scholarly journals Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes

2016 ◽  
Vol 18 (9) ◽  
pp. 525-531 ◽  
Author(s):  
Efrat Kochba ◽  
Yotam Levin ◽  
Itamar Raz ◽  
Avivit Cahn
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Pharmacokinetics ◽  
Intradermal Delivery

scholarly journals Evaluation of the Association Metformin:Plantago ovataHusk in Diabetic Rabbits

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Raquel Díez-Láiz ◽  
Juan J. García-Vieitez ◽  
M. José Diez-Liébana ◽  
Matilde Sierra-Vega ◽  
Ana M. Sahagún-Prieto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Experimental Study ◽  
The Other ◽  
Fiber Intake ◽  
Plantago Ovata ◽  
Insulin Pharmacokinetics ◽  
Interindividual Variations ◽  
Diabetic Rabbits ◽  
Oral Hypoglycemic Drugs

In this experimental study we have investigated whether the inclusion of the dietary fiberPlantago ovatahusk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use ofPlantago ovatahusk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented withPlantago ovatahusk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences inCmaxandtmaxin relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase inCmax, AUC, andtmaxin animals fed with fiber. We conclude thatPlantago ovatahusk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.

Intramuscular injection of insulin lispro or soluble human insulin: pharmacokinetics and glucodynamics in Type 2 diabetes

2001 ◽  
Vol 18 (7) ◽  
pp. 562-566 ◽  
Author(s):  
Z. Milicevic ◽  
V. Profozic ◽  
J. Wyatt ◽  
S. Ristic ◽  
J. R. Woodworth ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Human Insulin ◽  
Insulin Lispro ◽  
Intramuscular Injection ◽  
Insulin Pharmacokinetics

scholarly journals Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Li-Ming Gan ◽  
Maria Lagerström-Fermér ◽  
Leif G. Carlsson ◽  
Cecilia Arfvidsson ◽  
Ann-Charlotte Egnell ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Intradermal Delivery

1045: Pioglitazone Ameliorates Penile Corpora Veno-Occlusive Dysfunction (CVOD) in a Rat Model of Type 2 Diabetes

2005 ◽  
Vol 173 (4S) ◽  
pp. 283-284
Author(s):  
Istvan Kovanecz ◽  
Monica G. Ferrini ◽  
Hugo H. Davila ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Type 2 Diabetes ◽  
Rat Model

Youths With Type 2 Diabetes May Face Triple the CV Risk

2008 ◽  
Vol 42 (10) ◽  
pp. 1-4
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Type 2 Diabetes

Should insulin therapy be started earlier in type 2 diabetes?

2008 ◽  
Vol 41 (10) ◽  
pp. 8
Author(s):  
MARTIN J. ABRAHAMSON ◽  
BARRY J. GOLDSTEIN
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy
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