Monitoring of Thermal Dose During Ablation Therapy Using Quantum Dot-Mediated Fluorescence Thermometry

2010 ◽  
Vol 24 (12) ◽  
pp. 1903-1908 ◽  
Author(s):  
Karim Bensalah ◽  
Altug Tuncel ◽  
Willard Hanson ◽  
Joshua Stern ◽  
Bumsoo Han ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Thermal Dose ◽  
Ablation Therapy ◽  
Fluorescence Thermometry

Performance Assessment of Probe for Radio-Frequency Ablation

Volume 4 ◽  
2004 ◽  
Author(s):  
Ashvinikumar V. Mudaliar ◽  
Elaine P. Scott
Keyword(s):  
Temperature Distribution ◽  
Radio Frequency ◽  
Tumor Tissue ◽  
Healthy Tissue ◽  
Lower Portion ◽  
Distribution Data ◽  
Thermal Dose ◽  
Rf Ablation ◽  
Ablation Therapy ◽  
Tissue Region

Radio-frequency (RF) ablation is one of the most widely used methods for the treatment of hepatic malignancies. A finite element method (FEM) analysis was employed to determine the thermal dose delivered to the tumor/tissue region. We simulated heating within a RF probe implanted in generic tumor surrounded by healthy tissue using ANSYS. The 3-D model consists of a tumor / tissue region into which the RF probe is embedded inside the tumor. One-quarter symmetry was then invoked. The blood flow was modeled using Penne’s bio-heat transfer equation with differing perfusion rates between the healthy tissue and tumor volume based on literature values. The resulting temperature distribution throughout the region was determined over time. A program was written in Visual Basic to extract the temperature distribution data in the tumor/tissue region and calculate the thermal dose throughout the region. This was done by using a time–temperature Arrhenius relationship for chemical and physical rate process. Tissue necrosis is assumed complete when a thermal dose of one hour has been achieved at 43 °C. In the present study, the geometry of the electrode had a significant effect on the size of the volume of necrosis. It was found that the lower portion of the tumor did not receive the specified thermal dose relative to the upper portion of the tumor in single setting during the RF ablation therapy. This might be due to the Ni-Ti electrode, which protruded only from the top surface of the trocar. The effectiveness of the existing probe can be improved by having one more set of electrodes protruding out from the lower curved surface of the trocar. It was found that the modified probe significantly improved heating in the lower portion of tumor/tissue area, providing more symmetry between the upper and lower portion.

scholarly journals Absorption efficiency of gold nanorods determined by quantum dot fluorescence thermometry

2012 ◽  
Vol 100 (20) ◽  
pp. 201110 ◽  
Author(s):  
L. M. Maestro ◽  
P. Haro-González ◽  
J. G. Coello ◽  
D. Jaque
Keyword(s):  
Quantum Dot ◽  
Gold Nanorods ◽  
Absorption Efficiency ◽  
Fluorescence Thermometry

Facile synthesis of gold/gadolinium-doped carbon quantum dot nanocomposites for magnetic resonance imaging and photothermal ablation therapy

2017 ◽  
Vol 5 (31) ◽  
pp. 6282-6291 ◽  
Author(s):  
Gangaraju Gedda ◽  
Yueh-Yun Yao ◽  
Si-Han Chen ◽  
Anil V. Ghule ◽  
Yong-Chien Ling ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Quantum Dot ◽  
Resonance Imaging ◽  
Facile Synthesis ◽  
Ablation Therapy ◽  
Carbon Quantum Dot ◽  
Photothermal Ablation ◽  
Gold Nanomaterials

Composites of gold nanomaterials and imaging agents show promise in cancer therapy.

Effects of light–tissue interaction on quantum dot mediated fluorescence thermometry

2012 ◽  
Vol 23 (4) ◽  
pp. 045704 ◽  
Author(s):  
Soham Ghosh ◽  
Willard Hanson ◽  
Najma Abdollahzadeh ◽  
Bumsoo Han
Keyword(s):  
Quantum Dot ◽  
Tissue Interaction ◽  
Fluorescence Thermometry

Development of Quantum Dot-Mediated Fluorescence Thermometry for Thermal Therapies

2009 ◽  
Vol 37 (6) ◽  
pp. 1230-1239 ◽  
Author(s):  
Bumsoo Han ◽  
Willard L. Hanson ◽  
Karim Bensalah ◽  
Altug Tuncel ◽  
Joshua M. Stern ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Thermal Therapies ◽  
Fluorescence Thermometry
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