Virulotyping and Antimicrobial Resistance Typing ofSalmonella entericaSerovars Relevant to Human Health in Europe

2010 ◽  
Vol 7 (5) ◽  
pp. 523-535 ◽  
Author(s):  
Stephan Huehn ◽  
Roberto M. La Ragione ◽  
Muna Anjum ◽  
Mark Saunders ◽  
Martin J. Woodward ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Human Health

Recent Review on Subclass B1 Metallo-β-lactamases Inhibitors: Sword for Antimicrobial Resistance

2019 ◽  
Vol 20 (7) ◽  
pp. 756-762 ◽  
Author(s):  
Aditi Kaushik ◽  
Manish Kaushik ◽  
Viney Lather ◽  
J.S. Dua
Keyword(s):  
Antibiotic Resistance ◽  
Multidrug Resistance ◽  
Antimicrobial Resistance ◽  
Global Health ◽  
Human Health ◽  
Microbial Pathogens ◽  
Present Review ◽  
Drug Molecules ◽  
Global Threat ◽  
Powerful Strategy

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations, posing a global threat to human health. The production of the metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Till date, there are no clinically active drugs against metallo- β-lactamase. The lack of efficient drug molecules against MBLs carrying bacteria requires continuous research efforts to overcome the problem of multidrug-resistance bacteria. The present review will discuss the clinically potent molecules against different variants of B1 metallo-β-lactamase.

scholarly journals The Australian Group on Antimicrobial Resistance (AGAR)

2019 ◽  
Vol 40 (2) ◽  
pp. 69 ◽  
Author(s):  
Geoffrey Coombs ◽  
Denise Daley ◽  
Jan Bell ◽  
on behalf of the Australian Group on Antimicrobial Resistance
Keyword(s):  
Antimicrobial Resistance ◽  
Human Health ◽  
Medical Microbiology ◽  
Life Threatening

The Australian Group on Antimicrobial Resistance (AGAR) is a collaboration of clinicians and scientists working in diagnostic medical microbiology laboratories located across Australia. The group gathers information on the level of antimicrobial resistance (AMR) in bacteria causing important and life threatening infections and is a key component of Australia's response to the problem of increasing AMR. It defines where Australia stands with regard to antimicrobial resistance in human health.

scholarly journals Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?

mSphere ◽  
2019 ◽  
Vol 4 (5) ◽  
Author(s):  
Alex Wong
Keyword(s):  
Antimicrobial Resistance ◽  
Human Health ◽  
The United States ◽  
Evidence Base ◽  
Systematic Investigation ◽  
Current Evidence ◽  
Cross Resistance ◽  
Unknown Risk ◽  
Current Evidence Base ◽  
Agricultural Use

ABSTRACT Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact human health. Consequently, these drugs have not been subject to the same regulations as medically important antibiotics. Here, I argue that the current evidence base is insufficient to conclude that ionophores do not contribute to human relevant antimicrobial resistance. It is unclear whether ionophore resistance can result in cross-resistance to medically important antibiotics. Moreover, recent evidence suggests that ionophore use may coselect for resistance to vancomycin in some cases. Systematic investigation of the consequences of agricultural ionophore use for human health is therefore imperative.

scholarly journals AN IMPLICATION OF ACTINOMYCETES ON HUMAN WELL-BEING: A REVIEW

2019 ◽  
pp. 11-18
Author(s):  
ALI MOHAMMED ABDULLAH BAWAZIR ◽  
PALAKSHA ◽  
MANJULA SHANTARAM ◽  
MANJULA SHANTARAM
Keyword(s):  
Antimicrobial Resistance ◽  
Secondary Metabolites ◽  
Human Health ◽  
Antimicrobial Agents ◽  
Well Being ◽  
Pathogenic Microorganisms ◽  
Antibiotic Resistant ◽  
Bioactive Secondary Metabolites ◽  
Resistant Strains ◽  
All Diseases

This review conceptualizes about the actinomycetes and its contribution to human health by playing a key role as bioactive secondary metabolites, such as enzymes, antibiotics and pigments, leading to their diverse applications and use in various industries. These searches have been uncommonly successful, and around 66% of naturally happening antibiotics, including many medically important, have been isolated from actinomycetes. The speedy occurrence of antimicrobial resistance among pathogens has led to a renewed interest to search for novel antimicrobial agents, but these antibiotics are not enough for the treatment of all diseases because there is a berserk requirement for a novel actinomycetes to combat against the antibiotic-resistant strains of pathogenic microorganisms, which are quickly expanding bit by bit. Actinomycetes are the important providers to the pharmaceutical and other industries and are well known for their capacity to produce secondary metabolites many of which are active against pathogenic microorganisms.

