Murine Ortholog of the Novel Glycosyltransferase, B3GTL: Primary Structure, Characterization of the Gene and Transcripts, and Expression in Tissues

2006 ◽  
Vol 25 (8) ◽  
pp. 465-474 ◽  
Author(s):  
Taisto Y.K. Heinonen ◽  
Markku Pelto-Huikko ◽  
Leena Pasternack ◽  
Markku Mäki ◽  
Heikki Kainulainen
Keyword(s):  
Primary Structure ◽  
Structure Characterization ◽  
The Novel

scholarly journals SYNTHESIS, CRYSTAL STRUCTURE, HIRSHFELD SURFACE ANALYSIS AND QUANTUM CHEMICAL CALCULATIONS OF [Cu2(C6H9N3S)2(ClO4)2] π-COMPLEX WITH 2-ALLYLAMINO-5-METHYL-1,3,4-THIADIAZOLE

2021 ◽  
Vol 26 (1(77)) ◽  
pp. 16-25
Author(s):  
Yu. I. Slyvka ◽  
E. A. Goreshnik ◽  
N. T. Pokhodylo ◽  
М. G. Mys’kiv
Keyword(s):  
Crystal Structure ◽  
Computational Analysis ◽  
Structure Characterization ◽  
Electrochemical Technique ◽  
The Novel ◽  
X Ray Diffraction ◽  
X Ray ◽  
Π Complex ◽  
Centrosymmetric Dimers

This work is focused on the synthesis and structure characterization of the novel Cu(I) π-complex [Cu2(Thiaz1)2(ClO4)2] (1) with 2-allylamino-5-methyl-1,3,4-thiadiazole (Thiaz1) ligand. The crystals of the compound were obtained by means of the alternating-current electrochemical technique and studied using single crystal X-ray diffraction. The crystal structure of the complex 1 is constructed from the centrosymmetric dimers, in which two copper(I) ions are coordinated by two Thiaz1 molecules through thiadiazole N atoms and allylic C=C bond. Energy framework computational analysis for structure 1 has been performed.  

scholarly journals Primary Structure Characterization of the Photosystem II D1 and D2 Subunits

1997 ◽  
Vol 272 (52) ◽  
pp. 33158-33166 ◽  
Author(s):  
Jyoti Sharma ◽  
Maria Panico ◽  
Catherine A. Shipton ◽  
Fredrick Nilsson ◽  
Howard R. Morris ◽  
...  
Keyword(s):  
Photosystem Ii ◽  
Primary Structure ◽  
Structure Characterization

Characterization of CDR3 Structure of Vβ21 T Cell Clones In Patients with P210BCR-ABL Positive CML and B-ALL

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4455-4455
Author(s):  
Xianfeng Zha ◽  
Shaohua Chen ◽  
Lijian Yang ◽  
Bo Li ◽  
Yu Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Primary Structure ◽  
Three Dimensional ◽  
Structure Characterization ◽  
Sequencing Analysis ◽  
Amino Acid Motif ◽  
Cdr3 Region ◽  
Cell Clones ◽  
Tumor Associated Antigen

Abstract Abstract 4455 The clonally expanded T cells identified in most cancer patients which were considered to respond to tumour association antigen (TAA) have definitely specific anti-tumor cytotoxicity. P210BCR-ABL protein regards as the hallmark of CML and known to be causative of the disease, and also expresses in partial acute lymphoblastic leukaemia (ALL) can induce to yield tumor-specific cytotoxic T lymphocytes (CTL) which can kill bar-abl+ tumor cells in many trials. In our previous study, we found the oligoclonal expansion of TCR Vβ21 subfamily in the peripheral blood (PB) of 8 cases with P210BCR-ABL positive CML and 3 cases with P210BCR-ABL positive B-ALL patients and 1 case with P210BCR-ABL negative B-ALL patients using the genescan technology. To further elucidate the oligoclonal TCR Vβ21 features, we carried out sequencing analysis of CDR3 region of each oligoclonal TCR Vβ21 and determined the primary structure of the CDR3 region. The 12 TCR Vβ21 clones used different Jβ segments, Jβ2.3 segment was used in 4 clones, both Jβ2.1 and Jβ1.1 segments were used in 2 clones respectively, Jβ1.2, Jβ1.3, Jβ2.2 and Jβ2.7 segments were used in 1 clone. Only a conserved amino acid motif (SLxxV) was found within the CDR3 region from 3 patients with CML. Then we constructed the three-dimensional structures of the CDR3 sequences from all 12 clones by homology modeling methods and through pairwise comparing with the three-dimensional structures of all CDR3 sequences, the results showed that the conformation of the CDR3 region either containing the conserved amino acid motif or using the same Jβ segment displayed low similarity. Interesting, the conformation among some clones whose CDR3 region contain different amino acid motif and did not use the same Jβ segment were high resemble. In conclusions, our findings described that the high frequency of TCR Vβ21 subfamily expansion emerged in p210BCR-ABL positive CML and B-ALL patients, and according to perplexing features of CDR3 region, it could not easy to confirmed that the oligoclonal expanded TCR Vβ21 subfamily must recognize to p210BCR-ABL protein, however, primary structure characterization of CDR3 region, in combination with spatial structure features, ultimately might help to identify the tumor-associated antigen immune attack on tumor cell in p210BCR-ABL positive CML or B-ALL patients. Disclosures: Li: The study was supported by grants from National “863” project (No. 2006AA02Z114) and Key project of Natural Science Foundation of Guangdong province, China (No. 05103293, 9251063201000001).: Research Funding.

