scAAV9 Intracisternal Delivery Results in Efficient Gene Transfer to the Central Nervous System of a Feline Model of Motor Neuron Disease

2013 ◽  
Vol 24 (7) ◽  
pp. 670-682 ◽  
Author(s):  
Thomas Bucher ◽  
Marie-Anne Colle ◽  
Erin Wakeling ◽  
Laurence Dubreil ◽  
John Fyfe ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Efficient Gene ◽  
The Central Nervous System ◽  
Feline Model

scholarly journals Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65

2018 ◽  
Vol 10 ◽  
pp. 197-209 ◽  
Author(s):  
Eloise Hudry ◽  
Eva Andres-Mateos ◽  
Eli P. Lerner ◽  
Adrienn Volak ◽  
Olivia Cohen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
Efficient Gene ◽  
The Central Nervous System

Skin and Bones—and Muscle Too

Bioprinting ◽  
2021 ◽  
pp. 98-118
Author(s):  
Kenneth Douglas
Keyword(s):  
Skeletal Muscle ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Membrane ◽  
Motor Neuron ◽  
Neuromuscular Junctions ◽  
Skeletal Muscle Cell ◽  
The Body ◽  
The Central Nervous System ◽  
Judicious Choice

Abstract: This chapter recounts bioprinting studies of skin, bone, skeletal muscle, and neuromuscular junctions. The chapter begins with a study of bioprinted skin designed to enable the creation of skin with a uniform pigmentation. The chapter relates two very different approaches to bioprinted bone: a synthetic bone called hyperelastic bone and a strategy that prints cartilage precursors to bone and then induces the conversion of the cartilage to bone by judicious choice of bioinks. Muscles move bone, and the chapter discusses an investigation of bioprinted skeletal muscle. Finally, the chapter considers an attempt to bioprint a neuromuscular junction, a synapse—a minute gap—of about 20 billionths of a meter between a motor neuron and the cell membrane of a skeletal muscle cell. A motor neuron is a nerve in the central nervous system that sends signals to the muscles of the body.

scholarly journals Methods for Gene Transfer to the Central Nervous System

2014 ◽  
pp. 125-197 ◽  
Author(s):  
Boris Kantor ◽  
Rachel M. Bailey ◽  
Keon Wimberly ◽  
Sahana N. Kalburgi ◽  
Steven J. Gray
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
The Central Nervous System

Dopamine modulation of gill reflex behavior in Aplysia

1979 ◽  
Vol 57 (3) ◽  
pp. 329-332 ◽  
Author(s):  
Peter Ruben ◽  
Ken Lukowiak
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Motor Neuron ◽  
Peripheral Nervous System ◽  
Motor Neurons ◽  
Withdrawal Reflex ◽  
Dopaminergic Pathway ◽  
The Central Nervous System ◽  
Dopamine Modulation

We have studied the effects of dopamine on the gill withdrawal reflex evoked by tactile siphon stimulation in the margine mollusc Aplysia. Physiological concentrations of dopamine (diluted in seawater) were perfused through the gill during siphon stimulation series. The amplitude of the reflex was potentiated by dopamine and habituation of the reflex was prevented. This occurred with no change in the activity evoked in central motor neurons. These results lead us to conclude that the dopaminergic motor neuron L9 is modulating habituation in the periphery and that the central nervous system facilitatory control of the peripheral nervous system may act via a dopaminergic pathway.

Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system

2000 ◽  
Vol 2 (3) ◽  
pp. 165-175 ◽  
Author(s):  
Reuben Matalon ◽  
Peter L. Rady ◽  
Kenneth A. Platt ◽  
Henry B. Skinner ◽  
Michael J. Quast ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
Canavan Disease ◽  
Knock Out ◽  
The Central Nervous System ◽  
Knock Out Mouse
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