Acetazolamide Fails to Decrease Pulmonary Artery Pressure at High Altitude in Partially Acclimatized Humans

2008 ◽  
Vol 9 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Buddha Basnyat ◽  
Jenny Hargrove ◽  
Peter S. Holck ◽  
Soni Srivastav ◽  
Kshitiz Alekh ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure

scholarly journals Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude

2008 ◽  
Vol 32 (3) ◽  
pp. 664-669 ◽  
Author(s):  
S. Kriemler ◽  
C. Jansen ◽  
A. Linka ◽  
A. Kessel-Schaefer ◽  
M. Zehnder ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure

Effect of oxygen upon pulmonary circulation in acclimatized man at high altitude

1965 ◽  
Vol 20 (2) ◽  
pp. 239-243 ◽  
Author(s):  
H. N. Hultgren ◽  
J. Kelly ◽  
H. Miller
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Sea Level ◽  
Pulmonary Artery Pressure ◽  
Pulmonary Circulation ◽  
Arterial Oxygen ◽  
Artery Pressure ◽  
Oxygen Breathing ◽  
Hypoxic Vasoconstriction ◽  
Arteriolar Resistance

The response to breathing 100% oxygen was studied in 26 acclimatized residents of the Peruvian Andes at altitudes of 12,300 and 14,200 ft. Arterial oxygen saturation increased from 86% to 96%. Mean pulmonary artery pressure decreased by 5 mm Hg and cardiac output did not change. Calculated pulmonary arteriolar resistance was lowered. Pulmonary artery pressure during oxygen breathing was not decreased to normal values observed at sea level. The data suggest the presence of two factors responsible for the increase in pulmonary arteriolar resistance at high altitude: 1) hypoxic vasoconstriction which is reversed by oxygen breathing and 2) anatomic alterations which are not affected by oxygen breathing. Oxygen breathing at high altitude also produced a slowing of the heart rate and increased the relative height of the secondary or tidal wave of the brachial arterial pressure pulse. pulmonary arteriolar resistance and 100% oxygen; arterial pulse contour–effect of 100% oxygen at high altitude; pulmonary arteriolar resistance–nature of in high altitude; hypoxic vasoconstriction at high altitude–reversal by 100% oxygen breathing; oxygen breathing–comparison of effect on pulmonary circulation at high altitude and sea level Submitted on May 8, 1964

scholarly journals Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents

2012 ◽  
Vol 13 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Baktybek Kojonazarov ◽  
Jainagul Isakova ◽  
Bakytbek Imanov ◽  
Nurmira Sovkhozova ◽  
Talantbek Sooronbaev ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure

scholarly journals Selective Reductions in Pulmonary Artery Pressure Lowers Sympathetic Neural Activity in Healthy Humans at High Altitude

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Lydia L Simpson ◽  
Andrew Steele ◽  
Victoria L Meah ◽  
Suman Thapamagar ◽  
Christopher Gasho ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Neural Activity ◽  
Artery Pressure ◽  
Healthy Humans

Effect of acute and subacute exposure and reexposure to high altitude on pulmonary artery pressure in healthy lowlanders

2017 ◽  
Author(s):  
Mona Lichtblau ◽  
Patrick Raphael Bader ◽  
Michael Furian ◽  
Lara Muralt ◽  
Sara E. Hartmann ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure ◽  
Subacute Exposure

scholarly journals Inhibition of phosphodiesterase-5 and nitric oxide similarly reduce pulmonary artery pressure at high altitude

2003 ◽  
Vol 41 (6) ◽  
pp. 257-258
Author(s):  
Hans P. Brunner-La Rocca ◽  
Patrick Egger ◽  
Oliver Senn ◽  
Manuel Fischler ◽  
Rahel Thalmann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure ◽  
Phosphodiesterase 5

Impact of acute hypoxic pulmonary hypertension on LV diastolic function in healthy mountaineers at high altitude

2004 ◽  
Vol 286 (3) ◽  
pp. H856-H862 ◽  
Author(s):  
Yves Allemann ◽  
Martin Rotter ◽  
Damian Hutter ◽  
Ernst Lipp ◽  
Claudio Sartori ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
High Altitude ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Healthy Subjects ◽  
Artery Pressure ◽  
Altitude Exposure ◽  
Low Altitude ◽  
Lv Diastolic Function