Preparation and Structure Characterization of Poly(lactide-co-ethylene carbonate) Microspheres

2013 ◽  
Vol 706-708 ◽  
pp. 215-218
Author(s):  
Chun Sheng Cheng ◽  
Ji Yi Yang ◽  
Yu Yue Qin ◽  
Jian Fan ◽  
Tian Rui Zhao ◽  
...  
Keyword(s):  
Encapsulation Efficiency ◽  
Drug Loading ◽  
Ethylene Carbonate ◽  
Structure Characterization ◽  
Biodegradable Microspheres ◽  
The Novel ◽  
Solvent Evaporation Method ◽  
Spherical Surfaces ◽  
Internal Structures

The purpose of this study was to prepare and characterize tinidazole-loaded poly (lactide-co-ethylene carbonate) (PLEC) microspheres. These biodegradable microspheres were prepared by solvent evaporation method. The effect of selected emulsifier, polymer type, and ratio of tinidazole to PLEC were investigated. An aqueous gelatin solution used as emulsifier resulted in uniform microspheres with spherical surfaces. The PLEC microspheres exhibited rough surface and porous internal structures when compared with the PLA microspheres. The ratio of tinidazole to PLEC (1/10) exhibited higher encapsulation efficiency and drug loading of tinidazole. The introduction of hydrophilic PEC content influenced the structure and encapsulation efficiency of microspheres. These results suggest that the novel PLEC microspheres can be useful for drug delivery systems.

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

2018 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Revansiddappa Mohan
Keyword(s):  
Spectral Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Structure Characterization ◽  
Dimethyl Formamide ◽  
The Novel ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Phosphorous Oxychloride

Vilsmeier–Haack reaction of (E)-1-(1-(3,5-difluorophenyl)ethylidene)-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorous oxychloride by conventional method, resulted in the synthesis of title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the novel title compound was done by IR, 1H NMR, 13C NMR and mass spectral analysis.

Characterization of microwave-sintered ceramic composites

1993 ◽  
Vol 51 ◽  
pp. 1136-1137
Author(s):  
X. Zhang ◽  
Y. Pan ◽  
T.T. Meek
Keyword(s):  
Matrix Material ◽  
Maximum Output Power ◽  
Ceramic Matrix Composite ◽  
Ceramic Composites ◽  
Processing Technique ◽  
Structure Characterization ◽  
Alumina Powder ◽  
Maximum Output ◽  
Sintered Ceramic

Industrial microwave heating technology has emerged as a new ceramic processing technique. The unique advantages of fast sintering, high density, and improved materials properties makes it superior in certain respects to other processing methods. This work presents the structure characterization of a microwave sintered ceramic matrix composite.Commercial α-alumina powder A-16 (Alcoa) is chosen as the matrix material, β-silicon carbide whiskers (Third Millennium Technologies, Inc.) are used as the reinforcing element. The green samples consisted of 90 vol% Al2O3 powder and 10 vol% ultrasonically-dispersed SiC whiskers. The powder mixture is blended together, and then uniaxially pressed into a cylindrical pellet under a pressure of 230 MPa, which yields a 52% green density. The sintering experiments are carried out using an industry microwave system (Gober, Model S6F) which generates microwave radiation at 2.45 GHz with a maximum output power of 6 kW. The composites are sintered at two different temperatures (1550°C and 1650°C) with various isothermal processing time intervals ranging from 10 to 20 min.

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