The Effect of Dietary Nitrate on Nocturnal Sleep-Disordered Breathing and Arterial Oxygen Desaturation at High Altitude

2018 ◽  
Vol 19 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Alexander Patrician ◽  
Harald Engan ◽  
David Lundsten ◽  
Ludger Grote ◽  
Helena Vigetun-Haughey ◽  
...  
Keyword(s):  
High Altitude ◽  
Sleep Disordered Breathing ◽  
Oxygen Desaturation ◽  
Arterial Oxygen ◽  
Nocturnal Sleep ◽  
Dietary Nitrate ◽  
Disordered Breathing

scholarly journals Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude

2004 ◽  
Vol 23 (1) ◽  
pp. 47-52 ◽  
Author(s):  
R. Fischer ◽  
S.M. Lang ◽  
M. Leitl ◽  
M. Thiere ◽  
U. Steiner ◽  
...  
Keyword(s):  
High Altitude ◽  
Sleep Disordered Breathing ◽  
Disordered Breathing

scholarly journals Cardiometabolic correlates of sleep disordered breathing in Andean highlanders

2017 ◽  
Vol 49 (6) ◽  
pp. 1601705 ◽  
Author(s):  
Luu V. Pham ◽  
Catherine H. Miele ◽  
Noah G. Schwartz ◽  
Rafael S. Arias ◽  
Adi Rattner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Disordered Breathing ◽  
Cell Function ◽  
Arterial Oxygen Saturation ◽  
Sleep Apnoea ◽  
Arterial Oxygen ◽  
Haemoglobin A1c ◽  
Linear Regression Models ◽  
Nocturnal Hypoxaemia ◽  
Disordered Breathing

Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation.Participants (n=187; 91 men) were (median (interquartile range)) 52 (45–62) years old, and had a BMI of 27.0 (24.3–29.5) kg·m−2and 87% (85–88%) oxyhaemoglobin (arterial oxygen) saturation during wakefulness. In fully adjusted models, worsening nocturnal hypoxaemia was associated with haemoglobin elevations in men (p=0.03), independent of wake oxygenation and apnoea–hypopnoea index (AHI), whereas worsening wake oxygenation was associated with haemoglobin elevations in older women (p=0.02). In contrast, AHI was independently associated with HbA1c elevations (p<0.05). In single-variable models, nocturnal hypoxaemia was associated with higher HbA1c, HOMA-IR and HOMA-β (p<0.001, p=0.02 and p=0.04, respectively), whereas AHI was associated with HOMA-IR, systolic blood pressure and triglyceride elevations (p=0.02, p=0.01 and p<0.01, respectively). These associations were not significant in fully adjusted models.In highlanders, nocturnal hypoxaemia and sleep apnoea were associated with distinct cardiometabolic outcomes, conferring differential risk for excessive erythrocytosis and glucose intolerance, respectively.

Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing

2013 ◽  
Vol 34 (5) ◽  
pp. 537-540 ◽  
Author(s):  
Yuki Hara ◽  
Akiko Noda ◽  
Seiko Miyata ◽  
Hironao Otake ◽  
Yoshinari Yasuda ◽  
...  
Keyword(s):  
Sleep Disordered Breathing ◽  
Oxygen Desaturation ◽  
Disordered Breathing

Effects of acetazolamide on sleep disordered breathing in patients with COPD staying at high altitude. RCT

2019 ◽  
Author(s):  
Talantbek Sooronbaev ◽  
Michael Furian ◽  
Lu Tan ◽  
Aline Buergin ◽  
Philipp M. Scheiwiller ◽  
...  
Keyword(s):  
High Altitude ◽  
Sleep Disordered Breathing ◽  
Disordered Breathing
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