Determination of Oxalate Content in Herbal Remedies and Dietary Supplements Based on Plant Extracts

2016 ◽  
Vol 19 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Roswitha Siener ◽  
Montserrat López-Mesas ◽  
Manuel Valiente ◽  
Francisco Blanco
Keyword(s):  
Dietary Supplements ◽  
Plant Extracts ◽  
Herbal Remedies

scholarly journals A Health Risk Assessment of Lead and Other Metals in Pharmaceutical Herbal Products and Dietary Supplements Containing Ginkgo biloba in the Mexico City Metropolitan Area

2021 ◽  
Vol 18 (16) ◽  
pp. 8285
Author(s):  
Patricia Rojas ◽  
Elizabeth Ruiz-Sánchez ◽  
Camilo Ríos ◽  
Ángel Ruiz-Chow ◽  
Aldo A. Reséndiz-Albor
Keyword(s):  
Health Risk ◽  
Dietary Supplements ◽  
Mexico City ◽  
Metropolitan Area ◽  
Ginkgo Biloba ◽  
Graphite Furnace ◽  
Human Health Risk ◽  
Daily Intake ◽  
Herbal Remedies ◽  
Herbal Products

The use of the medicinal plant Ginkgo biloba has increased worldwide. However, G. biloba is capable of assimilating both essential and toxic metals, and the ingestion of contaminated products can cause damage to health. The aim of this study was to investigate the safety of manganese (Mn), copper (Cu), lead (Pb), arsenic (As), and cadmium (Cd) in 26 items containing Ginkgo biloba (pharmaceutical herbal products, dietary supplements, and traditional herbal remedies) purchased in the metropolitan area of Mexico City. Metal analysis was performed using a graphite furnace atomic absorption spectrometer. All of the products were contaminated with Pb, 54% of them with As, and 81% with Cd. The lowest values of Pb, As, and Cd were detected in pharmaceutical herbal products > dietary supplements > traditional herbal remedies. The daily intake dose (DID) of pharmaceutical herbal products was within the established limits for the five metals. Dietary supplements and traditional herbal remedies exceeded the DID limits for Pb. The hazard quotients estimation and non-carcinogenic cumulative hazard estimation index for Mn, As, and Cd indicated no human health risk. Our results suggest that products containing G. biloba for sale in Mexico are not a health risk.

scholarly journals Intra-Laboratory Validation of Alpha-Galactosidase Activity Measurement in Dietary Supplements

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1566
Author(s):  
Elena Fabris ◽  
Michela Bulfoni ◽  
Alessandro Nencioni ◽  
Emanuele Nencioni
Keyword(s):  
Dietary Supplements ◽  
Good Manufacturing Practice ◽  
Activity Measurement ◽  
Intermediate Precision ◽  
Method Performance ◽  
Intestinal Gas ◽  
Technical Requirements ◽  
Ich Guidelines ◽  
Alpha Galactosidase

Introduction: Alpha-galactosidase (α-Gal) is an enzyme responsible for the hydrolyzation of glycolipids and glycoprotein commonly found in dietary sources. More than 20% of the general population suffers from abdominal pain or discomfort caused by intestinal gas and by indigested or partially digested food residuals. Therefore, α-Gal is used in dietary supplements to reduce intestinal gases and help complex food digestion. Marketed enzyme-containing dietary supplements must be produced in accordance with the Food and Drug Administration (FDA) regulations for Current Good Manufacturing Practice (cGMPs). Aim: in this work we illustrated the process used to develop and validate a spectrophotometric enzymatic assay for α-Gal activity quantification in dietary supplements. Methods: The validation workflow included an initial statistical-phase optimization of materials, reagents, and conditions, and subsequently a comparative study with another fluorimetric assay. A final validation of method performance in terms of specificity, linearity, accuracy, intermediate-precision repeatability, and system precision was then executed. Results and conclusions: The proven method achieved good performance in the quantitative determination of α-Gal activity in commercial food supplements in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals (ICH) guidelines and is suitable as a rapid in-house quality control test.

Capillary zone electrophoretic determination of phenolic compounds in chess (Bromus inermisL.) plant extracts

2006 ◽  
Vol 29 (2) ◽  
pp. 308-313 ◽  
Author(s):  
Dagmar Štěrbová ◽  
Jiří Vlček ◽  
Vlastimil Kubáň
Keyword(s):  
Phenolic Compounds ◽  
Plant Extracts ◽  
Capillary Zone
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