scholarly journals Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna

2014 ◽  
Vol 1 ◽  
pp. 14051 ◽  
Author(s):  
Christian Hinderer ◽  
Peter Bell ◽  
Charles H Vite ◽  
Jean-Pierre Louboutin ◽  
Rebecca Grant ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
Cisterna Magna ◽  
Cynomolgus Macaques ◽  
The Central Nervous System

scholarly journals Pioneers in the cisterna magna puncture

2020 ◽  
Vol 78 (3) ◽  
pp. 176-178
Author(s):  
Thiago Ferreira Simões DE SOUZA
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Clinical Applications ◽  
Alternative Route ◽  
Cisterna Magna ◽  
Relative Safety ◽  
The Central Nervous System ◽  
Promising Source ◽  
Diagnosis Of Diseases

Abstract At the beginning of the 20th century, cerebrospinal fluid (CSF) collection and analysis emerged as a promising aid in the diagnosis of diseases of the central nervous system. It was obtained through the established procedure of lumbar puncture, described by Heinrich Quinke in 1891. The search for an alternative way to gather the CSF emerged in animal research, highlighting the cisterna magna as a promising source, with relative safety when performed by someone trained. Described initially and in detail by James Ayer in 1920, the procedure was widely adopted by neurologists and psychiatrists at the time, featuring its multiple advantages and clinical applications. After a period of great procedure use and exponential data collection, its complications and risks relegated the puncture of the cisterna magna as an alternative route that causes fear and fascination in modern Neurology.

scholarly journals Methods for Gene Transfer to the Central Nervous System

2014 ◽  
pp. 125-197 ◽  
Author(s):  
Boris Kantor ◽  
Rachel M. Bailey ◽  
Keon Wimberly ◽  
Sahana N. Kalburgi ◽  
Steven J. Gray
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
The Central Nervous System

Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system

2000 ◽  
Vol 2 (3) ◽  
pp. 165-175 ◽  
Author(s):  
Reuben Matalon ◽  
Peter L. Rady ◽  
Kenneth A. Platt ◽  
Henry B. Skinner ◽  
Michael J. Quast ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
Canavan Disease ◽  
Knock Out ◽  
The Central Nervous System ◽  
Knock Out Mouse

Adenovirus-Mediated Gene Transfer to the Central Nervous System for Parkinson's Disease

1997 ◽  
Vol 144 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Philippe Horellou ◽  
Olivier Sabaté ◽  
Marie-Hélène Buc-Caron ◽  
Jacques Mallet
Keyword(s):  
Parkinson’S Disease ◽  
Central Nervous System ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Gene Transfer ◽  
The Central Nervous System

Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications

2006 ◽  
Vol 17 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Liang-Fong Wong ◽  
Lucy Goodhead ◽  
Christine Prat ◽  
Kyriacos A. Mitrophanous ◽  
Susan M. Kingsman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Transfer ◽  
The Central Nervous System
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