Three Genetic Polymorphisms of Homocysteine-Metabolizing Enzymes and Risk of Coronary Heart Disease: Appraisal of a Recent Meta-Analysis

2012 ◽  
Vol 31 (2) ◽  
pp. 135-138
Author(s):  
Feng Pan ◽  
Jing Tian ◽  
Ying Zhang ◽  
Yueyin Pan
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Metabolizing Enzymes

scholarly journals TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Yingchang Lu ◽  
◽  
Jolanda MA Boer ◽  
Roza M Barsova ◽  
Olga Favorova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Genetic Polymorphisms ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Meta Analysis ◽  
Heart Disease Risk

scholarly journals Lipid profile and prognosis in patients with coronary heart disease: a meta-analysis of prospective cohort studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiangmei Zhao ◽  
Dongying Wang ◽  
Lijie Qin
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cohort Studies ◽  
Lipid Profile ◽  
Prospective Cohort ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Prospective Cohort Studies ◽  
All Cause Mortality ◽  
Reduced Risk

Abstract Background This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD). Methods The PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model. Results Twenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels. Conclusions The results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.

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