scholarly journals The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward

2015 ◽  
Vol 370 (1670) ◽  
pp. 20140085 ◽  
Author(s):  
Frank M. Aarestrup
Keyword(s):  
Antimicrobial Resistance ◽  
Human Health ◽  
Antimicrobial Agents ◽  
Negative Impact ◽  
Current Knowledge ◽  
Global Burden ◽  
Antimicrobial Use ◽  
Personal View ◽  
Emerging Issues ◽  
Changing Patterns

The purpose of this review was to provide an updated overview on the use of antimicrobial agents in livestock, the associated problems for humans and current knowledge on the effects of reducing resistance in the livestock reservoir on both human health and animal production. There is still limiting data on both use of antimicrobial agents, occurrence and spread of resistance as well as impact on human health. However, in recent years, emerging issues related to methicillin-resistant Staphylococcus aureus , Clostridium difficile , Escherichia coli and horizontally transferred genes indicates that the livestock reservoir has a more significant impact on human health than was estimated 10 years ago, where the focus was mainly on resistance in Campylobacter and Salmonella . Studies have indicated that there might only be a marginal if any benefit from the regular use of antibiotics and have shown that it is possible to substantially reduce the use of antimicrobial agents in livestock production without compromising animal welfare or health or production. In some cases, this should be done in combination with other measures such as biosecurity and use of vaccines. To enable better studies on both the global burden and the effect of interventions, there is a need for global harmonized integrated and continuous surveillance of antimicrobial usage and antimicrobial resistance, preferably associated with data on production and animal diseases to determine the positive and negative impact of reducing antimicrobial use in livestock.

scholarly journals Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health

2013 ◽  
Vol 15 (7) ◽  
pp. 1917-1942 ◽  
Author(s):  
Felipe C. Cabello ◽  
Henry P. Godfrey ◽  
Alexandra Tomova ◽  
Larisa Ivanova ◽  
Humberto Dölz ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Human Health ◽  
Antimicrobial Use

scholarly journals Strengthening strategic management approaches to address antimicrobial resistance in global human health: a scoping review

2019 ◽  
Vol 4 (5) ◽  
pp. e001730 ◽  
Author(s):  
Raheelah Ahmad ◽  
Nina Jiayue Zhu ◽  
Andrew J M Leather ◽  
Alison Holmes ◽  
Ewan Ferlie
Keyword(s):  
Antimicrobial Resistance ◽  
Strategic Management ◽  
Human Health ◽  
Financial Incentives ◽  
The Political ◽  
Management Approach ◽  
Cost Shifting ◽  
Strategic Plans ◽  
Retrospective View ◽  
Management Approaches

IntroductionThe development and implementation of national strategic plans is a critical component towards successfully addressing antimicrobial resistance (AMR). This study aimed to review the scope and analytical depth of situation analyses conducted to address AMR in human health to inform the development and implementation of national strategic plans.MethodsA systematic search of the literature was conducted to identify all studies since 2000, that have employed a situation analysis to address AMR. The included studies are analysed against frameworks for strategic analysis, primarily the PESTELI (Political, Economic, Sociological, Technological, Ecological, Legislative, Industry) framework, to understand the depth, scope and utility of current published approaches.Results10 studies were included in the final review ranging from single country (6) to regional-level multicountry studies (4). 8 studies carried out documentary review, and 3 of these also included stakeholder interviews. 2 studies were based on expert opinion with no data collection. No study employed the PESTELI framework. Most studies (9) included analysis of the political domain and 1 study included 6 domains of the framework. Technological and industry analyses is a notable gap. Facilitators and inhibitors within the political and legislative domains were the most frequently reported. No facilitators were reported in the economic or industry domains but featured inhibiting factors including: lack of ring-fenced funding for surveillance, perverse financial incentives, cost-shifting to patients; joint-stock drug company ownership complicating regulations.ConclusionThe PESTELI framework provides further opportunities to combat AMR using a systematic, strategic management approach, rather than a retrospective view. Future analysis of existing quantitative data with interviews of key strategic and operational stakeholders is needed to provide critical insights about where implementation efforts should be focussed, and also how to build contingency at the strategic level for agile responses to macro-level environmental influences.

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