In Vitro Performance of Spacers for Aerosol Delivery during Adult Mechanical Ventilation

2015 ◽  
Vol 28 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Nabile Boukhettala ◽  
Thierry Porée ◽  
Patrice Diot ◽  
Laurent Vecellio
Keyword(s):  
Mechanical Ventilation ◽  
Aerosol Delivery ◽  
In Vitro Performance

Aerosol Delivery During Mechanical Ventilation: A Predictive In-Vitro Lung Model

1992 ◽  
Vol 5 (4) ◽  
pp. 251-259 ◽  
Author(s):  
H.D. FULLER ◽  
M.B. DOLOVICH ◽  
C. CHAMBERS ◽  
M.T. NEWHOUSE
Keyword(s):  
Mechanical Ventilation ◽  
Lung Model ◽  
Aerosol Delivery

Therapeutic Aerosol Delivery during Mechanical Ventilation

1996 ◽  
Vol 30 (6) ◽  
pp. 644-655 ◽  
Author(s):  
Denise M Coleman ◽  
H William Kelly ◽  
Bennie C Mcwilliams ◽  
Annette Pérez ◽  
Marc M Perreault
Keyword(s):  
Mechanical Ventilation ◽  
Case Reports ◽  
Data Extraction ◽  
Case Series ◽  
Aerosol Delivery ◽  
Delivery Device ◽  
Unique Challenge ◽  
Medline Search

Objective To provide an overview of aerosol drug delivery during mechanical ventilation in the pediatric and adult populations. Data Sources Published articles and abstracts identified in a MEDLINE search (1984–July 1994) were reviewed. Study Selection All articles and abstracts found, including review articles, in vivo and in vitro studies, case reports, and case series pertaining to issues involving aerosol delivery during mechanical ventilation, were reviewed. No predetermined selection criteria were used to exclude studies. Data Extraction Percent delivery of the starting dose to either the patients or the various in vitro lung models, as well as each variable possibly affecting delivery for each study, were tabulated for each study reviewed. Data Synthesis The delivery of therapeutic aerosols to endotracheally intubated and mechanically ventilated patients presents a unique challenge for healthcare providers. Delivery can be affected by the diameter of the endotracheal tube and ventilator circuitry, type of ventilator, ventilator modes, type of delivery device, and how the delivery device is operated and introduced into the ventilator circuitry. The drug being aerosolized may behave differently from one delivery system to another. The proper operation of each device requires attention to positioning in the ventilator circuit as well as the mode of ventilation. Conclusions No apparent advantage exists for metered-dose inhalers with a large-volume adapter over jet nebulizers, as each method of delivery is capable of similar efficiency (5–15%). Sufficient attention to detail, including the use of an efficient nebulizer and/or adapter and proper placement and operating method, is required to provide optimal delivery. For bronchodilator administration, careful monitoring of outcomes will provide the most optimal dosing schedule.

scholarly journals Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

2017 ◽  
Vol 3 (1) ◽  
pp. 233-241 ◽  
Author(s):  
Haitham Saeed ◽  
Ahmed A. Elberry ◽  
Abeer Salah Eldin ◽  
Hoda Rabea ◽  
Mohamed E. A. Abdelrahim
Keyword(s):  
Mechanical Ventilation ◽  
Invasive Mechanical Ventilation ◽  
Aerosol Delivery ◽  
Non Invasive ◽  
Vitro Data ◽  
In Vitro Data ◽  
Modeling Study

In vitro evaluation of aerosol delivery of aztreonam lysine (AZLI): an adult mechanical ventilation model

2017 ◽  
Vol 14 (12) ◽  
pp. 1447-1453 ◽  
Author(s):  
Alejandro Rodríguez ◽  
María Cabrera ◽  
Luis F. Reyes ◽  
María Bodí ◽  
Sandra Trefler ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Aerosol Delivery ◽  
In Vitro Evaluation

In vitro study and semiempirical model for aerosol delivery control during mechanical ventilation

2005 ◽  
Vol 31 (6) ◽  
pp. 871-876 ◽  
Author(s):  
Laurent Vecellio ◽  
Claude Guérin ◽  
Daniel Grimbert ◽  
Michele De Monte ◽  
Patrice Diot
Keyword(s):  
Mechanical Ventilation ◽  
In Vitro Study ◽  
Vitro Study ◽  
Semiempirical Model ◽  
Aerosol Delivery

scholarly journals Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 721 ◽  
Author(s):  
Kyung Hwa Chang ◽  
Sang-Hyub Moon ◽  
Sun Kook Yoo ◽  
Bong Joo Park ◽  
Ki Chang Nam
Keyword(s):  
Enzymatic Activity ◽  
Drug Stability ◽  
Aerosol Delivery ◽  
Clinical Safety ◽  
Dornase Alfa ◽  
Jet Nebulizer ◽  
Jet Nebulizers ◽  
In Vitro Performance ◽  
Delivery Efficiency

Recent reports on mesh nebulizers suggest the possibility of stable nebulization of various therapeutic protein drugs. In this study, the in vitro performance and drug stability of jet and mesh nebulizers were examined for dornase alfa and compared with respect to their lung delivery efficiency in BALB/c mice. We compared four nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U150), and a vibrating mesh nebulizer (NE-SM1). The enzymatic activity of dornase alfa was assessed using a kinetic fluorometric DNase activity assay. Both jet nebulizers had large residual volumes between 24% and 27%, while the volume of the NE-SM1 nebulizer was less than 2%. Evaluation of dornase alfa aerosols produced by the four nebulizers showed no overall loss of enzymatic activity or protein content and no increase in aggregation or degradation. The amount of dornase alfa delivered to the lungs was highest for the PARI BOY SX-red jet nebulizer. This result confirmed that aerosol droplet size is an important factor in determining the efficiency of dornase alfa delivery to the lungs. Further clinical studies and analysis are required before any conclusions can be drawn regarding the clinical safety and efficacy of these nebulizers.

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