Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

2013 ◽  
Vol 1 (3) ◽  
pp. 127-137 ◽  
Author(s):  
Jason D. Smith ◽  
Lee E. Weiss ◽  
James E. Burgess ◽  
Alan I. West ◽  
Phil G. Campbell
Keyword(s):  
Blood Plasma ◽  
Tissue Repair ◽  
Biologically Active ◽  
New Paradigm

PRP application in dermatology: review of current approaches

2021 ◽  
pp. 55-58
Author(s):  
V. V. Bondarenko
Keyword(s):  
Growth Factors ◽  
Blood Plasma ◽  
Tissue Repair ◽  
Skin Diseases ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Biologically Active ◽  
Tissue Repair And Regeneration ◽  
Positive Results ◽  
Active Substances

In recent years, the possibilities of a dermatologist in the treatment of patients with chronic dermatoses have significantly expanded due to the emergence of new highly effective methods, such as autologous blood plasma enriched with platelet-rich-growth factors (platelet-rich-plasma, PRP). The positive results of using this technology due to its constituent growth factors, cytokines and other biologically active substances, which have a pronounced normalizing effect on the processes of tissue repair and regeneration, expands the possibilities of its use in such skin diseases as erosive and ulcerative lichen planus, scleroatrophic lichen, acne and post-acne. The aim of this review was to analyze the literature on the mechanisms of PRP action in patients with dermatological diseases.

Abstract 55: Opposing Roles Of Distinct Macrophage Lineages In Heart Failure And Cardiac Recovery

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Kory J Lavine ◽  
Slava Epelman ◽  
Keita Uchida ◽  
Kassandra J Weber ◽  
Joel D Schilling ◽  
...  
Keyword(s):  
Heart Failure ◽  
Tissue Repair ◽  
Cardiomyocyte Proliferation ◽  
New Paradigm ◽  
Chemokine Production ◽  
Adult Heart ◽  
Cardiac Recovery ◽  
Novel Treatments ◽  
Inflammatory Monocytes ◽  
Embryonic Origin

Why inflammation is simultaneously deleterious following injury and essential for tissue repair continues to be fundamentally important and debated question. Recently, a new paradigm has emerged in the macrophage field: that organs are replete with resident macrophages of embryonic origin, distinct from monocyte-derived macrophages. This added complexity raises the question of whether distinct immune cells drive inflammatory and reparative activities following injury. Previous work has demonstrated that the neonatal heart has a remarkable capacity for tissue repair compared to the adult, offering an ideal context to examine these concepts. We hypothesized that unrecognized differences in macrophage composition in the neonatal and adult heart represents a key determinant of cardiac recovery. To test this hypothesis, we generated a novel cardiomyocyte ablation model and demonstrated that following injury neonatal mice expand a population of resident cardiac macrophages derived from embryonic lineages, which generate minimal inflammation and are necessary and sufficient for cardiac recovery through promotion of cardiomyocyte proliferation and angiogenesis. During homeostasis the adult heart also contained embryonic-derived macrophages with similar properties. However, following injury these cells disappeared, and instead, the adult heart recruited pro-inflammatory monocytes and monocyte-derived macrophages that lacked reparative activities. Inhibition of monocyte recruitment into the injured adult heart preserved embryonic-derived macrophage subsets, reduced inflammatory cytokine and chemokine production, and enhanced tissue repair. Together, these findings indicate that embryonic-derived macrophages, rather than monocyte-derived macrophages, are key mediators of cardiac recovery. Therapeutics targeting distinct macrophage and monocyte lineages may serve as novel treatments for heart failure.

scholarly journals Neuro–Immune Cell Units: A New Paradigm in Physiology

2019 ◽  
Vol 37 (1) ◽  
pp. 19-46 ◽  
Author(s):  
Cristina Godinho-Silva ◽  
Filipa Cardoso ◽  
Henrique Veiga-Fernandes
Keyword(s):  
Adipose Tissue ◽  
Paradigm Shift ◽  
Tissue Repair ◽  
Immune Cell ◽  
The Body ◽  
New Paradigm ◽  
Environmental Signals ◽  
The Past ◽  
Physiological Processes ◽  
The Impact

