scholarly journals Oral Administration of Vaccinium uliginosum L. Extract Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice

2014 ◽  
Vol 17 (12) ◽  
pp. 1350-1360 ◽  
Author(s):  
Kang-Hyun Kim ◽  
Se-Young Choung
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Vaccinium Uliginosum

scholarly journals Mixture of Polyphenols and Anthocyanins fromVaccinium uliginosum L.Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Min Ju Kim ◽  
Se-Young Choung
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Clinical Signs ◽  
Inflammatory Cells ◽  
Biological Properties ◽  
Dependent Manner ◽  
Protective Effects ◽  
Vaccinium Uliginosum ◽  
Skin Photoaging ◽  
Th1 Cytokine

Vaccinium uliginosum L. (VU) possesses various biological properties, such as antioxidant and protective effects against VU-induced skin photoaging. The purpose of this study is to evaluate the effects of oral administration of a mixture of polyphenols and anthocyanins derived from VU on 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis (AD) in NC/Nga mice. We assessed anti-AD effects in NC/Nga murine model for a period of 9 weeks. Oral administration of the mixture significantly alleviated the AD-like skin symptoms and clinical signs including ear thickness and scratching behaviors. Orally administrated mixture reduced the level of IgE and IgG1, whereas it increased the level of IgG2a in a dose-dependent manner. The calculated IgG1/IgG2a ratio for each mouse revealed that the mixture derived from VU also significantly reduced the Th2/Th1 ratio, IL-4 and IL-13 (as Th2 cytokines), IFN-γ, and IL-12 (as a Th1 cytokine) in spleens. In addition, it significantly decreased gene expression, such as IL-4, IL-5, CCR3, eotaxin-1, IL- 12, IFN-γ, MCP-1, and IL-17, in AD-like lesions and suppressed Th17. Histological analyses revealed that the epidermis thickness and number of inflammatory cells were significantly reduced. In conclusion, oral administration of the mixture in the DNCB-induced AD is confirmed to improve AD disease in mice.

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis

2018 ◽  
Vol 154 (1) ◽  
pp. 37 ◽  
Author(s):  
Vicente Navarro-López ◽  
Ana Ramírez-Boscá ◽  
Daniel Ramón-Vidal ◽  
Beatriz Ruzafa-Costas ◽  
Salvador Genovés-Martínez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Young Patients ◽  
Topical Steroids ◽  
Probiotic Strains

Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-γ down-regulation in NC/Nga mice

2009 ◽  
Vol 122 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Dong-Young Kim ◽  
Jung-A Jung ◽  
Tae-Ho Kim ◽  
Sang-Wan Seo ◽  
Sung-Ki Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Down Regulation ◽  
Ifn Γ

Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice

2003 ◽  
Vol 3 (9) ◽  
pp. 1313-1324 ◽  
Author(s):  
Yoshifumi Taniguchi ◽  
Keizo Kohno ◽  
Shin-ichiro Inoue ◽  
Satomi Koya-Miyata ◽  
Iwao Okamoto ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Royal Jelly ◽  
Skin Lesions

scholarly journals Oral Administration of Acidic Xylooligosaccharides Prevents the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2010 ◽  
Vol 56 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Takayuki OHBUCHI ◽  
Makoto SAKAINO ◽  
Tetsunari TAKAHASHI ◽  
Naoya AZUMI ◽  
Kotaro ISHIKAWA ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions
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