown Rice

scholarly journals Antioxidative Effects of Germinated Brown Rice-Derived Extracts on H2O2-Induced Oxidative Stress in HepG2 Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Nur Diyana Md Zamri ◽  
Mustapha Umar Imam ◽  
Siti Aisyah Abd Ghafar ◽  
Maznah Ismail
Keyword(s):  
Oxidative Stress ◽  
P38 Mapk ◽  
Hepg2 Cells ◽  
Culture Media ◽  
Antioxidant Properties ◽  
Brown Rice ◽  
Thiobarbituric Acid ◽  
Germinated Brown Rice ◽  
Antioxidant Genes ◽  
Transcriptional Changes

The antioxidant properties of germinated brown rice (GBR) are likely mediated by multiple bioactives. To test this hypothesis, HepG2 cells pretreated with GBR extracts, rich in acylated steryl glycoside (ASG), gamma amino butyric acid GABA), phenolics or oryzanol, were incubated with hydrogen peroxide (H2O2) and their hydroxyl radical (OH•) scavenging capacities and thiobarbituric acid-reactive substances (TBARS) generation were evaluated. Results showed that GBR-extracts increased OH•scavenging activities in both cell-free medium and posttreatment culture media, suggesting that the extracts were both direct- and indirect-acting against OH•. The levels of TBARS in the culture medium after treatment were also reduced by all the extracts. In addition, H2O2produced transcriptional changes in p53, JNK, p38 MAPK, AKT, BAX, and CDK4 that were inclined towards apoptosis, while GBR-extracts showed some transcriptional changes (upregulation of BAX and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, AKT, JNK, and p38 MAPK) suggested that GBR-extracts favored survival of the HepG2 cells. Our findings show that GBR bioactive-rich extracts reduce oxidative stress through improvement in antioxidant capacity, partly mediated through transcriptional regulation of antioxidant and prosurvival genes.

scholarly journals Germinated brown rice regulates brain oxidative stress, inflammation and acetylcholinesterase level: implication in neurodegenerative diseases

2016 ◽  
Vol 10 ◽  
Author(s):  
Azmi Nur Hanisah ◽  
Ismail Maznah ◽  
Ismail Norsharina ◽  
Mohammed Alitheen Noorjahan Banu ◽  
Abdullah Maizaton Atmadini
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Diseases ◽  
Brown Rice ◽  
Germinated Brown Rice ◽  
Brain Oxidative Stress

scholarly journals IGF-1 Induction by Acylated Steryl β-Glucosides Found in a Pre-Germinated Brown Rice Diet Reduces Oxidative Stress in Streptozotocin-Induced Diabetes

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28693 ◽  
Author(s):  
Seigo Usuki ◽  
Ying-Ying Tsai ◽  
Keiko Morikawa ◽  
Shota Nonaka ◽  
Yasuhide Okuhara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Brown Rice ◽  
Germinated Brown Rice ◽  
Streptozotocin Induced Diabetes ◽  
Rice Diet

Physiochemical Properties of Germinated Brown Rice

2012 ◽  
Vol 41 (7) ◽  
pp. 963-969 ◽  
Author(s):  
Sea-Kwan Oh ◽  
Jeong-Heui Lee ◽  
Mi-Ra Yoon ◽  
Dae-Jung Kim ◽  
Dong-Hyen Lee ◽  
...  
Keyword(s):  
Brown Rice ◽  
Germinated Brown Rice ◽  
Physiochemical Properties

Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress

2021 ◽  
pp. 1-9
Author(s):  
Shipra Bhatt ◽  
Ankita Sharma ◽  
Ashish Dogra ◽  
Priyanka Sharma ◽  
Amit Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury

A polysaccharide of PFP-1 from Pleurotus geesteranus attenuates alcoholic liver diseases via Nrf2 and NF-κB signaling pathways

2021 ◽  
Author(s):  
Xinling Song ◽  
Wenxue Sun ◽  
Wenxin Cai ◽  
Le Jia ◽  
Jianjun Zhang
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Liver Injury ◽  
Signaling Pathways ◽  
Alcoholic Liver Disease ◽  
Fruiting Body ◽  
Liver Diseases ◽  
Alcoholic Liver Diseases

A polysaccharide named as PFP-1 was isolated from Pleurotus geesteranus fruiting body, and the potential investigations on ameliorating oxidative stress and liver injury against alcoholic liver disease (ALD) were processed...

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