Production of Bioactive Compounds with Antitumor Activity Against Sarcoma 180 by Pleurotus sajor-caju

2013 ◽  
Vol 16 (11) ◽  
pp. 1004-1012 ◽  
Author(s):  
Ivaneliza Simionato Assis ◽  
Mariane Bonatti Chaves ◽  
Marcia Luciane Lange Silveira ◽  
Regina Maria Miranda Gern ◽  
Elisabeth Wisbeck ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Bioactive Compounds ◽  
Sarcoma 180 ◽  
Pleurotus Sajor Caju

Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla

2015 ◽  
Vol 70 (5-6) ◽  
pp. 129-137 ◽  
Author(s):  
Aline L. Xavier ◽  
João Carlos L.R. Pita ◽  
Monalisa T. Brito ◽  
Déborah R.P. Meireles ◽  
Josean F. Tavares ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Antitumor Activity ◽  
Liver Function ◽  
Essential Oil ◽  
Pharmacological Study ◽  
Hematological Toxicity ◽  
Sarcoma 180 ◽  
Hemolytic Assay ◽  
In Vivo Antitumor Activity

Abstract The chemical composition, antitumor activity and toxicity of the essential oil from Lippia microphylla leaves (OEL) were investigated. The major constituents were thymol (46.5%), carvacrol (31.7%), p-cymene (9%), and γ-terpinene (2.9%). To evaluate the toxicity of OEL in non-tumor cells, the hemolytic assay with Swiss mice erythrocytes was performed. The concentration producing 50% hemolysis (HC50) was 300 μg/mL. Sarcoma 180 tumor growth was inhibited in vivo 38% at 50 mg/kg, and 60% at 100 mg/kg, whereas 5-FU at 50 mg/kg caused 86% inhibition. OEL displays moderate gastrointestinal and hematological toxicity along with causing some alteration in liver function and morphology. However, the changes were considered reversible and negligible in comparison to the effects of several anticancer drugs. In summary, OEL displays in vivo antitumor activity and a moderate toxicity, which suggests further pharmacological study.

Analysis of the antitumor activity of bioactive compounds of Cannabis flowers extracted by green solvents

2019 ◽  
Vol 149 ◽  
pp. 20-25 ◽  
Author(s):  
Daniel Ribeiro Grijó ◽  
Danielle Lazarin Bidoia ◽  
Celso Vataru Nakamura ◽  
Ignacio Vieitez Osorio ◽  
Lúcio Cardozo-Filho
Keyword(s):  
Antitumor Activity ◽  
Bioactive Compounds ◽  
Green Solvents

scholarly journals IN VIVO ANTITUMOR ACTIVITY OF PHYTOCHEMICAL PITC-2 OBTAINED FROM TISSUE CULTURED PLANT PLUCHEA INDICA ON SARCOMA-180 SOLID TUMOR MICE MODEL

2018 ◽  
Vol 11 (4) ◽  
pp. 211
Author(s):  
Soumita Goswami ◽  
Souvik Debnath ◽  
Saumen Karan ◽  
Tapan Kumar Chatterjee
Keyword(s):  
Antitumor Activity ◽  
Solid Tumor ◽  
Sarcoma 180 ◽  
Tumor Cell Proliferation ◽  
Mice Model ◽  
Ki 67 ◽  
Cycle Arrest ◽  
In Vivo Antitumor Activity ◽  
G1 Cell Cycle Arrest

 Objective: PITC-2 was isolated from the methanolic root extract of tissue cultured medicinal plant Pluchea indica (L.) Less. PITC-2 is a thiophene derivative which is 2-(Prop-1-ynyl)-5(5,6-dihydroxyhexa-1,3-diynyl)-thiophene. The main objective of the study is to evaluate the in vivo antitumor activity of PITC 2 against sarcoma-180 cancer cell in Swiss albino mice.Methods: The antitumor activity was evaluated by treatment with PITC-2 at a dose of 2.5 and 5 mg/kg b.w for 21 days on sarcoma-180 mice model. Cell viability was studied using 3-(4, 5- dimethylthiazol -2-yl)-2, 5-diphenyl tetrazolium bromide assay and cell apoptosis, G1 cell cycle arrest and reduction in tumor cell proliferation were evaluated by histopathological analysis and Bcl-2, cyclic-D1, and Ki-67 protein expression through immunohistochemistry study.Results: Precisely, PITC-2 had a cytotoxic effect on various in vitro cancer cells. Significant decreases in solid tumor volume and weight along with increase lifespan also observed. The histopathological and immunohistopathological examination indicates that PITC-2 induces apoptosis, typical morphological changes and suppresses tumor cell proliferation along with G1 cell cycle arrest through the downregulation of the intratumoral expression of Bcl-2, cyclic D1, and Ki-67 and thus highlighting antiproliferative and apoptotic properties against sarcoma-180 in vivo solid tumor model.Conclusion: The present results clearly demonstrate that PITC-2 significantly inhibits sarcoma-180 cell growth in a dose-dependent manner in in vivo mice model. Besides this, the study reveals a comprehensive perception of the possible mechanism behind the antitumor activity of PITC-2 by significant changes in the morphological, hematological, biochemical parameters in sarcoma-180 cells.

