scholarly journals Antiproliferative Activity of Novel Thiopyran Analogs on MCF-7 Breast and HCT-15 Colon Cancer Cells: Synthesis, Cytotoxicity, Cell Cycle Analysis, and DNA-Binding

2012 ◽  
Vol 22 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Fatemeh Tavakolinia ◽  
Tayebeh Baghipour ◽  
Zinatossadat Hossaini ◽  
Daryoush Zareyee ◽  
Mohammad A. Khalilzadeh ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Dna Binding ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Cell Cycle Analysis ◽  
Colon Cancer Cells ◽  
Mcf 7

Antiproliferative Activity of N6-Isopentenyladenosine on MCF-7 Breast Cancer Cells: Cell Cycle Analysis and DNA-Binding Study

2010 ◽  
Vol 29 (11) ◽  
pp. 687-691 ◽  
Author(s):  
Mehdi Rajabi ◽  
Paola Signorelli ◽  
Elena Gorincioi ◽  
Riccardo Ghidoni ◽  
Enzo Santaniello
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Binding ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Breast Cancer Cells ◽  
Binding Study ◽  
Cell Cycle Analysis ◽  
Mcf 7

scholarly journals Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells

2021 ◽  
Vol 18 (8) ◽  
pp. 4166
Author(s):  
Milena Villarini ◽  
Mattia Acito ◽  
Raffaella di Vito ◽  
Samuele Vannini ◽  
Luca Dominici ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Chlorogenic Acid ◽  
Cancer Cells ◽  
Herbaceous Plant ◽  
Colon Cancer Cells ◽  
Leaf Extracts ◽  
Caffeoylquinic Acids ◽  
Induction Of Apoptosis ◽  
Ht 29

(1) Background: Cynara cardunculus L. subsp. scolymus (L.) Hegi, popularly known as artichoke, is an herbaceous plant belonging to the Asteraceae family. Artichoke leaf extracts (ALEs) have been widely used in traditional medicine because of their hepatoprotective, cholagogic, hypoglycaemic, hypolipemic and antibacterial properties. ALEs are also recognized for their antioxidative and anti-inflammatory activities. In this study, we evaluated the cytotoxic, genotoxic, and apoptotic activities, as well as effect on cell growth of ALEs on human colon cancer HT-29 and RKO cells. HT-29 and RKO cells exhibit a different p53 status: RKO cells express the wild-type protein, whereas HT-29 cells express a p53-R273H contact mutant. (2) Methods: Four different ALEs were obtained by sequential extraction of dried artichoke leaves; ALEs were characterized for their content in chlorogenic acid, cynaropicrin, and caffeoylquinic acids. HT-29 and RKO cells were used for in vitro testing (i.e., cytotoxicity and genotoxicity assessment, cell cycle analysis, apoptosis induction). (3) Results: Two out of the four tested ALEs showed marked effects on cell vitality toward HT-29 and RKO tumour cells. The effect was accompanied by a genotoxic activity exerted at a non-cytotoxic concentrations, by a significant perturbation of cell cycle (i.e., with increase of cells in the sub-G1 phase), and by the induction of apoptosis. (4) Conclusions: ALEs rich in cynaropicrin, caffeoylquinic acids, and chlorogenic acid showed to be capable of affecting HT-29 and RKO colon cancer cells by inducing favourable biological effects: cell cycle perturbation, activation of mitochondrial dependent pathway of apoptosis, and the induction of genotoxic effects probably mediated by the induction of apoptosis. Taken together, these results weigh in favour of a potential cancer chemotherapeutic activity of ALEs.

scholarly journals Cytotoxic and Antiproliferative Activity of Polyisoprenoids in Seventeen Mangroves Species Against WiDr Colon Cancer Cells

2018 ◽  
Vol 19 (12) ◽  
pp. 3393-3400 ◽  
Author(s):  
Dini P Sari ◽  
Mohammad Basyuni ◽  
Poppy AZ Hasibuan ◽  
Sumardi Sumardi ◽  
Arif Nuryawan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Colon Cancer Cells
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