scholarly journals Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts

2014 ◽  
Vol 34 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Zhiguang Ping ◽  
Jianxun Qi ◽  
Yanling Sun ◽  
Guangwen Lu ◽  
Yi Shi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Interferon Gamma ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Gamma Receptor ◽  
Receptor Alpha Chain

scholarly journals Ligand-induced assembly and activation of the gamma interferon receptor in intact cells.

1996 ◽  
Vol 16 (6) ◽  
pp. 3214-3221 ◽  
Author(s):  
E A Bach ◽  
J W Tanner ◽  
S Marsters ◽  
A Ashkenazi ◽  
M Aguet ◽  
...  
Keyword(s):  
Gamma Interferon ◽  
Beta Chain ◽  
Ifn Gamma ◽  
Intracellular Domain ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Gamma Receptor ◽  
Receptor Beta ◽  
Receptor Alpha Chain

Functionally active gamma interferon (IFN-gamma) receptors consist of an alpha subunit required for ligand binding and signal transduction and a beta subunit required primarily for signaling. Although the receptor alpha chain has been well characterized, little is known about the specific role of the receptor beta chain in IFN-gamma signaling. Expression of the wild-type human IFN-gamma receptor beta chain in murine L cells that stably express the human IFN-gamma receptor alpha chain (L.hgR) produced a murine cell line (L.hgR.myc beta) that responded to human IFN-gamma. Mutagenesis of the receptor beta-chain intracellular domain revealed that only two closely spaced, membrane-proximal sequences (P263PSIP267 and I270EEYL274) are required for function. Coprecipitation studies showed that these sequences are necessary for the specific and constitutive association of the receptor beta chain with the JAK-2 tyrosine kinase. These experiments also revealed that the IFN-gamma receptor alpha and beta chains are not preassociated on the surface of unstimulated cells but rather are induced to associate in an IFN-gamma-dependent fashion. A chimeric protein in which the intracellular domain of the beta chain was replaced by JAK-2 complemented human IFN-gamma signaling and biologic responsiveness in L.hgR. In contrast, a c-src-containing beta-chain chimera did not. These results indicate that the sole obligate role of the IFN-gamma receptor beta chain in signaling is to recruit JAK-2 into the ligand-assembled receptor complex.

Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML

2009 ◽  
Vol 45 (9) ◽  
pp. 1692-1699 ◽  
Author(s):  
Monique Terwijn ◽  
Nicole Feller ◽  
Anna van Rhenen ◽  
Angèle Kelder ◽  
Guus Westra ◽  
...  
Keyword(s):  
Residual Disease ◽  
Interleukin 2 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Cd25 Expression ◽  
Interleukin 2 Receptor ◽  
Receptor Alpha Chain

scholarly journals Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice.

1991 ◽  
Vol 88 (17) ◽  
pp. 7518-7522 ◽  
Author(s):  
H. Koseki ◽  
H. Asano ◽  
T. Inaba ◽  
N. Miyashita ◽  
K. Moriwaki ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
Alpha Chain ◽  
Receptor Alpha Chain

scholarly journals Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology

Blood ◽  
2000 ◽  
Vol 96 (4) ◽  
pp. 1267-1273 ◽  
Author(s):  
Cem Akin ◽  
Lawrence B. Schwartz ◽  
Takashi Kitoh ◽  
Hirokazu Obayashi ◽  
Alexandra S. Worobec ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cell ◽  
Disease Severity ◽  
Bone Marrow Biopsy ◽  
Systemic Mastocytosis ◽  
Bone Marrow Involvement ◽  
Surrogate Markers ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Receptor Alpha Chain

Abstract Systemic mastocytosis is a disease of mast cell proliferation that may be associated with hematologic disorders. There are no features on examination that allow the diagnosis of systemic disease, and mast cell–derived mediators, which may be elevated in urine or blood, may also be elevated in individuals with severe allergic disorders. Thus, the diagnosis usually depends on results of bone marrow biopsy. To facilitate evaluation, surrogate markers of the extent and severity of the disease are needed. Because of the association of mastocytosis with hematologic disease, plasma levels were measured for soluble KIT (sKIT) and soluble interleukin-2 receptor alpha chain (sCD25), which are known to be cleaved in part from the mast cell surface and are elevated in some hematologic malignancies. Results revealed that levels of both soluble receptors are increased in systemic mastocytosis. Median plasma sKIT concentrations as expressed by AU/mL (1 AU = 1.4 ng/mL) were as follows: controls, 176 (n = 60); urticaria pigmentosa without systemic involvement, 194 (n = 8); systemic indolent mastocytosis, 511 (n = 30); systemic mastocytosis with an associated hematologic disorder, 1320 (n = 7); aggressive mastocytosis, 3390 (n = 3). Plasma sCD25 levels were elevated in systemic mastocytosis; the highest levels were associated with extensive bone marrow involvement. Levels of sKIT correlated with total tryptase levels, sCD25 levels, and bone marrow pathology. These results demonstrate that sKIT and sCD25 are useful surrogate markers of disease severity in patients with mastocytosis and should aid in diagnosis, in the selection of those needing a bone marrow biopsy, and in the documentation of disease progression.

scholarly journals Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 ◽  
Vol 13 (20) ◽  
pp. 4765-4775 ◽  
Author(s):  
D.J. Hilton ◽  
A.A. Hilton ◽  
A. Raicevic ◽  
S. Rakar ◽  
M. Harrison-Smith ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Affinity Binding ◽  
High Affinity Binding ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
High Affinity ◽  
Receptor Alpha Chain

scholarly journals Immunologic crossreactivity between platelet GP IIb and the vitronectin receptor alpha chain by using monoclonal anti-IIb antibodies [letter; comment]

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 318-319 ◽  
Author(s):  
E Muniz-Diaz ◽  
C Castell Arnau ◽  
A Ribera ◽  
P Madoz ◽  
J Gonzalez Rodriguez
Keyword(s):  
Vitronectin Receptor ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Letter Comment ◽  
Receptor Alpha Chain
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