The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environmental signals are sensed by discrete neuro–immune cell units (NICUs), which represent defined anatomical locations in which immune and neuronal cells colocalize and functionally interact to steer tissue physiology and protection. These units have now been described in multiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers. As such, NICUs are emerging as important orchestrators of multiple physiological processes, including hematopoiesis, organogenesis, inflammation, tissue repair, and thermogenesis. In this review we focus on the impact of NICUs in tissue physiology and how this fast-evolving field is driving a paradigm shift in our understanding of immunoregulation and organismal physiology.

scholarly journals Supplementation with Sodium Selenite and Selenium-Enriched Microalgae Biomass Show Varying Effects on Blood Enzymes Activities, Antioxidant Response, and Accumulation in Common Barbel (Barbus barbus)

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Antonín Kouba ◽  
Josef Velíšek ◽  
Alžběta Stará ◽  
Jiří Masojídek ◽  
Pavel Kozák
Keyword(s):  
Blood Plasma ◽  
Sodium Selenite ◽  
Control Diet ◽  
Antioxidant Response ◽  
Fish Growth ◽  
Biologically Active ◽  
Fish Mortality ◽  
Barbus Barbus ◽  
Microalgae Biomass ◽  
In Blood Plasma

Yearling common barbel (Barbus barbusL.) were fed four purified casein-based diets for 6 weeks in outdoor cages. Besides control diet, these were supplemented with 0.3 mg kg−1dw selenium (Se) from sodium selenite, or 0.3 and 1.0 mg kg−1from Se-enriched microalgae biomass (Chlorella), a previously untested Se source for fish. Fish mortality, growth, Se accumulation in muscle and liver, and activity of selected enzymes in blood plasma, muscle, liver, and intestine were evaluated. There was no mortality, and no differences in fish growth, among groups. Se concentrations in muscle and liver, activity of alanine aminotransferase and creatine kinase in blood plasma, glutathione reductase (GR) in muscle, and GR and catalase in muscle and liver suggested that selenium from Se-enrichedChlorellais more readily accumulated and biologically active while being less toxic than sodium selenite.

Progress of Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair

2020 ◽  
Vol 26 (17) ◽  
pp. 2022-2037 ◽  
Author(s):  
Guifang Zhao ◽  
Yiwen Ge ◽  
Chenyingnan Zhang ◽  
Leyi Zhang ◽  
Junjie Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Tissue Repair ◽  
Inflammatory Responses ◽  
Biologically Active ◽  
Research Progress ◽  
Tissue Specific

Mesenchymal stem cells (MSCs) are a kind of adult stem cells with self-replication and multidirectional differentiation, which can differentiate into tissue-specific cells under physiological conditions, maintaining tissue self-renewal and physiological functions. They play a role in the pathological condition by lateral differentiation into tissue-specific cells, replacing damaged tissue cells by playing the role of a regenerative medicine , or repairing damaged tissues through angiogenesis, thereby, regulating immune responses, inflammatory responses, and inhibiting apoptosis. It has become an important seed cell for tissue repair and organ reconstruction, and cell therapy based on MSCs has been widely used clinically. The study found that the probability of stem cells migrating to the damaged area after transplantation or differentiating into damaged cells is very low, so the researchers believe the leading role of stem cell transplantation for tissue repair is paracrine secretion, secreting growth factors, cytokines or other components. Exosomes are biologically active small vesicles secreted by MSCs. Recent studies have shown that they can transfer functional proteins, RNA, microRNAs, and lncRNAs between cells, and greatly reduce the immune response. Under the premise of promoting proliferation and inhibition of apoptosis, they play a repair role in tissue damage, which is caused by a variety of diseases. In this paper, the biological characteristics of exosomes (MSCs-exosomes) derived from mesenchymal stem cells, intercellular transport mechanisms, and their research progress in the field of stem cell therapy are reviewed.