In pulmonary hypertension right ventricular pressure overload leads to abnormal left ventricular (LV) diastolic function. Acute high-altitude exposure is associated with hypoxia-induced elevation of pulmonary artery pressure particularly in the setting of high-altitude pulmonary edema. Tissue Doppler imaging (TDI) allows assessment of LV diastolic function by direct measurements of myocardial velocities independently of cardiac preload. We hypothesized that in healthy mountaineers, hypoxia-induced pulmonary artery hypertension at high altitude is quantitatively related to LV diastolic function as assessed by conventional and TDI Doppler methods. Forty-one healthy subjects (30 men and 11 women; mean age 41 ± 12 yr) underwent transthoracic echocardiography at low altitude (550 m) and after a rapid ascent to high altitude (4,559 m). Measurements included the right ventricular to right atrial pressure gradient (ΔPRV-RA), transmitral early ( E) and late ( A) diastolic flow velocities and mitral annular early ( Em) and late ( Am) diastolic velocities obtained by TDI at four locations: septal, inferior, lateral, and anterior. At a high altitude, ΔPRV-RA increased from 16 ± 7to44 ± 15 mmHg ( P < 0.0001), whereas the transmitral E-to- A ratio ( E/ A ratio) was significantly lower (1.11 ± 0.27 vs. 1.41 ± 0.35; P < 0.0001) due to a significant increase of A from 52 ± 15 to 65 ± 16 cm/s ( P = 0.0001). ΔPRV-RA and transmitral E/ A ratio were inversely correlated ( r2 = 0.16; P = 0.0002) for the whole spectrum of measured values (low and high altitude). Diastolic mitral annular motion interrogation showed similar findings for spatially averaged (four locations) as well as for the inferior and septal locations: Am increased from low to high altitude (all P < 0.01); consequently, Em/ Am ratio was lower at high versus low altitude (all P < 0.01). These intraindividual changes were reflected interindividually by an inverse correlation between ΔPRV-RA and Em/ Am (all P < 0.006) and a positive association between ΔPRV-RA and Am (all P < 0.0009). In conclusion, high-altitude exposure led to a two- to threefold increase in pulmonary artery pressure in healthy mountaineers. This acute increase in pulmonary artery pressure led to a change in LV diastolic function that was directly correlated with the severity of pulmonary hypertension. However, in contrast to patients suffering from some form of cardiopulmonary disease and pulmonary hypertension, in these healthy subjects, overt LV diastolic dysfunction was not observed because it was prevented by augmented atrial contraction. We propose the new concept of compensated diastolic (dys)function.

Pulmonary artery pressure and cardiac function in children and adolescents after rapid ascent to 3,450 m

2012 ◽  
Vol 302 (12) ◽  
pp. H2646-H2653 ◽  
Author(s):  
Yves Allemann ◽  
Thomas Stuber ◽  
Stefano F. de Marchi ◽  
Emrush Rexhaj ◽  
Claudio Sartori ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Right Ventricular ◽  
High Altitude ◽  
Children And Adolescents ◽  
Pulmonary Artery Pressure ◽  
Young Population ◽  
Artery Pressure ◽  
Rapid Ascent ◽  
Low Altitude

High-altitude destinations are visited by increasing numbers of children and adolescents. High-altitude hypoxia triggers pulmonary hypertension that in turn may have adverse effects on cardiac function and may induce life-threatening high-altitude pulmonary edema (HAPE), but there are limited data in this young population. We, therefore, assessed in 118 nonacclimatized healthy children and adolescents (mean ± SD; age: 11 ± 2 yr) the effects of rapid ascent to high altitude on pulmonary artery pressure and right and left ventricular function by echocardiography. Pulmonary artery pressure was estimated by measuring the systolic right ventricular to right atrial pressure gradient. The echocardiography was performed at low altitude and 40 h after rapid ascent to 3,450 m. Pulmonary artery pressure was more than twofold higher at high than at low altitude (35 ± 11 vs. 16 ± 3 mmHg; P < 0.0001), and there existed a wide variability of pulmonary artery pressure at high altitude with an estimated upper 95% limit of 52 mmHg. Moreover, pulmonary artery pressure and its altitude-induced increase were inversely related to age, resulting in an almost twofold larger increase in the 6- to 9- than in the 14- to 16-yr-old participants (24 ± 12 vs. 13 ± 8 mmHg; P = 0.004). Even in children with the most severe altitude-induced pulmonary hypertension, right ventricular systolic function did not decrease, but increased, and none of the children developed HAPE. HAPE appears to be a rare event in this young population after rapid ascent to this altitude at which major tourist destinations are located.

scholarly journals Pulmonary-Artery Pressure and Exhaled Nitric Oxide in Bolivian and Caucasian High Altitude Dwellers

2008 ◽  
Vol 9 (4) ◽  
pp. 295-299 ◽  
Author(s):  
Marcos Schwab ◽  
Pierre-Yves Jayet ◽  
Thomas Stuber ◽  
Carlos E. Salinas ◽  
Jonathan Bloch ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Exhaled Nitric Oxide ◽  
Artery Pressure
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