Antiproliferative Activity of Novel Derivative of Thiopyran on Breast and Colon Cancer Lines and DNA Binding

2012 ◽  
Vol 31 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Mehdi Rajabi ◽  
Mohammad A. Khalilzadeh ◽  
Jamshid Mehrzad
Keyword(s):  
Colon Cancer ◽  
Dna Binding ◽  
Antiproliferative Activity

scholarly journals Antiproliferative Activity of Novel Thiopyran Analogs on MCF-7 Breast and HCT-15 Colon Cancer Cells: Synthesis, Cytotoxicity, Cell Cycle Analysis, and DNA-Binding

2012 ◽  
Vol 22 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Fatemeh Tavakolinia ◽  
Tayebeh Baghipour ◽  
Zinatossadat Hossaini ◽  
Daryoush Zareyee ◽  
Mohammad A. Khalilzadeh ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Dna Binding ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Cell Cycle Analysis ◽  
Colon Cancer Cells ◽  
Mcf 7

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I

2005 ◽  
Vol 15 (17) ◽  
pp. 3930-3933 ◽  
Author(s):  
Rosaria Ottanà ◽  
Stefania Carotti ◽  
Rosanna Maccari ◽  
Ida Landini ◽  
Giuseppa Chiricosta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

scholarly journals Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

2009 ◽  
Vol 7 (3) ◽  
pp. 569-575 ◽  
Author(s):  
Wen-Zhong Zhu ◽  
Rui-Ding Hu ◽  
Qiu-Yue Lin ◽  
Xiao-Xia Wang ◽  
Xiao-Liang Zheng
Keyword(s):  
Dna Binding ◽  
Cell Line ◽  
Elemental Analysis ◽  
Antiproliferative Activity ◽  
Plasmid Dna ◽  
H Nmr ◽  
Smmc7721 Cell ◽  
Calf Thymus ◽  
Binding Experiment ◽  
Pbr322 Plasmid

AbstractTwo novel norcantharidin acylamide acids (HL1=N-pyrimidine norcantharidin acylamide acid, C12H13N3O4; HL2=N-pyridine norcantharidin acylamide acid, C13H14N2O4) were synthesized by a reaction of norcantharidin(NCTD) with 2-aminopyrimidine and 2-aminopyridine, respectively. Their structures were characterized by elemental analysis, IR, UV and 1 H NMR. Fluorescence titration and viscosity measurements indicated that HL1, HL2 and HL3 (HL3=N-phenyl norcantharidin acylamide acid, C14H15NO4) can bind calf thymus DNA via partial intercalation. The liner Stern-Volmer quenching constant Ksv values for HL1, HL2 and HL3 were 2.05 × 104 L mol−1, 1.15 × 104 L mol−1 and 8.30×103 L mol−1, respectively. Two compounds containing heterocycle of HL1 and HL2 have been found to cleave pBR322 plasmid DNA at physiological pH and temperature. The test of antiproliferation activity showed that the compounds had moderate to strong antiproliferative ability against the tested cell lines except of HL3 against the SMMC7721 cell line. The results indicated that the heterocycle attached to the norcantharidin was favorable to antiproliferative activity. This result was consistent with the DNA binding experiment.

scholarly journals Cytotoxic and Antiproliferative Activity of Polyisoprenoids in Seventeen Mangroves Species Against WiDr Colon Cancer Cells

2018 ◽  
Vol 19 (12) ◽  
pp. 3393-3400 ◽  
Author(s):  
Dini P Sari ◽  
Mohammad Basyuni ◽  
Poppy AZ Hasibuan ◽  
Sumardi Sumardi ◽  
Arif Nuryawan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Colon Cancer Cells

Telmisartan Influences the Antiproliferative Activity of Linoleic Acid in Human Colon Cancer Cells

2019 ◽  
Vol 72 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Magdalena Mielczarek-Puta ◽  
Dagmara Otto-Ślusarczyk ◽  
Alicja Chrzanowska ◽  
Agnieszka Filipek ◽  
Wojciech Graboń
Keyword(s):  
Colon Cancer ◽  
Linoleic Acid ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

New binuclear Ni(ii) metallates containing ONS chelators: synthesis, characterisation, DNA binding, DNA cleavage, protein binding, antioxidant activity, antimicrobial and in vitro cytotoxicity

2017 ◽  
Vol 41 (7) ◽  
pp. 2543-2560 ◽  
Author(s):  
G. Kalaiarasi ◽  
Ruchi Jain ◽  
H. Puschman ◽  
S. Poorna Chandrika ◽  
K. Preethi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Protein Binding ◽  
Hela Cell ◽  
Antiproliferative Activity ◽  
Dna Cleavage ◽  
In Vitro Cytotoxicity ◽  
Hela Cell Lines ◽  
Mcf 7

Four new binuclear nickel(ii) metallates showed promising antiproliferative activity against MCF-7 and HeLa cell lines and were much less toxic against HaCaT.

Synthesis, Characterization, DNA-Binding and Antiproliferative Activity of Nd(III) Complexes With N-(Nitrogen Heterocyclic) Norcantharidin Acylamide Acid

2009 ◽  
Vol 19 (5) ◽  
pp. 857-866 ◽  
Author(s):  
Wen-Zhong Zhu ◽  
Qiu-Yue Lin ◽  
Mei Lu ◽  
Rui-Ding Hu ◽  
Xiao-Liang Zheng ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Nitrogen Heterocyclic
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