scholarly journals Ethanol Extract of Persimmon Tree Leaves Improves Blood Circulation and Lipid Metabolism in Rats Fed a High-Fat Diet

2015 ◽  
Vol 18 (7) ◽  
pp. 715-723 ◽  
Author(s):  
Ri Ryu ◽  
Hye-Jin Kim ◽  
Byeongseok Moon ◽  
Un Ju Jung ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Blood Circulation ◽  
Ethanol Extract ◽  
Tree Leaves ◽  
High Fat

scholarly journals Effect of Lythrum salicaria L. Ethanol Extract on Lipid Metabolism and Anti-Obesity in Rat Fed High Fat Diet

2011 ◽  
Vol 19 (5) ◽  
pp. 319-324 ◽  
Author(s):  
Hee-Yeon Kim ◽  
Sang-Hyun Lim ◽  
Chang-Ju Kwon ◽  
Yu-Hwa Park ◽  
Kwang-Jae Lee ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Lythrum Salicaria ◽  
High Fat

scholarly journals Effect of Keishibukuryogan on Genetic and Dietary Obesity Models

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Fengying Gao ◽  
Satoru Yokoyama ◽  
Makoto Fujimoto ◽  
Koichi Tsuneyama ◽  
Ikuo Saiki ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Rat Model ◽  
High Fat Diet ◽  
Blood Circulation ◽  
The Body ◽  
Kampo Medicine ◽  
High Fat ◽  
Scavenging Effect ◽  
Dietary Obesity ◽  
Mouse Obesity

Obesity has been recognized as one of the most important risk factors for a variety of chronic diseases, such as diabetes, hypertension/cardiovascular diseases, steatosis/hepatitis, and cancer. Keishibukuryogan (KBG, Gui Zhi Fu Ling Wan in Chinese) is a traditional Chinese/Japanese (Kampo) medicine that has been known to improve blood circulation and is also known for its anti-inflammatory or scavenging effect. In this study, we evaluated the effect of KBG in two distinct rodent models of obesity driven by either a genetic (SHR/NDmcr-cp rat model) or dietary (high-fat diet-induced mouse obesity model) mechanism. Although there was no significant effect on the body composition in either the SHR rat or the DIO mouse models, KBG treatment significantly decreased the serum level of leptin and liver TG level in the DIO mouse, but not in the SHR rat model. Furthermore, a lower fat deposition in liver and a smaller size of adipocytes in white adipose tissue were observed in the DIO mice treated with KBG. Importantly, we further found downregulation of genes involved in lipid metabolism in the KBG-treated liver, along with decreased liver TG and cholesterol level. Our present data experimentally support in fact that KBG can be an attractive Kampo medicine to improve obese status through a regulation of systemic leptin level and/or lipid metabolism.

scholarly journals Polygoni Multiflori Radix Praeparata Ethanol Extract Exerts a Protective Effect Against High-Fat Diet Induced Non-Alcoholic Fatty Liver Disease in Mice by Remodeling Intestinal Microbial Structure and Maintaining Metabolic Homeostasis of Bile Acids

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuyang Dai ◽  
Linfeng He ◽  
Naihua Hu ◽  
Chaocheng Guo ◽  
Mengting Zhou ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Dose Group ◽  
Intestinal Barrier ◽  
Ethanol Extract ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

In the prescription of Traditional Chinese Medicine for lipid metabolism, Polygoni Multiflori Radix Preparata (ZhiHeShouWu, RPMP) was widely used. In recent years, RPMP ethanol extract has been reported for the treatment of non-alcoholic fatty liver disease (NAFLD). However, the role of RPMP ethanol extract in the treatment of NAFLD has not been fully elucidated. Therefore, we examined the optimal therapeutic dose of RPMP ethanol extracts. Afterward, a mouse model of non-alcoholic fatty liver induced by a high-fat diet (HFD) was treated with RPMP ethanol extract to further evaluate the mechanism of action of RPMP ethanol extract treatment. And the serum lipid metabolism indexes and liver function indexes showed that the RPMP ethanol extract in the 1.35 g/kg dose group exhibited better therapeutic effects than the 2.70 g/kg dose group. Meanwhile, RPMP ethanol extract can regulate the biochemical indicators of serum and liver to normal levels, and effectively reduce liver steatosis and lipid deposition. RPMP ethanol extract treatment restored HFD-induced disruption of the compositional structure of the intestinal microbial (IM) and bile acids (BAs) pools. And restore the reduced expression of intestinal barrier-related genes caused by HFD administration, which also effectively regulates the expression of genes related to the metabolism of BAs in mice. Thus, RPMP ethanol extract can effectively improve the abnormal lipid metabolism and hepatic lipid accumulation caused by HFD, which may be related to the regulation of IM composition, maintenance of intestinal barrier function, and normal cholesterol metabolism in the body.

Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats

2018 ◽  
Vol 9 (12) ◽  
pp. 6268-6278 ◽  
Author(s):  
Yu-Yang Pan ◽  
Feng Zeng ◽  
Wei-Ling Guo ◽  
Tian-Tian Li ◽  
Rui-Bo Jia ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Grifola Frondosa ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition

This study aimed to investigate the effects of 95% ethanol extract of G. frondosa (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats.

Effect of Aceriphyllum rossii Ethanol Extract on Lipid Metabolism in Rats Fed a High-Fat Diet

2011 ◽  
Vol 40 (10) ◽  
pp. 1411-1416 ◽  
Author(s):  
Yu-Hwa Park ◽  
Hee-Yeon Kim ◽  
Sang-Hyun Lim ◽  
Kyung-Hee Kim ◽  
Dong-Sik Park ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
High Fat ◽  
Aceriphyllum Rossii

scholarly journals Effect of Marine Microalga Chlorella pyrenoidosa Ethanol Extract on Lipid Metabolism and Gut Microbiota Composition in High-Fat Diet-Fed Rats

Marine Drugs ◽  
2018 ◽  
Vol 16 (12) ◽  
pp. 498 ◽  
Author(s):  
Xuzhi Wan ◽  
Tiantian Li ◽  
Dan Liu ◽  
Yihan Chen ◽  
Yuanyuan Liu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Chlorella Pyrenoidosa ◽  
Rrna Gene ◽  
Regulation Mechanism ◽  
High Fat ◽  
Food Ingredients ◽  
Marine Microalga

Effects of marine microalga Chlorella pyrenoidosa 55% ethanol extract (CPE55) on lipid metabolism, gut microbiota and regulation mechanism in high fat diet-fed induced hyperlipidaemia rats were investigated. Structure characterizations of major compounds in CPE55 were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry (UPLC-Q-TOF-MS/MS). The compositions of gut microbiota in rats were analyzed by high-throughput next-generation 16S rRNA gene sequencing. Oral administration with CPE55 markedly alleviated dyslipidemia through improving adverse blood lipid profile and inhibiting hepatic lipid accumulation and steatosis. CPE55 has downregulated the gene expression levels of acetyl CoA carboxylase, sterol regulatory element-binding transcription factor-1c, and 3-hydroxy-3-methyl glutaryl coenzyme A reductase and upregulated adenosine 5′-monophosphate-activated protein kinase-α. It has also improved the abundance of bacteria Alistipes, Prevotella, Alloprevotella, and Ruminococcus1 and decreased the abundances of Turicibacter and Lachnospira. Turicibacter and Lachnospira were both positive correlations of metabolic phenotypes. The findings above illustrated that CPE55 might be developed as food ingredients to ameliorate lipid metabolic disorders and hyperlipidaemia.

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