STUDY OF WOUND-HEALING EFFECTS OF EXTRACTS OF CERTAIN PLANTS OF THE ARID ZONE

2021 ◽  
Vol 1 (3) ◽  
pp. 335-342
Author(s):  
A.S. Baimukhambetova ◽  
◽  
M.A. Egorov ◽  
A.K. Azhikova ◽  
D.K. Magzanova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plant Species ◽  
Tissue Repair ◽  
Arid Zone ◽  
Glycyrrhiza Glabra ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
White Rats ◽  
Glycyrrhiza Glabra L ◽  
Active Substances

In an experiment on white rats, the regenerating effect of biologically active substances of plant species growing in the Astrakhan region was shown: Achillea micrantha Willd., Helichrysum arenarium, Glycyrrhiza glabra L., Helichrysum nogaicum Tzvel. The article presents data from planimetric studies of damaged skin. The results obtained make it possible to consider extracts as the basis of tissue repair stimulants, as well as to recommend them as anti-inflammatory and wound healing agents.

scholarly journals A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Clara Gallina ◽  
Valentina Turinetto ◽  
Claudia Giachino
Keyword(s):  
Tissue Repair ◽  
Therapeutic Potential ◽  
Tissue Injury ◽  
Cardiac Regeneration ◽  
Heart Tissue ◽  
Trophic Factors ◽  
Preclinical Models ◽  
New Paradigm ◽  
Great Expectations ◽  
The Subject

The potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in humans. It is now clear that the predominant mechanism by which MSCs participate in heart tissue repair is through a paracrine activity. Via the production of a multitude of trophic factors endowed with different properties, MSCs can reduce tissue injury, protect tissue from further adverse effects, and enhance tissue repair. The present review discusses the current understanding of the MSCs secretome as a therapy for treatment of CVD. We provide insights into the possible employment of the MSCs secretome and their released extracellular vesicles as novel approaches for cardiac regeneration that would have certain advantages over injection of living cells.

Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair

2018 ◽  
Vol 6 (1) ◽  
pp. 60-78 ◽  
Author(s):  
I. M. Bjørge ◽  
S. Y. Kim ◽  
J. F. Mano ◽  
B. Kalionis ◽  
W. Chrzanowski
Keyword(s):  
Regenerative Medicine ◽  
Extracellular Vesicles ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
New Paradigm ◽  
Ribonucleic Acids ◽  
Biological Signals

Extracellular vesicles are highly specialized messengers that deliver vital biological signals including ribonucleic acids – key modulators in tissue regeneration.

Injection Molding of ProNectin®F Dispersed in Polystyrene for The Fabrication of Plastic Ware Activated Towards Attachment of Mammalian Cells

1993 ◽  
Vol 330 ◽  
Author(s):  
Erwin R. Stedronsky ◽  
Joseph Cappello ◽  
Samuel David ◽  
David M. Donofrio ◽  
Tina Mcarthur ◽  
...  
Keyword(s):  
Injection Molding ◽  
Mammalian Cell ◽  
Mammalian Cells ◽  
De Novo ◽  
Cell Attachment ◽  
Biologically Active ◽  
Polymeric Surfactant ◽  
New Paradigm

ABSTRACTProNectin®F is a recombinant engineered protein polymer of de novo design which incorporates the RGD epitope recognized by mammalian cell integrins. It is biologically active as a cell attachment protein, manifests properties of a planar polymeric surfactant, and is extremely resistant to thermal degradation. ProNectin®F was dispersed onto polystyrene powder, fabricated into plastic ware through injection molding, and the plastic ware was shown to have cell attachment activity. This technology represents a new paradigm for the production of plastic ware useful for mammalian cell culture under serum free conditions; and more generally, for the production of molded devices for use in contact with cells in vitro or in vivo.

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