scholarly journals Antitumor Activity of the Carboplatin-α-Cyclodextrin Adduct

1997 ◽  
Vol 4 (6) ◽  
pp. 305-306
Author(s):  
Weiping Liu ◽  
Huizhou Xiong ◽  
Yikun Yang ◽  
Ling Li ◽  
Zhiqiang Shen ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Antitumor Efficacy ◽  
Sarcoma 180 ◽  
Murine Tumors ◽  
Ehrlich Ascites

Antitumor activity of the adduct between Carboplatin and α-cyclodextrin has been tested against Sarcoma 180 (S180) and Ehrlich ascites carcinoma (EAC) murine tumors. The preliminary toxicity has also been evaluated by histological examinations of the treated animals. The results show the adduct has less antitumor efficacy than and similar toxicity to Carboplatin.

Effects of carp and tuna oils on 5-fluorouracil-induced antitumor activity and side effects in sarcoma 180-bearing mice

Lipids ◽  
2001 ◽  
Vol 36 (4) ◽  
pp. 353-359 ◽  
Author(s):  
Yoshiyuki Kimura ◽  
Takeshi Takaku ◽  
Shigeru Nakajima ◽  
Hiromichi Okuda
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Sarcoma 180

Discovering new anti-cancer drugs from extremophilic microorganisms

2021 ◽  
Author(s):  
Miguel Pérez Rodríguez
Keyword(s):  
Drug Discovery ◽  
Antitumor Activity ◽  
Bioactive Compounds ◽  
New Technologies ◽  
Atlantic Coast ◽  
Extreme Environments ◽  
Biological Data ◽  
Drug Candidates ◽  
Public Health Challenges ◽  
Extremophilic Microorganisms

Bio Knowledge Lab (hereinafter BKL) is a young company from Cordoba in the biotechnology and bioinformatics sector specialized in the implementation of massive sequencing projects and computer analysis of biological data. Its objective is to support research groups and companies that work in areas related to life sciences, biotechnology, biomedicine or biopharmaceuticals. In addition, in parallel, BKL also develops its own lines of research. Among them, the project “Bioprospecting of extreme environments of the Andalusian Atlantic coast for the isolation of new bioactive compounds with antitumor activity”, a public-private project carried out in collaboration with the Universities of Huelva and Granada, and aimed to search for new compounds from extremophilic microorganisms. This project can be framed within the area of ​​Drug Discovery, a process by which new drug candidates are discovered. This constitutes the initial stage of the entire development of a drug, a process that is long and expensive, mainly due to the low ratio of drug candidates that can finally be brought to market. For this reason, there are many attempts to innovate in the drug discovery process, for example, through new approaches or using new technologies. Here, omics and computational approaches, as well as the use of new sources of resources, could provide the innovation that this process needs to overcome the public health challenges it faces. In this line, these are the approaches proposed by BKL and its collaborators, all of them integrated into a novel bioprospecting project. The project "Bioprospecting of extreme environments of the Andalusian Atlantic coast for the isolation of new bioactive compounds with antitumor activity" aims to study the microbiodiversity of extreme environments and identify microorganisms of interest, carry out isolations of new microbial species, especially microalgae and archaea, and obtain from them functional extracts rich in bioactive components to evaluate their antioxidant and antitumor capacity. In this first stage of the process, the studied locations have been points of interest of Marismas del Odiel, the Riotinto Mines and the phospho-gypsum pools, all of them in the province of Huelva and characterized by hosting extreme environments, either due to their high salinity, due to its high content of heavy metals and / or its radioactivity. In our project, the microbial, eukaryotic and prokaryotic populations of these environments have been characterized. In addition, two haloarchaeas and four microalgae have been isolated and functional extracts have been obtained, and their antioxidant and antitumor potential has been evaluated, the latter in colorectal cancer models.

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